Age-related enhancement of a protein synthesis-dependent late phase of LTP induced by low frequency paired-pulse stimulation in hippocampus

Protein synthesis-dependent late phase of LTP (L-LTP) is typically induced by repeated high-frequency stimulation (HFS). This form of L-LTP is reduced in the aged animal and is positively correlated with age-related memory loss. Here we report a novel form of protein synthesis-dependent late phase of LTP in the CA1 region of hippocampus induced by a brief 1-Hz paired-pulse stimulation (PP-1 Hz, 1 min). In contrast to L-LTP induced by HFS, the late phase of PP-1 Hz LTP does not exist in young adult animals. Rather, it emerges and becomes enhanced in an age-related way. Thus, in 1.5- to 2-mo-old mice, a brief PP-1 Hz stimulation induces only a short lasting LTP, decaying to baseline in about 90 min. By contrast, PP-1 Hz stimulation induces an enduring and protein synthesis dependent LTP in 12- to 18-mo-old mice. The PP-1 Hz-induced L-LTP is dependent on NMDA receptor activation, requires voltage-dependent calcium channels, and is modulated by dopamine D1/D5 receptors. Because memory ability declines with aging, the age-related enhancement of L-LTP induced by PP-1 Hz stimulation indicates that this form of L-LTP appears to be inversely correlated with memory ability.     

Dishabituation in Aplysia can involve either reversal of habituation or superimposed sensitization

Dishabituation has been thought to be due either to reversal of the process of habituation or to a second process equivalent to sensitization superimposed on habituation. One way to address this question is by testing whether dishabituation and sensitization can be dissociated. Previous studies using this approach in Aplysia have come to different conclusions about the nature of dishabituation, perhaps because those studies differed in many respects, including (1) whether they also observed transient behavioral inhibition, and (2) whether they used test stimuli that activated the LE siphon sensory neurons or as yet unidentified sensory neurons. To attempt to resolve the apparent contradictions between the previous studies, we have explored the importance of these two factors by performing a parametric study of dishabituation and sensitization of gill withdrawal in a simplified preparation that does not exhibit transient behavioral inhibition, using two different test stimuli that are known to activate the LE (Touch) or unidentified (Not Touch) sensory neurons. We find that dishabituation and sensitization in this preparation have similar time courses and generally similar functions of shock intensity. However, under one condition, with the Not Touch stimulus 2.5 min after the shock, dishabituation has a reverse effect of shock intensity. Additional analyses suggest that dishabituation with the Not Touch stimulus 2.5 min after the shock is due to reversal of habituation, whereas 12.5 min after the shock, dishabituation is due to superimposed sensitization. These results thus suggest that dishabituation may involve either process in the same preparation, and begin to define the conditions that favor one or the other.     

Single-trial EEG-fMRI reveals the dynamics of cognitive function

Two major non-invasive techniques in cognitive neuroscience, electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), have complementary advantages with regard to their spatial and temporal resolution. Recent hardware and software developments have made it feasible to acquire EEG and fMRI data simultaneously. We emphasize the potential of simultaneous EEG and fMRI recordings to pursue new strategies in cognitive neuroimaging. Specifically, we propose that, by exploiting the combined spatiotemporal resolution of the methods, the integration of EEG and fMRI recordings on a single-trial level enables the rich temporal dynamics of information processing to be characterized within spatially well-defined neural networks.     

The role of response selection in sequence learning

We investigated the role of response selection in sequence learning in the serial reaction time (SRT) task, by manipulating stimulus-response compatibility. Under conditions in which other types of learning, like perceptual, response-based, and response-effect learning, were unaffected, sequence learning was better with an incompatible than with a compatible stimulus-response mapping. Stimulus discriminability, on the other hand, had no influence on the amount of sequence learning. This indicates that the compatibility effects cannot be accounted for by a different level of task difficulty. Relating our results to the dimensional overlap model (Kornblum, Hasbroucq, & Osman, 1990), which assumes that incompatible stimulus-response mappings require more controlled response selection than do compatible stimulus-response mapping, we suggest that sequence learning in the SRT task is particularly effective when response selection occurs in a controlled way.     

Middle childhood and adolescent contextual and personal predictors of adult educational and occupational outcomes: a mediational model in two countries

The authors examined the prediction of occupational attainment by age 40 from contextual and personal variables assessed during childhood and adolescence in 2 participant samples: (a) the Columbia County Longitudinal Study, a study of 856 third graders in a semirural county in New York State that began in 1960, and (b) the Jyv?skyl? Longitudinal Study of Personality and Social Development, a study of 369 eight-year-olds in Jyv?skyl?, Finland, that began in 1968. Both samples were followed up during adolescence and early and middle adulthood. Structural modeling analyses revealed that in both countries, for both genders, children's age 8 cognitive-academic functioning and their parents' occupational status had independent positive long-term effects on the children's adult occupational attainment, even after other childhood and adolescent personal variables were controlled for. Further, childhood and adolescent aggressive behavior negatively affected educational status in early adulthood, which in turn predicted lower occupational status in middle adulthood.     

When sanctions fail to increase cooperation in social dilemmas: considering the presence of an alternative option to defect

Previous social dilemma research has shown that sanctioning defection may enhance cooperation. The authors argue that this finding may have resulted from restricting participants to two behaviors (cooperation and defection). In this article, the authors introduce the concept of a "social trilemma" (a social dilemma in which an alternative option to defect is present) and tested the effect of a sanction. The authors show that a sanction only increased cooperation and collective interests in the traditional social dilemma. In a social trilemma, the sanction failed because it caused some people to choose the alternative option to defect. Moreover, the results indicate that this was especially the case when people did not expect fellow group members to cooperate. In this case, the sanction even worked counterproductive because it decreased collective interests. It is concluded that allowing individuals to consider alternative options to defect can reveal the potential detrimental effects of sanctioning systems for the collective.     

Speed-accuracy trade-offs in myocontrol

Myoelectric (EMG) signals are used in assistive technology for prostheses, computer and domestic control. However, little is known about the capacity of controlling these signals. Specifically, it is unclear whether myocontrol, i.e., the control of myoelectric signals, obeys the same laws as motor control. Neurologically intact adult participants performed pointing tasks with EMG signals captured from the forehead or the hand in two modalities (sustained: stabilize the signal amplitude in the target; impulsion: produce an impulse and return to resting level). In the sustained modality, the time to reach the target (reach time) increased logarithmically with target amplitude, which is compatible with the predictions of Fitts' law. The rate of failure was not significantly affected by target amplitude. In the impulsion modality, the reach time and the rate of failure followed a bow-shaped pattern as a function of target amplitude. Stabilization time in the sustained modality followed a convex (bow-shaped) pattern for the forehead and a concave pattern for the hand. This was the only significant effect of electrode placement in this study. These findings suggest that myocontrol obeys laws that are distinct from those determining motor control, and that the muscular and intra-muscular synergies that produce EMG signals are specific of each pointing modality and target amplitude.     

The classification of violence risk

The Classification of Violence Risk (COVR) is an interactive software program designed to estimate the risk that a person hospitalized for mental disorder will be violent to others. The software leads the evaluator through a chart review and a brief interview with the patient. At the end of this interview, the software generates a report that contains a statistically valid estimate of the patient's violence risk-ranging from a 1% to a 76% likelihood of violence-including the confidence interval for that estimate, and a list of the risk factors that the program took into account to produce the estimate. In this article, the development of the COVR software is described and several issues that arise in its administration are discussed.