Imaging or imagining? A neuroethics challenge informed by genetics

From a twenty-first century partnership between bioethics and neuroscience, the modern field of neuroethics is emerging, and technologies enabling functional neuroimaging with unprecedented sensitivity have brought new ethical, social and legal issues to the forefront. Some issues, akin to those surrounding modern genetics, raise critical questions regarding prediction of disease, privacy and identity. However, with new and still-evolving insights into our neurobiology and previously unquantifiable features of profoundly personal behaviors such as social attitude, value and moral agency, the difficulty of carefully and properly interpreting the relationship between brain findings and our own self-concept is unprecedented. Therefore, while the ethics of genetics provides a legitimate starting point--even a backbone--for tackling ethical issues in neuroimaging, they do not suffice. Drawing on recent neuroimaging findings and their plausible real-world applications, we argue that interpretation of neuroimaging data is a key epistemological and ethical challenge. This challenge is two-fold. First, at the scientific level, the sheer complexity of neuroscience research poses challenges for integration of knowledge and meaningful interpretation of data. Second, at the social and cultural level, we find that interpretations of imaging studies are bound by cultural and anthropological frameworks. In particular, the introduction of concepts of self and personhood in neuroimaging illustrates the interaction of interpretation levels and is a major reason why ethical reflection on genetics will only partially help settle neuroethical issues. Indeed, ethical interpretation of such findings will necessitate not only traditional bioethical input but also a wider perspective on the construction of scientific knowledge.     

Semantics for existential graphs

This paper examines Charles Peirce's graphical notation for first-order logic with identity. The notation forms a part of his system of existential graphs, which Peirce considered to be his best work in logic. In this paper a Tarskian semantics is provided for the graphical system.     

The Role of Candidate Sex in Voter Decision-Making

Recent studies investigating the role of candidate sex in voter decision-making have not found discrimination against women candidates. Thus, voter bias is often dismissed as part of the explanation for the drastic underrepresentation of women in high elective office. In a dual sample of Wyoming and California college students, bias against women candidates was found to be a factor in the vote choice. Studies that examine only one sample of voters in one region may be prematurely dismissing the possible existence of gender discrimination in some regions or cultures within the United States.     

Toward a Psychology of Loss

This article argues for the development of an interdisciplinary psychology of loss that is focused on people's pervading commonsense experience and recognition of loss in their own and others' lives. This field may be defined as broader than related fields such as traumatology, thanatology, and stress and coping. The psychology of loss focuses on the perception of major loss deriving from events such as death and divorce, but also on the perception of major loss in connection with such diverse phenomenna as loss of employment, los of bodily functioning, and being the target of violence or prejudice, including genocide. An important research topic for this field concerns people's stories of how major losses are interrelated in their lives. It is argued that perceived loss is a critical phenomenal state that must be dealt with in adaptation to most significant stressors.     

Using Brief Functional Analysis to Select Interventions for Oral Reading

Reading interventions were applied in a brief multielement format to examine their effectiveness at improving the oral reading fluency of three students referred for reading problems. Although each student had different profiles across experimental analyses, effective interventions were identified and a mini-replication confirmed the pattern of results in each case.     

Groups as gatekeepers to genomic research: conceptually confusing, morally hazardous, and practically useless

Some argue that human groups have a stake in the outcome of population-genomics research and that the decision to participate in such research should therefore be subject to group permission. It is not possible, however, to obtain prior group permission, because the actual human groups under study, human demes, are unidentifiable before research begins. Moreover, they lack moral standing. If identifiable social groups with moral standing are used as proxies for demes, group approval could be sought, but at the expense of unfairly exposing these surrogates to risks from which prior group approval is powerless to protect them. Unless population genomics can proceed without targeting socially defined groups, or can find other ways of protecting them, it may fall to individuals to protect the interests of the groups they care about, and to scientists to warn their subjects of the need to do so.     

Courseware for observational research (COR): A new approach to teaching naturalistic observation

Naturalistic observation is one of the most basic and widely used techniques of scientific research, yet it often receives only a cursory treatment in the research methods course. In this paper, we describe a new interactive multimedia software program that teaches interval, frequency, and duration coding with the use of brief digitized video clips and model check sheets. The program teaches basic observational techniques by leading students through the stages of developing a behavioral coding scheme, collecting data, establishing interrater reliability, and analyzing with chi square. It also has a laboratory component that allows students to practice their skills.     

Eye movement of perceivers during audiovisualspeech perception

Perceiver eye movements were recorded during audiovisual presentations of extended monologues. Monologues were presented at different image sizes and with different levels of acoustic masking noise. Two clear targets of gaze fixation were identified, the eyes and the mouth. Regardless of image size, perceivers of both Japanese and English gazed more at the mouth as masking noise levels increased. However, even at thehighest noise levels and largest image sizes, subjects gazed at the mouth only about half the time. For the eye target, perceivers typically gazed at one eye more than the other, and the tendency became stronger at higher noise levels. English perceivers displayed more variety of gaze-sequence patterns (e.g., left eye to mouth to left eye to right eye) and persisted in using them at higher noise levels than did Japanese perceivers. No segment-level correlations were found between perceiver eye motions and phoneme identity of the stimuli.     

Multiple spatial codes and temporal overlap in choice-reaction tasks

Experiments by Umiltà and Liotti (1987) and Lamberts, Tavernier, & d'Ydewalle (1992) examined the Simon effect (an influence of irrelevant stimulus location on reaction time) as a function of multiple frames of reference. The Simon effect was absent for all reference frames in the former experiment, leading Stoffer (1991) to propose that a spatial code is formed only if the last step in directing attention to the imperative stimulus is a lateral shift. However, the Simon effect was evident for all frames in the latter experiment. Hommel (1994) proposed that the multiple spatial codes implied by Lamberts et al.'s findings were also activated in Umiltà and Liotti's experiment but had decayed by the time the relevant stimulus information had been identified. Experiments 1, 2, and 3 examined these accounts of attention shifting, multiple codes, and temporal overlap for variations of the Simon task in which the stimulus could occur in one of either eight or four possible stimulus locations. Three stimulus sets that differed in ease of discriminability were used in each experiment. Experiments 1 and 2 were replications and extensions of those of Lamberts et al. and Umiltá and Liotti, respectively. In both experiments, two boxes, with a stimulus inside of one, appeared simultaneously, and the subject was to respond to the identity of the stimulus. Experiment 3 used a procedure in which the four stimulus locations were demarcated by three vertical lines. Two of the three experiments showed Simon effects with respect to multiple frames of reference, and the magnitude of these effects was a decreasing function of the difficulty of stimulus discriminability. Spatial compatibility proper was examined in Experiment 4 using the same layout as Experiment 3. In this case, only the relevant frame of reference was coded. On the whole, the results indicate that multiple codes are formed, but not automatically, and that those codes decay when irrelevant.