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121.
Veen G Giltay EJ van Vliet IM Derijk RH Klaassens ER van Pelt J Zitman FG 《Stress (Amsterdam, Netherlands)》2011,14(2):128-135
Cortisol affects the acute-phase response, but it is unknown whether C-reactive protein (CRP), an acute-phase reactant, also affects hypothalamus?pituitary?adrenal axis activity. In the present study, associations were explored between CRP haplotypes with plasma CRP concentrations and basal salivary cortisol level. We included 266 physically healthy Caucasian subjects (103 females and 163 males) aged between 18 and 65 years of whom 94 had a psychiatric disorder in a genetic association study. Six tag single-nucleotide polymorphisms capturing the common genetic variation of the CRP gene were genotyped (i.e. rs2808628, rs2808630, rs1205, rs1800947, rs1417938, and rs3091244) to yield common CRP haplotypes. Plasma CRP concentrations, the salivary cortisol awakening response (CAR) (0, 30, 45, and 60?min after awakening), and the diurnal cortisol decline (11:00, 15:00, 19:00, and 23:00 h) were assessed for 2 days. rs2808628, rs1205, rs1417938, and rs3091244 showed expected associations not only with CRP concentrations, but also with salivary cortisol levels during the CAR. Five well-characterized CRP haplotypes were arranged in ascending order according to increasing CRP levels. There was an inverse linear association between CRP haplotypes and cortisol levels during the CAR, but no association with the diurnal cortisol decline. Hence, genetic variants in the CRP gene that are associated with lifetime plasma CRP levels were also associated with salivary cortisol levels after awakening, in basal, non-inflammatory conditions. 相似文献
122.
Nonclinical use of online social networking sites: new and old challenges to medical professionalism
The AMA Council on Ethical and Judicial Affairs (CEJA) has written a position paper on how social medical use challenges medical professionalism. The report offers persuasive ethical and practical guidelines for nonclinical internet use, specifically for social networking. This commentary provides a framework from which to apply these guidelines, but adds that there may be important situations in which physicians are not able to act in accordance. The guidelines call for professional reporting of questionable online portrayals or behaviors, but this commentary argues that this may be not only cumbersome to implement, but may violate aspects of constitutional rights. While online social networking may in many ways be a new application of old challenges, there may be other aspects that require novel approaches to medical professionalism. 相似文献
123.
Plaisted, O'Riordan and colleagues (Plaisted, O'Riordan & Baron-Cohen, 1998; O'Riordan, 2004) showed that school-age children and adults with Autism Spectrum Disorder (ASD) are faster at finding targets in certain types of visual search tasks than typical controls. Currently though, there is very little known about the visual search skills of very young children (1-3-year-olds) - either typically developing or with ASD. We used an eye-tracker to measure looking behavior, providing fine-grained measures of visual search in 2.5-year-old toddlers with and without ASD (this representing the age by which many children may first receive a diagnosis of ASD). Importantly, our paradigm required no verbal instructions or feedback, making the task appropriate for toddlers who are pre- or nonverbal. We found that toddlers with ASD were more successful at finding the target than typically developing, age-matched controls. Further, our paradigm allowed us to estimate the number of items scrutinized per trial, revealing that for large set size conjunctive search, toddlers with ASD scrutinized as many as twice the number of items as typically developing toddlers, in the same amount of time. 相似文献
124.
Recognition memory was examined for visual affective stimuli using behavioral and event-related brain potential (ERP) measures.
Images from the International Affective Picture System (IAPS) that varied systematically in arousal level (low, high) and
valence direction (unpleasant, pleasant) were first viewed passively. Then, during a response phase, the original images were
intermixed with an equal number of new images and presented, and participants were instructed to press a button to indicate
whether each stimulus picture was previously viewed (target) or new (foil). Participants were more sensitive to unpleasant-
than to pleasant-valence stimuli and were biased to respond to high-arousal unpleasant stimuli as targets, whether the stimuli
were previously viewed or new. Response times (RTs) to target stimuli were systematically affected by valence, whereas RTs
to foil stimuli were influenced by arousal level. ERP component amplitudes were generally larger for high than for low arousal
levels. The P300 (late positive component) amplitude was largest for high-arousal unpleasant target images. These and other
amplitude effects suggest that high-arousal unpleasant stimuli engage a privileged memory-processing route during stimulus
processing. Theoretical relationships between affective and memory processes are discussed. 相似文献
125.
