BEHAVIOUR OF RATS UNDER THE INFLUENCE OF ETHYL ALCOHOL IN AN OPEN-FIELD SITUATION

In a standardized open-field test, ambulation, defecation, time of non-locomotor activity, time spent motionless, preening, and rearing were recorded. Inter-observer differences were small. Test repetition caused significant behavioural changes. Different rats were used for each of five doses of alcohol (0.5–2 mg/g). The lowest dose (0.75 mg/g) affecting behaviour significantly increased time motionless, decreased non-locomotor activity, and depressed preening. Ambulation was the last sensitive measure of behaviour. The results suggest that arousal mechanisms are particularly sensitive to alcohol. The procedure seems useful for studies of effects of small doses of alcohol.     

Science as a Vocation in the Era of Big Data: the Philosophy of Science behind Big Data and humanity’s Continued Part in Science

We now live in the era of big data, and according to its proponents, big data is poised to change science as we know it. Claims of having no theory and no ideology are made, and there is an assumption that the results of big data are trustworthy because it is considered free from human judgement, which is often considered inextricably linked with human error. These two claims lead to the idea that big data is the source of better scientific knowledge, through more objectivity, more data, and better analysis. In this paper I analyse the philosophy of science behind big data and make the claim that the death of many traditional sciences, and the human scientist, is much exaggerated. The philosophy of science of big data means that there are certain things big data does very well, and some things that it cannot do. I argue that humans will still be needed for mediating and creating theory, and for providing the legitimacy and values science needs as a normative social enterprise.     

Multiple layers of information processing in deductive reasoning: combining dual strategy and dual-source approaches to reasoning

The idea that inferential performance cannot be analyzed within a single model has been suggested within two theoretical contexts. The dual strategy model suggests that people reason using different approaches to processing statistical information. The dual-source model suggests that people reason probabilistically using both statistical information and some intuition about logical form. Each model suggests that people have different approaches to processing information while making inferences. The following studies examined whether these different forms of information processing were equally present during reasoning. Participants were given a series of problems designed to distinguish counterexample from statistical reasoners. They were then given a series of MP or AC inferences for which identical statistical information was provided. Results show that MP inferences were considered to be deductively valid more often than equivalent AC inferences. The effect of logical form was independent of reasoning strategy, and of relatively equivalent size for both counterexample and statistical reasoners. The second study examined explicitly probabilistic inferences, and showed smaller effects of logical form and of reasoning strategy, although with a complex set of interactions. These results show that understanding the way that people use information when making inferences requires a multidimensional approach.     

The legal basis for the Danish committee on scientific dishonesty

The author, a High Court Judge, has chaired the Danish Committee on Scientific Dishonesty (DCSD) since its establishment in 1992. The Committee has worked in the health sector, but from 1999 the scope has been broadened to cover all fields of science. The article describes how the work is organised and the experiences gained. It is stressed, that the difficulty in connection with scientific dishonesty is, first and foremost, to organise a system suitable for investigating cases effectively, professionally, and with proper respect to the fundamental legal rights of the parties involved. The Committee has also spent much effort in determining what can be termed scientific dishonesty and what falls outside this category but which may, nevertheless, be characterised as breaching of good scientific practice. It is emphasised that these rules are not arbitrarily established by the Committee, but formulated in accordance with norms general accepted by opinion leaders in the scientific community. An carlier version of this paper was presented at a symposium, Scientific Misconduct. An International Perspective, organised by The Medical University of Warsaw, 16 November, 1998. The article is based on more comprehensive articles by the same author in DCSD’s Annual Reports for 1993 and 1995.     

Analysis of the decision-making process leading to appendectomy: a grounded theory study

The aim was to develop a theoretical understanding of the decision-making process leading to appendectomy. A qualitative interview study was performed in the grounded theory tradition using the constant comparative method to analyze data. The study setting was one county hospital and two local hospitals in Sweden, where 11 surgeons and 15 surgical nurses were interviewed. A model was developed which suggests that surgeons' decision making regarding appendectomy is formed by the interplay between their medical assessment of the patient's condition and a set of contextual characteristics. The latter consist of three interacting factors: (1) organizational conditions, (2) the professional actors' individual characteristics and interaction, and (3) the personal characteristics of the patient and his or her family or relatives. In case the outcome of medical assessment is ambiguous, the risk evaluation and final decision will be influenced by an interaction of the contextual characteristics. It was concluded that, compared to existing, rational models of decision making, the model presented identified potentially important contextual characteristics and an outline on when they come into play.     

The cognitive substrate of subjective probability

The prominent cognitive theories of probability judgment were primarily developed to explain cognitive biases rather than to account for the cognitive processes in probability judgment. In this article the authors compare 3 major theories of the processes and representations in probability judgment: the representativeness heuristic, implemented as prototype similarity, relative likelihood, or evidential support accumulation (ESAM; D. J. Koehler, C. M. White, & R. Grondin, 2003); cue-based relative frequency; and exemplar memory, implemented by probabilities from exemplars (PROBEX; P. Juslin & M. Persson, 2002). Three experiments with different task structures consistently demonstrate that exemplar memory is the best account of the data whereas the results are inconsistent with extant formulations of the representativeness heuristic and cue-based relative frequency.     

Using artificial life to teach evolutionary biology

This paper presents a pilot study on the use of artificial life software in an educational setting. Two groups of high school students received a standard lesson in evolutionary biology followed by a software session. The experimental group used the suite of artificial life software presented in this paper; the control group used a commercial multimedia hypertext. At the end of the software session both groups were asked to fill in a simple multiple-choice questionnaire testing the students knowledge of various aspects of evolutionary biology. The results show that the group using the artificial life software performed significantly better than the control group. We argue that the experimental group may learn more effectively because the artificial life makes it possible for students to perform experiments, a possibility not available to the control group.

Sex differences in episodic memory: minimal influence of estradiol

Sex differences exist for several cognitive tasks and estrogen has been suggested to influence these differences. Eighteen men and 18 women were matched on age and estradiol level. Potential sex differences were assessed in episodic memory, semantic memory, verbal fluency, problem solving, and visuospatial ability. Significant sex differences, favoring women, were found for tasks assessing episodic memory. Correlations between estradiol level and cognitive performance were significant for face recognition in females. Since sex differences remained in verbal episodic memory tasks and face recognition despite matched levels of estradiol, circulating estradiol does not appear to be of paramount consequence for observed sex differences in episodic memory.