A role for Synapsin in associative learning: the Drosophila larva as a study case

Synapsins are evolutionarily conserved, highly abundant vesicular phosphoproteins in presynaptic terminals. They are thought to regulate the recruitment of synaptic vesicles from the reserve pool to the readily-releasable pool, in particular when vesicle release is to be maintained at high spiking rates. As regulation of transmitter release is a prerequisite for synaptic plasticity, we use the fruit fly Drosophila to ask whether Synapsin has a role in behavioral plasticity as well; in fruit flies, Synapsin is encoded by a single gene (syn). We tackled this question for associative olfactory learning in larval Drosophila by using the deletion mutant syn^97CS, which had been backcrossed to the Canton-S wild-type strain (CS) for 13 generations. We provide a molecular account of the genomic status of syn^97CS by PCR and show the absence of gene product on Western blots and nerve-muscle preparations. We found that olfactory associative learning in syn^97CS larvae is reduced to ~50% of wild-type CS levels; however, responsiveness to the to-be-associated stimuli and motor performance in untrained animals are normal. In addition, we introduce two novel behavioral control procedures to test stimulus responsiveness and motor performance after “sham training.” Wild-type CS and syn^97CS perform indistinguishably also in these tests. Thus, larval Drosophila can be used as a case study for a role of Synapsin in associative learning.     

Social influence: A discussion and integration of recent models into a general group situation theory

Three models of social influence are presented and their principles discussed in depth: social impact theory, the social influence model and group situation theory. A detailed model of social impact is developed and combined with the group situation theory. The integration of these concepts is utilized to reanalyse several classical studies in social facilitation, social inhibition, crowding, social loafing, and helping in an emergency. Finally, in order to emphasize their differences, the three models are used to explain the Asch studies. The combination of a detailed version of social impact theory with group situation theory results in a middle range theory of group behaviour.     

Psychosocial factors in heart surgery: presurgical vulnerability and postsurgical recovery

OBJECTIVE: Distress and low perceived social support were examined as indicators of psychosocial vulnerability in patients about to undergo heart surgery. Design: A total of 550 study patients underwent heart surgeries, including bypass grafting and valve procedures. Psychosocial interviews were conducted about five days before surgery, and biomedical data were obtained from hospital records. MAIN OUTCOME MEASURES: Sociodemographic, personality, religious, and biomedical factors were evaluated as predictors of psychosocial vulnerability, and all five sets of variables were evaluated as contributors to hospital length of stay (LOS). RESULTS: Patients scoring higher on one or more indicator of presurgical psychosocial vulnerability were younger, more likely to be female, less likely to be married, less well educated, lower in dispositional optimism, higher in trait anger, and lower in religiousness. Older age, depression, low support, and low trait anger each showed an independent, prospective association with greater LOS, and several other predictors had prospective relationships with LOS that were statistically mediated by depression or perceived support. CONCLUSION: Evidence that multiple psychosocial factors may influence adaptation to heart surgery has implications for understanding and ameliorating presurgical distress and for improving postsurgical recovery.     

Credit use: psychological perspectives on a multifaceted phenomenon

Consumer borrowing is a highly topical and multifaceted phenomenon as well as a popular subject for study. We focus on consumer credit use and review the existing literature. To categorize what is known we identify four main psychological perspectives on the phenomenon: credit use as (1) a reflection of the situation, (2) a reflection of the person, (3) a cognitive process, and (4) a social process. On top of these perspectives we view credit use as a process that entails three distinct phases: (1) processes before credit acquisition, (2) processes at credit acquisition, and (3) processes after credit acquisition. We review the international literature along a two-tier structure that aligns the psychological perspectives with a process view of credit. This structure allows us to identify systematic concentrations as well as gaps in the existing research. We consolidate what is known within each perspective and identify what seems to be most urgently missing. Some of the most important gaps relate to research studying credit acquisition from the perspective of credit use as a reflection of the person or as a social process. In particular, research on credit use as a reflection of the person appears to focus exclusively on the first stage of the credit process. We conclude with a discussion that reaches across perspectives and identifies overarching gaps, trends, and open questions. We highlight a series of implicit linkages between perspectives and the geographical regions in which studies related to the perspectives were conducted. Beyond diagnosing a geographical imbalance of research, we argue for future research that systematically addresses interrelations between perspectives. We conclude with a set of global implications and research recommendations.     

