Typologies of Alcohol Dependence. From Jellinek to Genetics and Beyond

The goal of typology research is to identify subtypes of alcohol dependent (AD) patients sharing fundamental characteristics and try to match each subtype, with the most precise treatment strategy. This review provides a comprehensive history of the literature on alcohol dependent subtypes starting from the earliest attempt made by Jellinek. The binary models identified most closely with Cloninger and Babor as well as the successively more complex classifications are discussed. Typology classification potentially useful in guiding the treatment of AD patients, especially in the case of the serotonergic medications. Contrasting data suggests that other factors could influence the response to a medication and/or that more complex typologies should be identified. In summary, typology models may assist in the ascertainment criteria for clinical trials performed in behavioral and pharmacotherapeutic interventions. Greater emphasis, however, must be made to more clearly delineate this field of research, while moving toward more standardized typologies.     

EQUIVALENCE CLASS FORMATION IN A TRACE STIMULUS PAIRING TWO‐RESPONSE FORMAT: EFFECTS OF RESPONSE LABELS AND PRIOR PROGRAMMED TRANSITIVITY INDUCTION

Three experiments identified factors that did and did not enhance the formation of two‐node four‐member equivalence classes when training and testing were conducted with trials presented in a trace stimulus pairing two‐response (SP2R) format. All trials contained two separately presented stimuli. Half of the trials, called within‐class trials, contained stimuli from the same class while the other half, called cross class trials, contained stimuli from different classes. On within class trials, making a YES response was correct and making a NO response was wrong. On cross class trials, making a NO response was correct and making a YES response was wrong. In Experiment 1, similar intermediate percentages of participants (about 50%) formed classes, regardless of whether the responses were labeled YES and NO or SAME and DIFF. Response labeling thus did not influence class formation. Regardless of response labels, failures of class formation were primarily due to failure of class‐indicative responding produced by within‐class transitivity probes. In Experiment 2, only 50% of participants formed classes without prior training, as in Experiment 1, but 100% of participants formed equivalence classes after the establishment of a generalized transitivity repertoire by use of a programmed transitivity induction protocol. Experiment 3 examined two components of the programmed transitivity induction protocol and found that the exclusion of AC trials had no effect on the percentage of participants who formed equivalence classes, while presenting the stimulus sets in randomized order interfered with equivalence class formation. A further analysis found that a number of stimulus control topographies differentiated between individuals who did and did not form equivalence classes. In general, then, these experiments demonstrate that equivalence classes can be formed reliably when training and testing are conducted in an SP2R format, supporting the view that equivalence class formation can account for the development of conceptual categories in natural settings.     

ACT in Context: An Exploration of Experiential Acceptance

Experiential acceptance, which involves “having,” or “allowing” private experiences, has recently gained much attention in the cognitive-behavioral literature. Acceptance, however, may be considered a common factor among psychotherapeutic traditions. The purposes of this paper are to examine the historical roots of acceptance and to discuss the forms of and theoretical rationales for which the concept of acceptance has been recently introduced into the cognitive-behavioral literature, with an emphasis on acceptance and commitment therapy (ACT; Hayes, Strosahl, & Wilson, 1999). It is hoped that clarification of the theoretical basis underlying acceptance-based approaches, as well as a comparison of various forms of psychotherapy with regard to their emphasis on acceptance, will promote heightened understanding and stimulate more rigorous exploration of treatment efficacy.     

The dangers of dating the “bad boy” (or girl): When does romantic desire encourage us to take on the negative qualities of potential partners?

People generally strive to maintain positive views of themselves. Even in the face of negative feedback, individuals frequently protect the self-concept from incorporating negative information. Two studies examined a potential exception to that rule: whether and when romantic desire may motivate individuals to spontaneously adopt the negative attributes of a potential partner. Study 1 demonstrated the basic effect such that single individuals spontaneously incorporated negative attributes of a potential romantic partner into their self-concepts, and incorporation was magnified by desire for the partner. Study 2 explored boundary conditions of these effects. Negative attributes were only incorporated if the potential partner expressed self-acceptance about possessing these attributes; when potential partners reported wishing to change the negative attribute, it was not adopted into the self-concept. Attribute extremity also moderated incorporation. The implications of these results for understanding the nuances of motivated self-malleability are discussed.     

