The Visual Spatial Learning Test: Differential impairment during the premanifest and manifest stages of Huntington's disease

Visual spatial memory was assessed using the Visual Spatial Learning Test (VSLT) in individuals with mild to moderate Huntington's disease (HD), pre‐manifest gene carriers for HD, and demographically similar controls. The VSLT has been demonstrated to be a valid, normed measure of non‐verbal memory involving minimal motoric responses. The VSLT assesses immediate and delayed memory for designs, positions of the designs, and design/position associations. The HD group was significantly impaired (p < .05) relative to both the control and Pre‐HD groups on immediate and delayed memory for the designs, positions, and design/position associations. Although there were no differences between the Pre‐HD and control groups on immediate or delayed memory for designs or positions, the Pre‐HD group was significantly impaired (p < .05) relative to the control group on immediate and delayed memory for design/position associations. The results offer novel insight into a relatively unexamined memory deficit that may occur in gene carriers for HD prior to phenoconversion. The data indicate that the VSLT may be a useful measure of visuospatial memory during the premanifest and manifest stages of HD.     

Genetic testing and human subjectivity

This article offers a brief overview of how methods of DNA testing are reframing what it means to be a living being in a living world. It is no longer the case that genetic technologies objectify life in such a way as to deny something essential to human subjectivity. The style of reasoning of the life sciences today is characterised by complexity, dynamism and emergence. This requires rethinking the relationship between technology, society and subjectivity. Genetic testing is a social and symbolic practice through which notions of identity and relatedness are reconfigured in terms of being genetically at risk. Far from reducing subjectivity to one's biological destiny, genetic technologies have consequences in terms of not only governing others to govern their risk wisely, but also aligning conduct with Western liberal values of autonomy, responsibility and choice. New pastors and gatekeepers of genetic information have assembled around these technologies where psychology plays a key role in facilitating autonomy and instilling a sense of genetic responsibility. Nevertheless, the increasing capitalization of genomics is moving genetic testing beyond these clinical enclosures of control into the domain of consumer choice, creating new forms of subjectification, citizenship and community.     

Individual Differences in Commitment to Value‐Based Beliefs and the Amplification of Perceived Belief Dissimilarity Effects

The commitment to beliefs (CTB) framework (Maxwell‐Smith & Esses, 2012) proposes that there are individual differences in the extent to which people generally follow beliefs that are a reflection of their values. The current research hypothesized that CTB would amplify the effects of perceived belief dissimilarity or incompatibility, such that individuals higher in CTB would display more pronounced reactions to belief‐relevant groups, events, or individuals seen as incompatible with their value‐based beliefs. We tested our hypothesis in three studies that assessed participants' CTB and their perceptions of belief dissimilarity or incompatibility with regard to other religious groups (Study 1), political parties during a national election (Study 2), and their romantic partner (Study 3). CTB amplified the effects of perceived belief dissimilarity or incompatibility on people's biases toward other religious groups, voting intentions and behavior in a national election, and their evaluative and behavioral responses toward their romantic partner. These results collectively suggest that perceptions of belief dissimilarity or incompatibility are particularly important cues for individuals with higher levels of CTB as they encounter other people or events that are relevant to their beliefs.     

Adverse Events in Emerging Adulthood Are Associated with Increases in Neuroticism

Previous studies have produced mixed results when examining whether experiencing an adverse event can lead to changes in Neuroticism. We sought to examine this effect when (a) the event was relatively recent, (b) the event occurred during a relatively early development stage (i.e., emerging adulthood), and (c) the event was severely adverse. A sample of 1,108 undergraduates completed three measures of Neuroticism twice, separated by approximately 3 months, and indicated the most traumatic or adverse event they experienced during the intervening 3 months. We examined two operationalizations of adverse events: one that is more objectively defined (indicated experiencing a trauma listed on a trauma history measure) and another more subjectively defined (participant ratings of event centrality). The results revealed that high Neuroticism at Time 1 predicted future exposure to both types of adverse events. Critically, participants who experienced either type of adverse event during the semester reported significant increases in Neuroticism. Experiencing a high event centrality event was also associated with small increases in the personality traits Openness to Experience and Conscientiousness. The results are discussed in terms of the conditions necessary for adverse events to affect personality traits.     

The relationship between the Five‐Factor Model personality traits and peptic ulcer disease in a large population‐based adult sample

The current study examined the relationship between the Five‐Factor Model personality traits and physician‐confirmed peptic ulcer disease (PUD) diagnosis in a large population‐based adult sample, controlling for the relevant behavioral and sociodemographic factors. Personality traits were assessed by participants themselves and by knowledgeable informants using the NEO Personality Inventory‐3 (NEO PI‐3). When controlling for age, sex, education, and cigarette smoking, only one of the five NEO PI‐3 domain scales – higher Neuroticism – and two facet scales – lower A1: Trust and higher C1: Competence – made a small, yet significant contribution (p < 0.01) to predicting PUD in logistic regression analyses. In the light of these relatively modest associations, our findings imply that it is certain behavior (such as smoking) and sociodemographic variables (such as age, gender, and education) rather than personality traits that are associated with the diagnosis of PUD at a particular point in time. Further prospective studies with a longitudinal design and multiple assessments would be needed to fully understand if the FFM personality traits serve as risk factors for the development of PUD.     

Feuerbach's theory of object‐relations and its legacy in 20th century post‐Hegelian philosophy

This paper focuses on the way in which Feuerbach's attempt to develop a naturalistic, realist remodeling of Hegel's relational ontology, which culminated in his own version of “sensualism”, led him to emphasize the vulnerability of the subject and the role of affectivity, thus making object‐dependence a constitutive feature of subjectivity. We find in Feuerbach the first lineaments of a philosophical theory of object‐relations, one that anticipates the well‐known psychological theory of the same name, but one that also offers a broader metaphysical basis in which all types of “essential objects” are shown to matter to subjectivity. This Feuerbachian theory of object‐relations, the paper then argues, foreshadows a number of important developments in 20th century post‐Hegelian philosophy. In it can be found an anticipation of Adorno's later theory of mimesis. Equally, this theory already emphasizes the “libidinal” nature of intentionality, in a way that announces Merleau‐Ponty's ontology of the flesh. Finally, the last section of the article proposes a model with which we might reconstruct the way in which object‐relations and self‐relations can be brought together consistently. In this instance, Feuerbach uses concepts that announce Freud's notion of “primary narcissism”. One contemporary philosopher who has proposed a sophisticated model of subjectivity, in which primary narcissism is shown to complement object‐dependence, is Axel Honneth. The last section argues that Feuerbach's full image of subjective identity as reciprocal scaffolding of self‐ and object‐relations reminds strongly of Honneth's core concept of “positive self‐relation”.