Genetic Gating of Human Fear Learning and Extinction: Possible Implications for Gene-Environment Interaction in Anxiety Disorder

ABSTRACT— Pavlovian fear conditioning is a widely used model of the acquisition and extinction of fear. Neural findings suggest that the amygdala is the core structure for fear acquisition, whereas prefrontal cortical areas are given pivotal roles in fear extinction. Forty-eight volunteers participated in a fear-conditioning experiment, which used fear potentiation of the startle reflex as the primary measure to investigate the effect of two genetic polymorphisms (5-HTTLPR and COMTval158met) on conditioning and extinction of fear. The 5-HTTLPR polymorphism, located in the serotonin transporter gene, is associated with amygdala reactivity and neuroticism, whereas the COMTval158met polymorphism, which is located in the gene coding for catechol-O-methyltransferase (COMT), a dopamine-degrading enzyme, affects prefrontal executive functions. Our results show that only carriers of the 5-HTTLPR s allele exhibited conditioned startle potentiation, whereas carriers of the COMT met/met genotype failed to extinguish conditioned fear. These results may have interesting implications for understanding gene-environment interactions in the development and treatment of anxiety disorders.     

Perceptions of the Woman Who Breastfeeds: The Role of Erotophobia,Sexism, and Attitudinal Variables

Perceptions of breastfeeding women were studied in a sample of 201 predominately European American college students. Both men and women had very positive perceptions of breastfeeding women as compared to bottlefeeding women. As predicted, erotophobic women and men had less favorable impressions of the breastfeeding woman than did erotophilic individuals. Men, but not women, who scored high on Glick and Fiske's Benevolent Sexism or Hostile Sexism scales (Glick & Fiske, 1996) had more favorable impressions of the breastfeeding woman than did those with low scores. As predicted, this effect was larger for Benevolent Sexism than for Hostile Sexism. No relationships were found between impressions of breastfeeding women and the Hostility Toward Women Scale (Lonsway & Fitzgerald, 1995) or the Trait Guilt and Moral Standards scales (Jones, Schratter, & Kugler, 2000). The results supported hypotheses that sexualization of the breast, discomfort with sexual stimuli, and sexist attitudes are related to perceptions of the breastfeeding woman.     

Adjustment and acceptance beliefs in achievement settings: Implications for student wellbeing

Social Psychology of Education - Research suggests that when dealing with personal setbacks, secondary control (SC) adjustment and acceptance beliefs can foster psychological wellbeing. However,...