Some fear-potentiating effects of fluprazine hydrochloride in mice

The fear-potentiating effects of fluprazine hydrochloride were explored in a series of five experiments. The drug was found to strongly inhibit entry into a novel open field, exploration of a complex maze, or approach to a novel object placed in the animal's home cage. Time sampling techniques were used to assess drug effects on frequencies of immobility, activity, and grooming and rearing responses prior to and for 70 min after footshock. There were no group differences during the 10 min immediately following shock but the groups diverged steadily in immobility, activity, and grooming for the remainder of the observations. Post-shock activity and grooming responses increased steadily towards baseline values among control mice but remained at low levels or declined among drug-treated mice. Immobility responses declined steadily among control mice but increased substantially among the fluprazine-treated mice throughout post-shock observations. Pairs of male mice treated with fluprazine were also found to maintain greater intermouse distances in a novel linear runway than pairs of undrugged adult males, juvenile males, or male-female pairs. It is suggested that fluprazine hydrochloride both potentiates fear and alters its time course in addition to interfering in some way with normal olfactory processes.     

Are the Medical Humanities for Sale? Lessons from a Historical Debate

In November of 1959, William Bean published in the Archives of Internal Medicine a scathing review of Félix Martí-Ibañez’s Centaur: Essays on the History of Medical Ideas. Martí-Ibañez and Bean were two of the leading exponents of the importance of medical humanism during a formative period from the 1950s through the 1970s. But the two physicians differed fundamentally in their views of the ideal relationships among the pharmaceutical industry, the medical profession, and the medical humanities. We situate Bean’s review within its historical context, shedding light on the history and diverging uses of the medical humanities.     

Parent–Child Synchrony in Children with Oppositional Defiant Disorder: Associations with Treatment Outcomes

Oppositional defiant disorder (ODD), characterized by angry/irritable mood, and argumentative/defiant behavior, is associated with significant negative outcomes in childhood and beyond. Researchers posit that these behaviors arise from poor parenting and/or an incompatibility between characteristics of the child and the child’s parents, resulting in strained interaction styles. The present study examines parent–child synchrony, the inverse of parent–child incompatibility as a predictor of children’s emotional lability, aggression, and overall functioning following psychosocial treatment. Participants were 75 treatment-seeking families with children diagnosed with ODD (46 boys). Families received one of two empirically supported treatments for ODD (Parent Management Training or Collaborative and Proactive Solutions). Findings indicated that pre-treatment parent–child synchrony was associated with decreased emotional lability and aggression following both treatments, as well as improvement in overall functioning, irrespective of treatment condition. These results reflect the importance of parent–child relations at the onset of treatment in predicting response to treatment and suggest potential treatment targets within parent–child relationships.     

Examining Children’s Problem Behaviors and Mothers’ Dating for Mothers’ Depressive Symptoms Following Divorce

Journal of Child and Family Studies - Although divorce is typically stressful for mothers, the formation of post-divorce dating relationships can help to ease this stress. Unfortunately, research...     

Opening minds by supporting needs: do autonomy and competence support facilitate mindfulness and academic performance?

Social Psychology of Education - In a pair of studies, the present research examined mindfulness as a mediator through which perceived support for the basic psychological needs of autonomy and...     

Processes and outcomes in prevention-focused time-limited groups for girls

Processes and outcomes in 8-week prevention-focused, school-based groups for preadolescent girls were assessed in a naturalistic study. Specifically, whether such groups would facilitate their social-emotional development and whether affiliative processes in the groups were related to outcome were explored. In addition to expecting the groups to be effective, it was hypothesized that affiliative processes would be directly related to outcome and, more particularly, that increased positive affiliative feelings from the group toward the individual would be more predictive of positive treatment outcome than increased positive feelings from the individual toward the group. While findings did not support these hypotheses linking process to outcome, ancillary analyses revealed that different patterns of affiliation over time (i.e., U-shape pattern versus inverted U-shape pattern) distinguished the high- versus low-outcome participants, respectively.