Trauma and sex surveys meet minimal risk standards: implications for institutional review boards

Institutional review boards assume that questionnaires asking about "sensitive" topics (e.g., trauma and sex) pose more risk to respondents than seemingly innocuous measures (e.g., cognitive tests). We tested this assumption by asking 504 undergraduates to answer either surveys on trauma and sex or measures of cognitive ability, such as tests of vocabulary and abstract reasoning. Participants rated their positive and negative emotional reactions and the perceived benefits and mental costs of participating; they also compared their study-related distress with the distress arising from normal life stressors. Participants who completed trauma and sex surveys, relative to participants who completed cognitive measures, rated the study as resulting in higher positive affect and as having greater perceived benefits and fewer mental costs. Although participants who completed trauma and sex surveys reported slightly higher levels of negative emotion than did participants who completed cognitive measures, averages were very low for both groups, and outliers were rare. All participants rated each normal life stressor as more distressing than participating in the study. These results suggest that trauma and sex surveys pose minimal risk.     

Myosin II motor activity in the lateral amygdala is required for fear memory consolidation

Learning induces dynamic changes to the actin cytoskeleton that are required to support memory formation. However, the molecular mechanisms that mediate filamentous actin (F-actin) dynamics during learning and memory are poorly understood. Myosin II motors are highly expressed in actin-rich growth structures including dendritic spines, and we have recently shown that these molecular machines mobilize F-actin in response to synaptic stimulation and learning in the hippocampus. In this study, we report that Myosin II motors in the rat lateral amygdala (LA) are essential for fear memory formation. Pretraining infusions of the Myosin II inhibitor, blebbistatin (blebb), disrupted long term memory, while short term memory was unaffected. Interestingly, both post-training and pretesting infusions had no effect on memory formation, indicating that Myosin II motors operate during or shortly after learning to promote memory consolidation. These data support the idea that Myosin II motor-force generation is a general mechanism that supports memory consolidation in the mammalian CNS.     

Evaluation of an Internet-short message service-based intervention for promoting physical activity in Hong Kong Chinese adolescent school children: a pilot study

Evaluation of acceptability and preliminary efficacy of an Internet and short message service (SMS) intervention for promoting physical activity (PA) in Hong Kong Chinese school children. An 8-week quasi-experimental study non-randomly assigned 78 school children (mean age=12.8 years) to (a) an intervention group that received a stage-matched, Internet PA program two times a week and tailored SMS messages daily; or (b) a no-treatment control. Data were collected from September 2008 until June 2009. Acceptability measures included exposure rate and participant's satisfaction. Efficacy measures were changes in stage of motivational readiness (SMR) and self-reported PA level. Intervention participants demonstrated significant pre-post increments in SMR (Z=-2.558, p=0.011) and self-reported PA level [F(1, 76)=4.50, p=0.04]. There was a non-significant trend between groups in both SMR (p=0.24) and PA (p=0.13). Despite the similar ratings of satisfaction between Internet (M=3.12±0.74) and SMS (M=3.12±0.84), participants displayed distinct patterns of exposure with 66% exhibiting a weekly login rate of 0.5 times/person and an average of 3.75 minutes/visit/person. In contrast, 79% of participants read an average of 1.3 SMS/person/week and 47% voluntarily replied to ～3.8 SMS/person. These findings demonstrate the acceptability and preliminary efficacy of an Internet-SMS-based intervention for promoting PA in Hong Kong school children. The divergent exposure rates between the Internet and SMS may be a unique pattern for adolescents in early SMR. Future research should be cognizant of the importance of SMR since it may influence utilization and/or adherence.