A computer program for testing and analyzing random generation behavior in normal and clinical samples: The Mittenecker Pointing Test

Random sequence generation tests have proved to be a useful diagnostic tool for the identification of clinically relevant impairments of executive functions and for the study of cognitive functioning in healthy individuals. The most prevalent variety, random number generation, involves several limitations, however. In the original Mittenecker Pointing Test (MPT; Mittenecker, 1958), subjects were instructed to point successively and as randomly as possible at nine unlabeled circles irregularly arranged on a cardboard. With the computer program presented here, Mittenecker’s classical test has been transferred to a contemporary format. The MPT can be applied using a standard PC keyboard and computes a series of sophisticated measures of deviations from randomness on the basis of information theory analysis. Because of its easy and well-controlled administration and reduced demands on memory and attention, the automatized MPT offers a wide range of application possibilities in normal but also in severely impaired clinical samples.     

Evidence for a cognitive control network for goal-directed attention in simple sustained attention

The deterioration of performance over time is characteristic for sustained attention tasks. This so-called “performance decrement” is measured by the increase of reaction time (RT) over time. Some behavioural and neurobiological mechanisms of this phenomenon are not yet fully understood. Behaviourally, we examined the increase of RT over time and the inter-individual differences of this performance decrement. On the neurophysiological level, we investigated the task-relevant brain areas where neural activity was modulated by RT and searched for brain areas involved in good performance (i.e. participants with no or moderate performance decrement) as compared to poor performance (i.e. participants with a steep performance decrement). For this purpose, 20 healthy, young subjects performed a carefully designed task for simple sustained attention, namely a low-demanding version of the Rapid Visual Information Processing task. We employed a rapid event-related functional magnetic resonance imaging (fMRI) design. The behavioural results showed a significant increase of RT over time in the whole group, and also revealed that some participants were not as prone to the performance decrement as others. The latter was statistically significant comparing good versus poor performers. Moreover, high BOLD-responses were linked to longer RTs in a task-relevant bilateral fronto-cingulate-insular-parietal network. Among these regions, good performance was associated with significantly higher RT-BOLD correlations in the pre-supplementary motor area (pre-SMA). We concluded that the task-relevant bilateral fronto-cingulate-insular-parietal network was a cognitive control network responsible for goal-directed attention. The pre-SMA in particular might be associated with the performance decrement insofar that good performers could sustain activity in this brain region in order to monitor performance declines and adjust behavioural output.     

Frege,Dedekind, and the Origins of Logicism

This paper has a two-fold objective: to provide a balanced, multi-faceted account of the origins of logicism; to rehabilitate Richard Dedekind as a main logicist. Logicism should be seen as more deeply rooted in the development of modern mathematics than typically assumed, and this becomes evident by reconsidering Dedekind's writings in relation to Frege's. Especially in its Dedekindian and Fregean versions, logicism constitutes the culmination of the rise of ‘pure mathematics’ in the nineteenth century; and this rise brought with it an inter-weaving of methodological and epistemological considerations. The latter aspect illustrates how philosophical concerns can grow out of mathematical practice, as opposed to being imposed on it from outside. It also sheds new light on the legacy and the lasting significance of logicism today.     

Boundaries of Citizenship Behavior: Curvilinearity and Context in the Citizenship and Task Performance Relationship

Resource allocation, attentional capacity, and role theories all suggest that the well‐documented linear relationship between citizenship behavior and task performance may be more complex than previously believed. In a study of 352 incumbents, we develop hypotheses that propose a curvilinear effect of employee citizenship on task performance. We further argue that this nonmonotonic relationship is different across the targets of citizenship performance and is moderated by several factors from the task context. Results support the curvilinear assertion, indicating that the relationship with task performance inflects when citizenship is more frequently performed. These diminishing returns are amplified when the target of citizenship is the organization compared to the individual. Findings further reveal that the task context elements of accountability and autonomy moderate the curvilinear relationship, whereas ambiguity does not. Implications for a reappraisal of the citizenship–task performance relationship are discussed.