Self‐ratings of personality predict academic success above general intelligence. The present study replicated these findings and investigated the increment of other‐ratings or intentionally distorted self‐ratings. Participants (N = 145) had to compile a personality questionnaire twice. First they were given neutral instructions. The second time they were asked to imagine a specific applicant setting. Furthermore, two peers rated each participant. Additionally, verbal, numerical and figural reasoning scores were obtained. Grades on a statistics exam obtained 2 months later served as the criterion. Results replicated prior findings and showed incremental validity for self‐ and other‐rated personality, which was stable after controlling for intelligence. Faking had no impact on the domain‐score level, but results on the facet‐score level were less encouraging. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
126.
Teije A. Koopmans Johanna M. Geleijnse Frans G. Zitman Erik J. Giltay 《Journal of Happiness Studies》2010,11(1):113-124
Positive psychological characteristics may be beneficial for physical health. However, prospective data on the effects of happiness on survival is scarce. In a population-based cohort study, the Arnhem Elderly Study, happiness was measured by two items, being: “I have many moments of happiness” and “I often laugh happily”. In Cox proportional hazard models, happiness was analyzed as a predictor of 15 year all-cause mortality for 861 (85%) of 1,012 elderly subjects aged 65–85 years. Results showed that happiness was inversely associated with mortality (age- and sex-adjusted hazard ratio of 0.78 for happy subjects versus unhappy subjects; 95% confidence interval 0.64–0.95, P = 0.01 for trend), but that this relationship was no longer statistically significant after adjustment for physical activity and prevalent morbidity. Thus, happiness predicts for lower mortality, which may partly be mediated by more physical activity and lower morbidity. 相似文献
127.
Pollatsek A Juhasz BJ Reichle ED Machacek D Rayner K 《Journal of experimental psychology. Human perception and performance》2008,34(3):726-750
Three experiments examined the effects in sentence reading of varying the frequency and length of an adjective on (a) fixations on the adjective and (b) fixations on the following noun. The gaze duration on the adjective was longer for low frequency than for high frequency adjectives and longer for long adjectives than for short adjectives. This contrasted with the spillover effects: Gaze durations on the noun were longer when adjectives were low frequency but were actually shorter when the adjectives were long. The latter effect, which seems anomalous, can be explained by three mechanisms: (a) Fixations on the noun are less optimal after short adjectives because of less optimal targeting; (b) shorter adjectives are more difficult to process because they have more neighbors; and (c) prior fixations before skips are less advantageous places to extract parafoveal information. The viability of these hypotheses as explanations of this reverse length effect on the noun was examined in simulations using an updated version of the E-Z Reader model (A. Pollatsek, K. Reichle, & E. D. Rayner, 2006c; E. D. Reichle, A. Pollatsek, D. L. Fisher, & K. Rayner, 1998). 相似文献
128.
Examples of visual motion have become more and more abstract over the years, leading up to 'third-order' stimuli where direction is actually determined by the observer through top - down attention. But how far can this be pushed--are there motion stimuli that are yet more arbitrary and abstract? Actually, there is a broad class of 'conceptual motion' stimuli--things like a moving grating of faces, or a shifting pattern of words--that are perfect analogs to traditional 'perceptual motion' stimuli, solvable by the same motion computation and for which observers can readily make direction-of-motion judgments. Interestingly though, these do not produce a sensation of motion (among other automatic consequences of motion detection). Here we compare a luminance-based perceptual motion stimulus to a semantic-based conceptual motion stimulus to contrast the psychophysical hallmarks of these motion categories. 相似文献
129.
Rhee SH Willcutt EG Hartman CA Pennington BF DeFries JC 《Journal of abnormal child psychology》2008,36(1):29-40
There is significant comorbidity between attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD). The conclusions
of studies that examined the causes of comorbidity between ADHD and CD conflict, with some researchers finding support for
the three independent disorders model and others finding support for the correlated risk factors model. We tested these models
and eleven alternative hypotheses using the same analytical approach. The participants were 110 monozygotic twin pairs and
181 dizygotic twin pairs recruited from the Colorado Learning Disabilities Research Center Twin Study. The three independent
disorders model did not fit the data, whereas the correlated risk factors model fit the data well. Several other comorbidity
models fit the data as well as or better than the correlated risk factors model. The results suggest that correlated risk
factors are a better explanation for the comorbidity between ADHD and CD than a third, independent ADHD+CD subtype. 相似文献
130.
We review the history and current status of the person–situation debate. We propose that the person–situation debate (1) is over and (2) that it ended in a ‘Hegelian’ synthesis. Specifically, we propose the following synthesis resolution: There are multiple types of consistency; behavior is consistent for some of those types and not for others; and personality and traits exist in the forms that produce the consistent behaviors. Incorporating both personality processes and trait structures in research will move personality research forward. In this article, we summarize the advances that the two perspectives have generated by working in opposition; we explain why both sides will suffer from continuing to work independently; and we anticipate several future directions that synthesis‐informed personality research can and should take. 相似文献