Preserved spatial memory in old rats survives 10 months without training

Aged rats with extensive prior training on the radial maze retain the capacity for accurate spatial working memory (WM) for at least 3 months without practice. To investigate the temporal limits of this influence of prior experience we compared the reacquisition of spatial WM by a group of experienced 21.5-month-old rats to the original acquisition by naive 3-month-old rats. The aged rats had received 225 radial maze tests between 3 and 11 months of age. Despite 10 months without practice the old rats rapidly reacquired critical performance. Their reacquisition was markedly superior to original learning by the young rats, even when delays as long as 5 h were imposed between the rats' fourth and fifth choices during the daily tests in the eight-arm maze. Additional tests showed that neither young nor old rats employed a response strategy to maintain accurate spatial WM performance. Experience clearly confers long-lived protection against the otherwise deleterious effects of aging on spatial WM, but the mechanism by which this influence arises is unknown.     

High maternal aggression in dwarf hamsters (Phodopus campbelli and P. sungorus)

The defense of offspring, termed maternal aggression, is a highly conserved behavior in mammals, including rodents. This study examined relative levels of maternal aggression in two closely related dwarf hamster species, Phodopus campbelli and P. sungorus, that normally inhabit high latitude, boreal environments. When tested with first litters and with the breeder male remaining with the female (for P. campbelli the male is necessary for successful rearing of offspring), both species exhibited high levels of maternal aggression with average duration of aggressive behavior>80 sec for a 10 min test. For P. sungorus, males are not required to rear offspring. P. sungorus females with either one or multiple litters (singly housed after impregnation) exhibited significantly higher levels of aggression (>300 sec) relative to females co‐housed with the sires. In terms of species differences in attack style, P. campbelli exhibited a boxing or clawing strategy for ～50% of total attack time, but for P. sungorus, this form of attack occurred<5% of the time. For P. sungorus, attacks to the vulnerable belly and flank constituted>90% of all attacks, but these regions were attacked ～50% of the time for P. campbelli. A survey of levels of maternal aggression of rodents in other genera suggests that maternal aggression in Phodopus is at the high end of the spectrum. Results of this study suggest that the presence of the breeder male may actually suppress aggression in P. sungorus. This fact, as well as its high level of aggression and its distant relationship to mice and rats, suggest P. sungorus as a possible model for future studies on the neurobiological basis of maternal aggression. The relationship between the high rates of maternal aggression and life history strategy in Phodopus is discussed. Aggr. Behav. 00:000–000, 2005. © 2005 Wiley‐Liss, Inc.     

Being Employed by a Co-national: A Cul-de-sac or a Short Cut to the Main Road of the Labour Market?

This paper analyses the impact of working in an ethnic economy on subsequent labour market performance for newly arrived immigrants. Is it a short cut to the labour market or does it lock immigrants into low income jobs? Working in an ethnic economy is defined as being employed by a self-employed co-national. The comparison group is a matched sample of newly arrived immigrants who were without employment during the same period. Swedish panel data for the period 1998?C2005 are used, and the sample is restricted to male immigrants, 20?C55?years of age. Using propensity score matching, we find that immigrants who were employed by self-employed co-nationals are more likely to be employed in the near future, but that the types of employment they have are associated with lower incomes. Many continue to be employed by self-employed co-nationals or become self-employed themselves.     

Patents and ethics: Is it possible to be balanced?

In this presentation, principles of ethics are confronted with the desire of the inventor to make a profit. To this end the presentation is focused on patent protection. Patents should guarantee the return of an inventor’s investment and profit and, on the other side, ensure availability — by patent disclosure — of the invention for the society when the patent terminates. Recent patent applications made by inventors are infringing this principle and societies are paying an unexpected price for these practices. Patent claims are too broad and disclosures too poor. Extreme examples will be discussed. An earlier version of this paper was presented at an international conference, “The Ethics of Intellectual Property Rights and Patents,” held in Warsaw, Poland on 23–24 April, 2004.     

