Functional neuroimaging of autistic disorders

Functional neuroimaging methods hold promise for elucidating the neurobiology of autistic disorders, yet they present difficult practical and scientific challenges when applied to these complex and heterogeneous syndromes. Single-state studies of brain metabolism and blood flow thus far have failed to yield consistent findings, but suggest considerable variability in regional patterns of cerebral synaptic activity. Patients with idiopathic autism are less likely to show abnormalities than are patients with comorbid illness or epilepsy. Activation studies have begun to suggest alterations in brain organization for language and cognition. Neurotransmitter studies using positron emission tomography (PET) suggest abnormalities of serotonergic and dopaminergic function. Studies using magnetic resonance spectroscopy (MRS) have begun to document metabolic deficits in the frontal cortex and cerebellum. A single study using magnetoencephalography suggests a high incidence of epileptiform activity in children with autistic regression. Research needs include well-controlled developmental studies, particularly of young subjects and relatively homogeneous subgroups, which balance scientific rigor with ethical constraints. Investigations of the serotonergic and dopaminergic systems, limbic-based memory and emotional systems, and the role of epileptiform activity in autism represent priorities for future research.     

乌托邦是我们时代的哲学范畴

布洛赫被誉为20世纪“乌托邦哲学家”。在他看来,乌托邦是20世纪一个重要的哲学一马克思主义范畴,乌托邦远没有限定在社会领域里,它也存在于艺术中,特别是存在于受表现主义影响的诗人和画家中。具体的乌托邦是一种斗争原理、一支社会力量,它预示政治上的未来远见、新事物的未发现状态。更美好生活的乌托邦不仅照亮未来,也照亮当下。一个马克思主义者不应传播悲观主义。     

A Predicate Logical Extension of a Subintuitionistic Propositional Logic

We develop a predicate logical extension of a subintuitionistic propositional logic. Therefore a Hilbert type calculus and a Kripke type model are given. The propositional logic is formulated to axiomatize the idea of strategic weakening of Kripke's semantic for intuitionistic logic: dropping the semantical condition of heredity or persistence leads to a nonmonotonic model. On the syntactic side this leads to a certain restriction imposed on the deduction theorem. By means of a Henkin argument strong completeness is proved making use of predicate logical principles, which are only classically acceptable.     

Terror of Hope: the Integration of Attachment Theory and Womanist Theology

Hope functions as a potential coping mechanism for individuals who find themselves in stressful or difficult life situations, whether going through a personal grievance or experiencing the pain of systemized oppression. In recent history the study of hope in psychology and theology has grown and become prominent in each field. These forms of hope are often understood in two predominating categories, one which simplifies it to optimism or the other which relegates it to the future. The first understanding of hope, which I refer to as optimistic hope, distills hope into individualistic motivations with goal-setting for the future; individual progression. The second understanding of hope, which I refer to as eschatological hope, pushes hope to the edge of escapism into the next life. However, there is a third type which is influenced by womanist theology—complex hope. By using the work of womanist theologian A. Elaine Brown Crawford, Hope in the Holler and attachment theory, I attempt to show the potential risk and connection between optimistic hope and eschatological hope with insecure attachment types, and complex hope with secure attachment. Then by using the psychological model of self-development, I offer how one might develop mature complex hope in adolescence and adulthood. Lastly, I give a practical application of how one applies this method in their own situation, specifically as a minister or church leader.     

马克思,直路,具体的乌托邦

俄国没有参与资产阶级革命,革命后的俄国出现了绝对的沙皇主义、独裁、恐怖、个人迷信和警察国家.斯大林主义使马克思主义面目全非,损害了马克思本人的形象.马克思恩格斯的无产阶级贫困化理论、危机理论已宣告无效,马克思主义中依然有效的是辩证法,即矛盾学说.资本主义矛盾可精确地理解为总体异化、自我异化.继承天赋人权遗产将决定共产主义的自由面孔.直路的矫形外科是社会主义的最紧迫的任务,而人道的社会主义包含有作为最高人权的直路.马克思主义并非不是乌托邦,而是具体的乌托邦.     

Philosophy's Real-World Consequences for Deaf People: Thoughts on Iconicity, Sign Language and Being Deaf

The body of philosophical knowledge concerning the relations among language, the senses, and deafness, interpreted as a canon of key ideas which have found their way into folk metaphysics, constitutes one of the historically sustained conditions of the oppression of deaf people. Jonathan Rée, with his book I see a voice, makes the point that a philosophical history, grounded in a phenomenological and causal concern with philosophical thought and social life, can offer an archaeology of philosophy's contribution to the social oppression of deaf people.This article offers support for such a project while being critical of Rée's philosophical phenomenology, since it presumes, àpriori, two ideas about deafness and sign language: firstly, that deaf experience is like hearing experience but without hearing; and secondly, that the iconic qualities of sign languages are strictly superficial phenomena. Both presumptions, it is argued here, derive from the same philosophical knowledge which has linked deafness to the sense of hearing and the voice, and in doing so secured an intellectual basis for the oppression of deaf people in social life.Instead it is proposed, using examples of sign language use, that deafness as sensory experience is best understood by reference to the sense of sight; that iconicity is a central creative resource in sign language formation, maintenance and productivity; that Rée's philosophical phenomenology, as a metatheoretical critique of philosophical knowledge, proves unable to selfreflexively uncover (let alone overcome) existing presumptions in philosophy and social life; and that as a consequence that project itself risks perpetuating, within philosophy, key conditions of the oppression of deaf people.     

Collective Action as Individual Choice

We argue that conceptual analyses of collective action should be informed by game-theoretic analyses of collective action. In particular, we argue that Ariel Rubenstein’s so-called ‘Electronic Mail Game’ provides a useful model of collective action, and of the formation of collective intentions.     

The influence of induced mood on the inhibition of emotional information

The ability to inhibit affective information plays a major role in efficient cognitive processing. In this study the effect of mood induction on inhibitory processing of emotional material was investigated. In Experiment 1, performance on a negative affective priming task (NAP) following negative and positive mood induction (MIP) was compared to a neutral mood condition. Results revealed that, as compared with the neutral mood condition, inhibitory function for affective material was unaffected by negative MIP. However, after the positive MIP, inhibitory processes were significantly impaired. In Experiment 2, we replicated and extended the findings on positive affect and inhibition. The data concerning positive mood fit with the general findings that positive mood often leads to a “loose, flexible” processing mode. The null-finding concerning negative mood and inhibition is discussed in the light of research on inhibition in depression.     

Responses to Conflict and Cooperation in Adolescents with Anxiety and Mood Disorders

This study examined patterns of behavioral and emotional responses to conflict and cooperation in adolescents with anxiety/mood disorders and healthy peers. We compared performance on and emotional responses to the Prisoner’s Dilemma (PD) game, an economic exchange task involving conflict and cooperation, between adolescents with anxiety/depressive disorders (A/D) (N=21) and healthy comparisons (n = 29). Participants were deceived to believe their co-player (a pre-programmed computer algorithm) was another study participant. A/D adolescents differed significantly from comparisons in patterns of play and emotional response to the game. Specifically, A/D participants responded more cooperatively to cooperative overtures from their co-players; A/D girls also reported more anger toward co-players than did comparison girls. Our findings indicate that A/D adolescents, particularly females, respond distinctively to stressful social interchanges. These findings offer a first step toward elucidating the mechanisms underlying social impairment in youth with internalizing disorders. This research was supported by the Intramural Research Program of the NIH, NIMH.