Exploration and avoidance in rats with lesions in amygdala and piriform cortex

Lesions localized to specific areas of the amygdala and overlying cortex in rats produced differential effects in several behavioral tasks. Three different types of lesions were tested: central, basolateral, and cortex lateral to the amygdala. Lesions restricted to the central nucleus produced increased activity on all parameters studied in an open-field test, but the other two groups were not changed. In one-way active avoidance all three groups with lesions showed deficits. The most pronounced change was observed in the central group. All groups showed the same degree of retention loss, but in forced extinction of one-way active avoidance after retraining, the cortical and basolateral groups were most defective. A fear-reduction hypothesis is proposed for the central lesion. The basolateral and cortical areas may be more specifically involved in passive avoidance behavior.     

Differential indications for desipramine--results of a controlled multiclinical study]

The antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective symptoms, which was not detectable for the inhibition of drive. The tachythymoleptic action of desipramine is discussed with reference to these results. Evaluation of the possibility of controlling affects shows different ranges of activity of desipramine and imipramine, with desipramine influencing especially negative psychoenergetic symptoms in the area of drives and emotions and imipramine, restrictive symptoms in addition to differential phenomena of the psychomotor expression.     

Why child neuropsychiatry?]

The author gives a brief survey of the development of Child-Neuropsychiatry in the G.D.R. and subsequently gives reasons for the decision in favor of the unity of neurology and psychiatry as applied to children and juveniles, which is in contrast to developments in other countries. In addition to hygienic, economic, organizational, and medical considerations, this decision was also determined by the fact that a Child-Neuropsychiatrist must, in his practical work as a subspecialist, be able to head a multiprofessional team and, thus, help assure optimum development of a child's personality.     

Parameters for vowel substitutions in Broca''s aphasia

Most phonological investigations of aphasic speech have focused on consonants. In this study, the vowel substitutions of five English-speaking Broca's aphasics were investigated with respect to several major explanatory hypotheses. An important possible motivating factor for aphasic substitutions, phonological environment, is an unlikely origin for these errors, since most substitutions occur along the paradigmatic axis. Another prominent hypothesis, markedness, also has no predictive power for the data of this sample. However, an analysis of the five Chomsky and Halle (1968, (The Sound Pattern of English), New York: Harper and Row) vowel features indicates that the two features for vowel height are selectively impaired: There is a strong tendency for lower vowels to replace higher targets. Moreover, the substitution sounds tend to be close to their target sounds along the height axis. Four possible hypotheses are advanced to account for this consistent lowering tendency.     

The influence of catch trial frequency on simple reaction time

The major purpose of the present investigation was to examine the combined influence of variations in foreperiod length (1.0, 5.0 sec) and catch trial frequency (0.0, 0.1, 0.2) on simple reaction time (RT) magnitude when verbal mediation was permitted and when it was not. A significant foreperiod length, catch trial frequency, mediation type interaction was obtained supporting the notion that all three factors influence a common process (i.e. Sternberg 1969), here called ‘preparation’. More specifically, for the non-mediation group, foreperiod length and catch trial frequency had both additive (0.0 vs 0.1) and interactive (0.1 vs 0.2) effects on mean simple RT while only catch trial frequency significantly altered simple RT for the mediating group. In all instances, mean simple RT increased significantly when some catch trials were employed as opposed to when none were used, a finding which was interpreted as reflecting an induced preparation decrement upon the introduction of catch trials.