Patterns of semantic memory impairment in Mild Cognitive Impairment

Although the semantic memory impairment has been largely documented in Alzheimer's disease, little is known about semantic memory in the preclinical phase of the disease (Mild Cognitive Impairment). The purpose of this study was to document the nature of semantic breakdown using a battery of tests assessing different aspects of conceptual knowledge: knowledge about common objects, famous people and famous public events. Results indicate that all domains of semantic memory were impaired in MCI individuals but knowledge about famous people and famous events was affected to a greater extent than knowledge about objects. This pattern of results suggests that conceptual entities with distinctive and unique properties may be more prone to semantic breakdown in MCI. In summary, results of this study support the view that genuine semantic deficits are present in MCI. It could be useful to investigate the etiological outcome of patients failing or succeeding at such tests.     

Development and validation of the predrinking motives questionnaire

Elaborating on instruments for U.S. university students, we developed and validated the predrinking (drinking before going out) motives questionnaire (PMQ) for general populations of young adults. In popular nightlife areas in Switzerland, 316 predrinkers aged 16–25 (48% women) were recruited. Focus group interviews and exploratory and confirmatory factor analyses yielded a three‐factor measure, with a structure that was invariant across linguistic regions, gender, age, and student status. “Fun/intoxication” motives were associated with predrinking but “conviviality” and “facilitation” motives were not. Men scored higher on “facilitation” than women and those from the French‐speaking region scored higher on “conviviality” than German‐speaking participants. Although yet to be replicated in other countries, the PMQ appears to be an appropriate general measure of predrinking motives.     

What Do We See When We See Total Darkness?

Seeing total darkness is a peculiar perceptual state: in it, the subject is visually aware of something while seeming to fail to be aware of anything. Recent treatments of the topic (Sorensen 2008 , Soteriou 2000 ) leave this particular puzzle unsolved. Here, I attempt a solution. Following Dretske, I begin by suggesting that the perceptual report ‘S sees (total) darkness’ is ambiguous between two distinct kinds of perceptual states: epistemic and non‐epistemic. This will lead to an examination of the metaphysics of what is supposed to be seen. I show, on the one hand, the difficulty of reducing the perception of total darkness to the perception of a particular instantiation of a property, and on the other, that it has important similarities with the perception of (non‐particular) ‘stuff’. I propose, finally, that the solution to the puzzle might involve postulating a novel ontological status for total darkness: that of a ‘concrete universal’. Potential implications of interest for particularism and for naïve realism are suggested.     

Mind the gap: Increasing associations between the self and Blacks with approach behaviors

Although perceived differences between outgroup social categories and the self are often cited as a major contributor to prejudice and intergroup tension, surprisingly few studies have examined ways to improve associations between the self and racial outgroups. The present research investigated one strategy to increase these associations-approach training. Specifically, 3 studies investigated the impact of training participants to conceptually approach Blacks on 3 separate measures: 2 response latency measures indexing the strength of association between the self and Blacks and a psychophysiological measure indexing brain activity in response to Blacks in the context of the self. A fourth study examined the link between earlier research on the impact of approach training on implicit prejudice against Blacks and the current results related to self-Black associations. Together, these findings provided consistent evidence that training in approaching Blacks increases associations between the self and Blacks that in turn reduce implicit prejudice against Blacks.     

Multidimensional scaling of musical time estimations

The aim of this study was to identify the psycho-musical factors that govern time evaluation in Western music from baroque, classic, romantic, and modern repertoires. The excerpts were previously found to represent variability in musical properties and to induce four main categories of emotions. 48 participants (musicians and nonmusicians) freely listened to 16 musical excerpts (lasting 20 sec. each) and grouped those that seemed to have the same duration. Then, participants associated each group of excerpts to one of a set of sine wave tones varying in duration from 16 to 24 sec. Multidimensional scaling analysis generated a two-dimensional solution for these time judgments. Musical excerpts with high arousal produced an overestimation of time, and affective valence had little influence on time perception. The duration was also overestimated when tempo and loudness were higher, and to a lesser extent, timbre density. In contrast, musical tension had little influence.     

Holographic string encoding

In this article, we apply a special case of holographic representations to letter position coding. We translate different well-known schemes into this format, which uses distributed representations and supports constituent structure. We show that in addition to these brain-like characteristics, performances on a standard benchmark of behavioral effects are improved in the holographic format relative to the standard localist one. This notably occurs because of emerging properties in holographic codes, like transposition and edge effects, for which we give formal demonstrations. Finally, we outline the limits of the approach as well as its possible future extensions.     

What to do? Upgrade!

The contents of what we transmit in colleges and universities as philosophic traditions need upgrading. But so do the methods of transmission.     

Causal Factors of Corruption in Construction Project Management: An Overview

Science and Engineering Ethics - The development of efficient and strategic anti-corruption measures can be better achieved if a deeper understanding and identification of the causes of corruption...     

Moral Luck,Responsibility, and Systems of Tort Liability

Bernard Williams drew our attention to what might be wrong with denying the role of luck in our understanding of agency and responsibility. Susan Wolf and David Enoch, in separate works, have asked us to focus instead on what might be virtuous and valuable in embracing that role, and on how our institutions might assist us in that regard. They claim that the agent who ‘takes’ a responsibility that law or morality do not already assign to them may be displaying a special moral virtue or exercising a distinctive moral power. I raise some objections to Wolf’s and Enoch’s case for that claim, and query some of its purported institutional implications for tort law systems.

     

La Direction des affaires juridiques et des droits des patients de l’AP–HP et la première vague de la pandémie Covid-19

To facilitate the analysis and the management of claims related to the last Covid-19 pandemic, the DAJ of the AP–HP constituted a medical group assisted by lawyers intending to review the scientific knowledge and organizational measures during the first wave of this pandemic. This group brought together medical doctors with both scientific expertise in the main specialties requested during this viral infection and knowledge of repairing bodily damage. Based on the data provided by the hospital dashboards and the collection of hospital procedures for Covid-19 and non-Covid-19 patients, the goal of this group was to assess the level of scientific knowledge and organizational measures respectively at the start of the epidemic, its peak and at the end. During the three periods of this pandemic the main changes observed included a greater selectivity on admissions with increasing consideration on the patient's comorbidity; a continual evolution in drug management and more rigorous isolation measures with interruption of visiting rights. The target was to prevent contamination of the non-infected persons with an obsession to protect healthcare workers. The absence of selection for patients requiring intensive care for compensation of their respiratory failure forced AP–HP to double the number of intensive care beds and to refer some patients in other regions. In a context of unstable scientific knowledge and evolving organizational measures, the collection of these data should facilitate the management of claims related to Covid19 during the first wave of this pandemic and open a prospective study for the next pandemic.