Neuropsychological tools to predict conversion from amnestic mild cognitive impairment to dementia. The TREDEM Registry

Most of the studies about conversion from Mild cognitive impairment (MCI) to dementia have focused on amnestic MCI (aMCI) which is considered a preclinical phase of Alzheimer’s disease. The aim of the present study was to identify neuropsychological tools that would best predict conversion from aMCI to dementia. Fifty-five aMCI subjects on the Treviso Dementia Registry were investigated. They underwent a neuropsychological evaluation during their first assessment and again at follow-up. Cox proportional-hazard regression models were created to measure the association between the dependent variable (dementia diagnosis or MCI status maintenance) and the neuropsychological test scores at baseline. The sample (28 women and 27 men; mean age 76.82 ± 5.88 years; education 7.62 ± 3.99 years) was observed for an average time of 2.17 ± 1.25 years. A Cox backward stepwise regression showed that the Rey Auditory Verbal Learning Test, Delayed Recall (p = .041) and Semantic Verbal Fluency tests (p = .031) appear to be useful in predicting conversion to dementia.     

Subjectivity,health and gender: an approach to chronified pain through the Psychosocial Gender Diagnostic methodology / Subjetividad,salud y género: una aproximación al dolor cronificado mediante la metodología del Diagnóstico Psicosocial de Género

Abstract

This paper bases itself on a psychological perspective to make a theoretical and methodological proposal that shifts the concept of health towards the crossing point between biomedical and social sciences. To that end, it is suggested that the concept of Subjectivity should be placed at the centre of the discipline of psychology, understanding it from the theoretical perspective that intersects between post-structuralism, psycho-dynamic theory and gender. The objective of the article is to make this proposal through a case study about chronic pain without organic cause, an emerging, contemporary, controversial malaise that is becoming increasingly common, called Fibromyalgia in the biopsychomedical field, and which affects mainly — but not only — women. In order to pursue this goal, a new methodological instrument was developed: the psychosocial gender diagnostic, oriented toward capturing the dynamics of chronic pain. This methodology facilitates the integration of the connections between subjectivity, gender and health, while at the same time problematizes the excessive medicalization of modern day life.     

Does Father Know Best? A Formal Model of the Paternal Influence on Childhood Social Anxiety

We explore paternal social anxiety as a specific risk factor for childhood social anxiety in a rational optimization model. In the course of human evolution, fathers specialized in external protection (e.g., confronting the external world) while mothers specialized in internal protection (e.g., providing comfort and food). Thus, children may instinctively be more influenced by the information signaled by paternal versus maternal behavior with respect to potential external threats. As a result, if fathers exhibit social anxiety, children interpret it as a strong negative signal about the external social world and rationally adjust their beliefs, thus becoming stressed. Under the assumption that paternal signals on social threats are more influential, a rational cognitive inference leads children of socially anxious fathers to develop social anxiety, unlike children of socially anxious mothers. We show in the model that mothers cannot easily compensate for anxious paternal behavior, but choose to increase maternal care to maintain the child’s wellbeing. We discuss research directions to test the proposed model as well as implications for the prevention and treatment of child social anxiety.     

Coherence without additivity

The Dutch book argument is a coherence condition for the existence of subjective probabilities. This paper gives a general framework of analysis for this argument in a nonadditive probability setting. Particular cases are given by comonotonic and affinely related Dutch books that lead to Choquet expectations and Min expectations.     

Is severe obesity a form of addiction? Rationale, clinical approach, and controlled clinical trial.

For many, obesity is just a problem of energy input and expenditure: more energy input than expenditure. However, the clinical practice and epidemiological data clearly show that weight control is more complex than expected by this simple equation. This is particularly true in morbid obesity, a form of severe obesity in which a person's Body Mass Index (BMI, kg/m(2)) is over 40. If we compare the definitions and diagnostic criteria for "dependence" and "addiction" with the situation of many severe obese subjects, it is apparent that they match very well. Further, different neurological studies confirm this similarity: both addiction and obesity patients have a deficiency of dopamine receptors. Nevertheless, when we compare many of the actual obesity treatments with the ones used in the area of addictions it is possible to find relevant differences: obesity treatments neither consider different levels of type and intensity of care, nor a multidimensional approach. To overcome these limitations, in this paper we propose a bio-psychosocial approach in which the genetic influence (lack of dopamine receptors) is matched by psychosocial issues (pressure for thinness and diet as main body image dissatisfaction treatment). Further, the paper outlines how this approach may influence the treatment options, by focusing both on the lessons coming from actual addiction treatment and the opportunities offered by virtual reality. Finally, the paper presents and discusses the outcome of a controlled trial, based on the proposed approach, including a 6-month follow-up (211 morbid obese females with a BMI of >40 and a documented history of failures.     

