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111.
Verbal–spatial IQ discrepancies impact brain activation associated with the resolution of cognitive conflict in children and adolescents
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Amy E. Margolis Katie S. Davis Lisa S. Pao Amy Lewis Xiao Yang Gregory Tau Guihu Zhao Zhishun Wang Rachel Marsh 《Developmental science》2018,21(2)
Verbal–spatial discrepancies are common in healthy individuals and in those with neurodevelopmental disorders associated with cognitive control deficits including: Autism Spectrum Disorder, Non‐Verbal Learning Disability, Fragile X, 22q11 deletion, and Turner Syndrome. Previous data from healthy individuals suggest that the magnitude of the difference between verbal IQ (VIQ) and performance IQ (PIQ) scores (the VIQ>PIQ discrepancy) is associated with reduced thickness in frontal and parietal cortices (inferior frontal, anterior cingulate, inferior parietal lobule, and supramarginal gyrus) that support cognitive control. Unknown is whether the VIQ>PIQ discrepancy is associated with functional deficits in these areas in healthy or ill children and adolescents. We assessed the effects of the VIQ>PIQ discrepancy on fMRI BOLD response during the resolution of cognitive conflict in 55 healthy children and adolescents during performance of a Simon Spatial Incompatibility task. As the magnitude of the VIQ>PIQ discrepancy increased, activation of fronto‐striatal, limbic, and temporal regions decreased during conflict resolution (p < .05, corrected). In exploratory analyses, the VIQ>PIQ discrepancy was associated with reduced functional connectivity from right inferior frontal gyrus to right thalamus and increased functional connectivity to right supramarginal gyrus (ps < .03, uncorrected). The VIQ>PIQ discrepancy may be an important aspect of an individual's cognitive profile and likely contributes to, or is associated with, deficient cognitive control processes characteristic of many childhood disorders. 相似文献
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肺损伤是体外循环心内直视手术的主要并发症之一.肺损伤的机制十分复杂,主要是全身炎性反应和缺血/再灌注损伤所致.肺保护的方法多种多样,其目的是降低全身炎性反应,减轻或避免缺血/再灌注损伤.本文探讨体外循环肺损伤的机制和保护进展. 相似文献
114.
宫腔镜技术是现代妇科微创技术,宫腔镜技术的产生和发展是技术目的和技术手段矛盾发展的结果,宫腔镜技术的具体应用过程体现了马克思主义哲学原理的作用。以马克思主义哲学为指导,可使我们在对待宫腔镜应用中的具体问题时,高瞻远瞩,安全、有效地对患者实施诊治,同时,提高自己的综合素质。 相似文献
115.
在中华民族文化出现复兴曙光之际,我们在当代文化建设中一定要努力弘扬中华文化。中华文化对世界的独特贡献就在于它崇尚道德的精神,这是中华文化的真正"国粹"。当前文化建设的核心是重新反思我们近百年来受到的西方价值观的影响,着力弘扬中华文化的群体和他人价值导向、义以为上的道义追求、义务为本的责任意识、等差礼让的人际伦理、人心自律的主体精神,只有重新弘扬中华文化的这些核心价值观,才会为民族唤回灵魂,才会为国家发展提供强大的动力和凝聚力,才会为社会提供强有力的粘合剂和调和液,真正重塑起我们的民族精神和国家精神。 相似文献
116.
Wang YJ Lu J Wu DM Zheng ZH Zheng YL Wang XH Ruan J Sun X Shan Q Zhang ZF 《Neurobiology of learning and memory》2011,96(2):156-165
Evidence indicates that systemic administration of lipopolysaccharide (LPS) induces brain inflammation, ultimately resulting in cognitive deficits. Ursolic acid (UA), a plant-derived pentacyclic triterpenoid, is well known to possess multiple biological functions, including antioxidant, anti-tumor and anti-inflammatory activities. In the present study, we assessed the protective effect of UA against the LPS-induced cognitive deficits in mice. We found that UA significantly improved cognitive deficits of LPS-treated mice in open field, step-through passive avoidance and Morris water maze tasks. One potential mechanism of this action was attributed to the decreased production of pro-inflammatory markers including COX-2, iNOS, TNF-α, IL-1β, IL-2 and IL-6 in LPS-treated mouse brain. Mechanistically, UA markedly inhibited LPS-induced IκBα phosphorylation and degradation, NF-κB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. Taken together, these results suggest that UA may be useful for mitigating inflammation-associated brain disorders by inhibiting pro-inflammatory factors production, at least in part, through blocking the p38/NF-κB signaling pathways. 相似文献
117.
