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Caryn Lerman Peter G Shields E Paul Wileyto Janet Audrain Larry H Hawk Angela Pinto Susan Kucharski Shiva Krishnan Ray Niaura Leonard H Epstein 《Health psychology》2003,22(5):541-548
This study examined the role of dopaminergic genes in prospective smoking cessation and response to bupropion treatment in a placebo-controlled clinical trial. Smokers of European ancestry (N=418) provided blood samples for genetic analysis and received either bupropion or placebo (10 weeks) plus counseling. Assessments included the dopamine D2 receptor (DRD2) genotype, dopamine transporter (SLC6A3) genotype, demographic factors, and nicotine dependence. Smoking status was verified at the end of treatment (EOT) and at 6-month follow-up. The results provided evidence for a significant DRD2 * SLC6A3 interaction effect on prolonged smoking abstinence and time to relapse at EOT, independent of treatment condition. Such effects were no longer significant at 6-month follow-up, however. These results provide the first evidence from a prospective clinical trial that genes that alter dopamine function may influence smoking cessation and relapse during the treatment phase. 相似文献
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Patterns of vibrotactile stimulation were delivered to the index fingertips of naive blindfolded subjects. The attributions made by these subjects when they were allowed to experience transformations of vibrotactile stimulation correlated with self-movement were assessed. Although the subjects became aware of the relationship between self-movement and stimulation transformation, they never developed the hypothesis of distal attribution, ie the hypothesis that the ultimate cause of their vibrotactile experience was an encounter with an object in the environment. It is proposed that further investigations of the course of acquisition of distal attribution in the situation described may be instructive in the study of externalization in other modalities. 相似文献
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