Mood-congruent biases in facial emotion perception and their gender dependence

Due to mood-congruency effects, we expect the emotion perceived on a face to be biased towards one's own mood. But the findings in the scant literature on such mood effects in normal healthy populations have not consistently and adequately supported this expectation. Employing effective mood manipulation techniques that ensured that the intended mood was sustained throughout the perception task, we explored mood-congruent intensity and recognition accuracy biases in emotion perception. Using realistic face stimuli with expressive cues of happiness and sadness, we demonstrated that happy, neutral and ambiguous expressions were perceived more positively in the positive than in the negative mood. The mood-congruency effect decreased with the degree of perceived negativity in the expression. Also, males were more affected by the mood-congruency effect in intensity perception than females. We suggest that the greater salience and better processing of negative stimuli and the superior cognitive ability of females in emotion perception are responsible for these observations. We found no evidence for mood-congruency effect in the recognition accuracy of emotions and suggest with supporting evidence that past reports of this effect may be attributed to response bias driven by mood.     

Psychometric properties and factor structure of the Fear Questionnaire phobia subscale items in two normative samples

Normative data for the Fear Questionnaire (Marks & Mathews, 1979), a popular self-report instrument measuring phobic concerns, were collected from both a community and a collegiate sample. The covariation and internal consistency of the blood-injury phobia (BI), social phobia (SO), and agoraphobia (AG) subscales were assessed in each sample, and the factor structure of the items from these three subscales was examined. Results indicated that, in general, community subjects reported more phobic concerns than did collegiate subjects, and females reported greater phobic concerns than did males. Results from confirmatory factor analyses suggest that the three factors of BI, SO, and AG did not emerge from either data set. Follow-up exploratory factor analyses did identify the general factors of blood-injury phobia and agoraphobia. Normative data from the present study are compared to those obtained previously, and directions for future research are provided.     

Age-related enhancement of a protein synthesis-dependent late phase of LTP induced by low frequency paired-pulse stimulation in hippocampus

Protein synthesis-dependent late phase of LTP (L-LTP) is typically induced by repeated high-frequency stimulation (HFS). This form of L-LTP is reduced in the aged animal and is positively correlated with age-related memory loss. Here we report a novel form of protein synthesis-dependent late phase of LTP in the CA1 region of hippocampus induced by a brief 1-Hz paired-pulse stimulation (PP-1 Hz, 1 min). In contrast to L-LTP induced by HFS, the late phase of PP-1 Hz LTP does not exist in young adult animals. Rather, it emerges and becomes enhanced in an age-related way. Thus, in 1.5- to 2-mo-old mice, a brief PP-1 Hz stimulation induces only a short lasting LTP, decaying to baseline in about 90 min. By contrast, PP-1 Hz stimulation induces an enduring and protein synthesis dependent LTP in 12- to 18-mo-old mice. The PP-1 Hz-induced L-LTP is dependent on NMDA receptor activation, requires voltage-dependent calcium channels, and is modulated by dopamine D1/D5 receptors. Because memory ability declines with aging, the age-related enhancement of L-LTP induced by PP-1 Hz stimulation indicates that this form of L-LTP appears to be inversely correlated with memory ability.     

Dishabituation in Aplysia can involve either reversal of habituation or superimposed sensitization

Dishabituation has been thought to be due either to reversal of the process of habituation or to a second process equivalent to sensitization superimposed on habituation. One way to address this question is by testing whether dishabituation and sensitization can be dissociated. Previous studies using this approach in Aplysia have come to different conclusions about the nature of dishabituation, perhaps because those studies differed in many respects, including (1) whether they also observed transient behavioral inhibition, and (2) whether they used test stimuli that activated the LE siphon sensory neurons or as yet unidentified sensory neurons. To attempt to resolve the apparent contradictions between the previous studies, we have explored the importance of these two factors by performing a parametric study of dishabituation and sensitization of gill withdrawal in a simplified preparation that does not exhibit transient behavioral inhibition, using two different test stimuli that are known to activate the LE (Touch) or unidentified (Not Touch) sensory neurons. We find that dishabituation and sensitization in this preparation have similar time courses and generally similar functions of shock intensity. However, under one condition, with the Not Touch stimulus 2.5 min after the shock, dishabituation has a reverse effect of shock intensity. Additional analyses suggest that dishabituation with the Not Touch stimulus 2.5 min after the shock is due to reversal of habituation, whereas 12.5 min after the shock, dishabituation is due to superimposed sensitization. These results thus suggest that dishabituation may involve either process in the same preparation, and begin to define the conditions that favor one or the other.