Screening for Muir-Torre Syndrome Using Mismatch Repair Protein Immunohistochemistry of Sebaceous Neoplasms

Screening for the Muir-Torre variant of Lynch Syndrome (LS) using Mismatch Repair (MMR) gene immunohistochemistry (IHC) on sebaceous neoplasms (SNs) is technically feasible. To date, research into the clinical utility of MMR IHC for this indication is limited. We conducted a retrospective chart review of 90 patients with MMR IHC completed on at least one SN from January 2005 to May 2010. SNs included were adenomas, epitheliomas, carcinomas and basal and squamous cell carcinomas with sebaceous differentiation. Of the 90 patients, 13 (14 %) had genetically confirmed or fulfilled clinical criteria for a diagnosis of MTS and 51 patients (57 %) presented with an abnormal MMR IHC result (loss of one or more MMR proteins) on at least one SN. Abnormal IHC had a sensitivity of 85 %, specificity of 48 %, positive predictive value (PPV) of 22 % and negative predictive value (NPV) of 95 % when evaluating for MTS. When personal or family history of colorectal cancer (≥2 family members with a history of colorectal cancer) was taken into consideration, ignoring IHC results, sensitivity was 92 %, specificity was 99 %, PPV was 92 % and NPV was 99 %. MMR IHC on SNs when used to screen for MTS has poor diagnostic utility. We recommend that MMR IHC not be performed routinely on SNs when the patient does not have either personal or family history of colorectal cancer.     

The Impact of Strategic Trajectory Optimization on Illusory Target Biases During Goal-Directed Aiming

During rapid aiming, movements are planned and executed to avoid worst-case outcomes that require time and energy to correct. As such, downward movements initially undershoot the target to avoid corrections against gravity. Illusory target context can also impact aiming bias. Here, the authors sought to determine how strategic biases mediate illusory biases. Participants aimed to Müller-Lyer figures in different directions (forward, backward, up, down). Downward biases emerged late in the movement and illusory biases emerged from peak velocity. The illusory effects were greater for downward movements at terminal endpoint. These results indicate that strategic biases interact with the limb-target control processes associated with illusory biases. Thus, multiple control processes during rapid aiming may combine and later affect endpoint accuracy (D. Elliott et al., 2010 Elliott, D., Hansen, S., Grierson, L. E. M., Lyons, J., Bennett, S. J., &; Hayes, S. J. (2010). Goal-directed aiming: two components but multiple processes. Psychological Bulletin, 136, 1023–1044.[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]).     

An MMPI Comparison of Two Groups of Institutionalized Delinquents

Two independent studies compared the MMPI performance of 2 groups of matched institutionalized delinquent boys, those who caused trouble in dormitories (SSs) and those who did not (GGs). In the 1st study, Scale 4 was the only statistically significant scale. Cross-validation found no scales statistically significant. Nineteen items which discriminated between SSs and GGs in the 1st study did not hold up in the cross-validation study. It is concluded that the MMPI has questionable value in discriminating between different levels and types of delinquents.     

A Comparison of the Psychological Entitlement Scale and the Narcissistic Personality Inventory's Entitlement Scale: Relations With General Personality Traits and Personality Disorders

Two studies on the relations between various styles of defense and the power or validity of self-reports on objective personality questionnaires. The power of individual items on the Rotter Internal-External Locus of Control scale to discriminate between subjects defined as internals or externals by a median-cut procedure using the total score was not affected by the presence Or absence of a projective defensive style. However, the presence of repressive tendencies did appear to restrict item power. Prediction from two achievement scales taken from Gough's California Psychological Inventory was not influenced by level of repression, was affected somewhat adversely by a projective style, and was most clearly contaminated by a rationalizing defense. It was proposed that the differential effects of defensive styles upon the validity of personality tests depended upon the convergence or divergence of the cognitive operations involved in the type of defense and in the type of personality measure.     

An effectiveness trial of a new enhanced dissonance eating disorder prevention program among female college students

Objective

Efficacy trials indicate that a dissonance-based prevention program in which female high school and college students with body image concerns critique the thin-ideal reduced risk factors, eating disorder symptoms, and future eating disorder onset, but weaker effects emerged from an effectiveness trial wherein high school clinicians recruited students and delivered the program under real-world conditions. The present effectiveness trial tested whether a new enhanced dissonance version of this program produced larger effects when college clinicians recruited students and delivered the intervention using improved procedures to select, train, and supervise clinicians.

Method

Young women recruited from seven universities across the US (N = 408, M age = 21.6, SD = 5.64) were randomized to the dissonance intervention or an educational brochure control condition.

Results

Dissonance participants showed significantly greater decreases in risk factors (thin-ideal internalization, body dissatisfaction, dieting, negative affect) and eating disorder symptoms versus controls at posttest and 1-year follow-up, resulting in medium average effect size (d = .60). Dissonance participants also reported significant improvements in psychosocial functioning, but not reduced health care utilization or unhealthy weight gain.

Conclusions

This novel multisite effectiveness trial with college clinicians found that the enhanced dissonance version of this program and the improved facilitator selection/training procedures produced average effects that were 83% larger than effects observed in the high school effectiveness trial.     

Temperament in early childhood and peer interactions in third grade: The role of teacher–child relationships in early elementary grades

Children's interactions with peers in early childhood have been consistently linked to their academic and social outcomes. Although both child and classroom characteristics have been implicated as contributors to children's success, there has been scant research linking child temperament, teacher–child relationship quality, and peer interactions in the same study. The purpose of this study is to examine children's early temperament, rated at preschool age, as a predictor of interactions with peers (i.e., aggression, relational aggression, victimization, and prosociality) in third grade while considering teacher–child relationship quality in kindergarten through second grades as a moderator and mediator of this association. The sample (N = 1364) was drawn from the NICHD Study of Early Child Care and Youth Development. Results from structural equation models indicated that teacher–child conflict in early elementary grades mediated links between children's temperament and later peer interactions. Findings underscore the importance of considering children's temperament traits and teacher–child relationship quality when examining the mechanisms of the development of peer interactions.     

Thinking animals, disagreement, and skepticism

According to Eric Olson, the Thinking Animal Argument (TAA) is the best reason to accept animalism, the view that we are identical to animals. A novel criticism has been advanced against TAA, suggesting that it implicitly employs a dubious epistemological principle. I will argue that other epistemological principles can do the trick of saving the TAA, principles that appeal to recent issues regarding disagreement with peers and experts. I conclude with some remarks about the consequence of accepting these modified principles, drawing out some general morals in defending animalism.     

In defense of nativism

This paper takes a fresh look at the nativism–empiricism debate, presenting and defending a nativist perspective on the mind. Empiricism is often taken to be the default view both in philosophy and in cognitive science. This paper argues, on the contrary, that there should be no presumption in favor of empiricism (or nativism), but that the existing evidence suggests that nativism is the most promising framework for the scientific study of the mind. Our case on behalf of nativism has four parts. (1) We characterize nativism’s core commitments relative to the contemporary debate between empiricists and nativists, (2) we present the positive case for nativism in terms of two central nativist arguments (the poverty of the stimulus argument and the argument from animals), (3) we respond to a number of influential objections to nativist theories, and (4) we explain the nativist approach to the conceptual system.