Relations of Age to Cognitive and Motivational Elements of Impulse Control in Boys With and Without Externalizing Behavior Problems

In a cross-sectional study of 83 unmedicated boys, 6 to 16 years of age (M = 10.6, SD = 2.1), attending public (N = 48) and therapeutic schools for behaviorally disturbed children (N = 35), we examined relations of externalizing psychopathology to age-dependent change in performance on cognitive and motivational dimensions of impulse control assessed by laboratory tasks. When we controlled for internalizing symptoms and IQ or school achievement, all children showed improving competence with increasing age on both dimensions over the age range of the sample. Children with externalizing problems performed more poorly on both dimensions at all ages than children without such problems. Comparing age-dependent competence for the two groups, a model of convergent maturation in cognitive aspects of impulse control, and a model depicting a stable deficit in motivational aspects of impulse control in those children with externalizing behavior problems, relative to those without such problems, emerged. Studies of individual growth in impulse control, together with correlates of growth, are needed to validate these observations.Project on Human Development in Chicago Neighborhoods     

Bodily maps of emotions across child development

Different basic emotions (anger, fear, disgust, happiness, sadness, and surprise) are consistently associated with distinct bodily sensation maps, which may underlie subjectively felt emotions. Here we investigated the development of bodily sensations associated with basic emotions in 6‐ to 17‐year‐old children and adolescents (n = 331). Children as young as 6 years of age associated statistically discernible, discrete patterns of bodily sensations with happiness, fear, and surprise, as well as with emotional neutrality. The bodily sensation maps changed from less to more specific, adult‐like patterns as a function of age. We conclude that emotion‐related bodily sensations become increasingly discrete over child development. Developing awareness of their emotion‐related bodily sensations may shape the way children perceive, label, and interpret emotions.     

Legitimate lies: The relationship between omission,commission, and cheating

Across four experiments, we show that when people can serve their self‐interest, they are more likely to refrain from reporting the truth (lie of omission) than actively lie (lie of commission). We developed a novel online “Heads or Tails” task in which participants can lie to win a monetary prize. During the task, they are informed that the software is not always accurate, and it might provide incorrect feedback about their outcome. In Experiment 1, those in the omission condition received incorrect feedback informing them that they had won the game. Participants in commission condition were correctly informed that they had lost. Results indicated that when asked to report any errors in the detection of their payoff, participants in the omission condition cheated significantly more than those in the commission condition. Experiment 2 showed that this pattern of results is robust even when controlling for the perceived probability of the software error. Experiments 3 and 4 suggest that receiving incorrect feedback makes individuals feel more legitimate in withholding the truth, which, in turn, increases cheating.     

Sensitivity to Affective Information and Investors' Evaluation of Past Performance: An Eye‐tracking Study

In the present work, we used the eye‐tracking methodology to investigate how affective reactions influence investment decision making. In addition, we looked at individual differences in terms of people's sensitivity to affective information and how efficiently they regulate it, that is, trait emotional intelligence. We demonstrated that people who are more sensitive to affective information have larger pupil dilation when looking at the past performance of a stock fund. In addition, we also found that participants' larger pupil dilation had an impact on their investment decisions (whether people were more likely to sell their shares, hold on to the investment, or buy more shares). A larger pupil dilation led people to be more consistent and willing to invest more money on a fund regardless from its past performance (positive or negative). We also tested the hypothesis that individuals with a larger pupil dilation should be more influenced by a fund's past performance (e.g., selling their shares more often when the past performance of the fund was negative and buying additional shares more often when the past performance was positive). However, results did not support this explanation. Finally, our data revealed that the effect of individual differences in trait emotional intelligence on investment decisions was significantly mediated by pupil dilation. In the discussion, we explored the relationship between our results and previous evidence on the role of pupil dilation in processing information under uncertainty and the role of affect in decision making. Copyright © 2015 John Wiley & Sons, Ltd.