This study examined the concordance between parental and youth's perceptions regarding open communication in their families and its association with youth's psychosocial adjustment. The relative importance of parental and adolescents' perceptions of open family communication in relation to youth's psychosocial adjustment was also investigated. Participants were 336 parent-youth dyads from inner-city low-income communities in an eastern city in the United States. Both parental and youth's perceptions of open communication in the family were categorized into "high" and "low" groups using a median split in scores. Four parent-youth concordance groups (i.e. high-high, high-low, low-high and low-low) were derived based on the combination of the levels of parental and youth's perceptions. Parental and youth's perceptions about open communication were modestly correlated (r = 0.129, p < 0.05). The level of concordance differed by youth gender with male adolescents and their parents being more likely to perceive lower levels of open communication (i.e. "low-low") than females and their parents (32% versus 19%, p < 0.05). In general, youth demonstrated poorer psychosocial adjustment if they perceived a lower level of open communication between them and their parents, independent of the level of their parents' perceptions (e.g. "high" or "low"). The findings suggest an important role of adolescents' own perceptions of the openness of the family communication in relation to adolescent psychosocial adjustment. Developmentally and gender appropriate intervention programs are needed to improve the openness of parent-adolescent communication, to help both parents and youth to recognize the significant preventive role of open communication in the family, especially, the socioeconomically disadvantaged families. 相似文献
118.
Jiang Jiang Yu Kou Fang Wang Ying Wu Yan‐Mei Li Yuan Li Yiyin Yang Hui Cao Qiuping Wu Shi‐Jie Jing Bi‐Jing Jiang La‐Mei Shen Ai‐Juan Li Zhongquan Li Wenjun Gao Chi‐Yue Chiu Ying‐Yi Hong Shih‐Chi Hsu Lin Zhang Bao‐Yan Yang Xiao‐Li Yang De‐Lei Zhao Zhimin Zou Qing‐Wang Wei Xia Chen Yu‐Fang Zhao Yi‐Jin Zhou Hong Chen Jianping Feng Xin Wang 《Asian Journal of Social Psychology》2011,14(3):207-216
A scandal can evoke public outrage when it is widely publicized and involves an individual who is perceived to have a high level of cultural representativeness. Two experiments showed that when the scandalous target's moral character was highlighted, emotional responses towards the target were least negative when the scandal was widely circulated and when the target was seen as a representative of his culture. These results suggest that when a cultural symbol is implicated in a widely‐circulated scandal, the negative emotions directed towards the scandalous individual can be alleviated when the public remains confident in his or her commitment to morality. 相似文献
119.
目的:通过问卷调查了解当代大学生的自尊水平及其父母教养方式,并分析两者之间的关系,为父母教育子女提供有效建议。方法:采用分层随机抽样的方法,运用自尊量表(SES)和父母教养方式评价量表(EMBU)对长江大学320名大学生进行调查。结果:1.大学生自尊与情感温暖方式呈显著正相关,与惩罚严厉、过分干涉保护、拒绝否认呈显著负相关,与偏爱被试无显著相关;2.高自尊大学生与低自尊大学生在父亲和母亲的情感温暖、惩罚严厉、拒绝否认上存在显著差异,在父亲的过度保护方面存在显著差异;3.父母教养方式受城乡环境等因素影响。结论:父母应当采取积极的教养方式教育孩子,塑造孩子的自尊。 相似文献
120.
本文尝试从现象学的生活世界观点出发,对黑格尔《精神现象学》之“感性确定性分析”中的动作性词语作一个解释学的解读工作,以便发掘出黑格尔辩证法之中介游戏或者间接同一性机制所以可能发生的动态的源初“地带”。 相似文献