The impact of a lifelong absence of the neuronal nitric oxide synthase (nNOS) in the neuroendocrine stress response was investigated in nNOS knockout (KO) and wild type (WT) mice under basal conditions and in response to forced swimming. In the hypothalamic paraventricular nucleus oxytocin and corticotropin-releasing-hormone mRNA levels did not differ between these genotypes under resting conditions, whereas vasopressin mRNA levels were significantly lower in nNOS KO than in WT animals. Also, in the adrenal glands basal levels of tyrosine hydroxylase protein, the rate-limiting enzyme for catecholamine biosynthesis, and of phenylethanolamine N-methyltransferase, which converts norepinephrine to epinephrine, were significantly reduced in nNOS KO mice. Plasma adrenocorticotropin, corticosterone, norepinephrine and epinephrine levels were similar in the KO and WT genotypes under resting conditions. In response to forced swimming, a similar increase in plasma adrenocorticotropin and corticosterone was observed in KO and WT animals. Stressor exposure triggered also an increased epinephrine release in WT animals, but did not significantly alter plasma epinephrine levels in KO mice. These data suggest that the chronic absence of nNOS reduces the capacity of epinephrine synthesising enzymes in the adrenal gland to respond to acute stressor exposure with an adequate epinephrine release. 相似文献
Are natural language categories represented by instances of the category or by a summary representation? We used an exemplar model and a prototype model, both derived within the framework of the generalized context model (Nosofsky, 1984, 1986), to predict typicality ratings for 12 superordinate natural language concepts. The models were fitted to typicality ratings averaged across participants and to the typicality judgments of individual participants. Both analyses yielded results in favor of the exemplar model. These results suggest that higher-level natural language concepts are represented by their subordinate members, rather than by a summary representation. 相似文献
To investigate contextual influences on gender differences and similarities, we compared adolescents’ endorsement of gender-typed communal/other-focused and agentic/self-focused conflict-management strategies in three relationship contexts: same-gender friends, other-gender friends, and other-gender heterosexual romantic partners. Our 2 Participant Gender (between-subjects) × 3 Relationship Context (within-subjects) mixed factorial design addressed whether findings of prior research (Keener and Strough 2017) with college-aged participants would generalize to adolescents. Participants (n?=?103; 47 male adolescents; 56 female adolescents, 14–17 years-old) from the U.S. South Atlantic and Middle Atlantic regions read nine hypothetical conflict scenarios (three per each relationship context) and rated their likelihood of using gender-typed strategies. Young women and men endorsed communal and agentic strategies significantly more in same- and other-gender friendships than in romantic relationships. Across all three relationship contexts, young women reported using significantly more agentic strategies than young men did. In contrast to previous research on college students (Keener and Strough 2017), the predicted Participant Gender x Relationship Context interaction was not significant in the present study. Our findings suggest that developmental processes such as age differences in gender socialization and lack of experience with romantic relationships might explain why findings from college students did not generalize to adolescents.
Emerging adults are at substantial risk for developing or worsening psychopathology and university students appear to be particularly vulnerable. Interventions targeted at these young adults that can mitigate transdiagnostic causal risk factors or burgeoning mental health problems have the potential to make a large impact. We aimed to develop and pilot test an accessible, single-session, transdiagnostic group intervention with the goals of enhancing emotion regulation skills and reducing risk for mental health problems in graduate students. The intervention included psychoeducation, skills instruction (e.g., mindful emotion awareness, cognitive flexibility, countering emotion-driven behaviors), group discussion, and supervised practice based on content from the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders. The pilot program demonstrated strong feasibility and acceptability. Baseline, 1-month, and 3-month follow-up surveys also suggested benefits for reducing emotional avoidance and suppression, increasing use of cognitive reappraisal, and reducing symptoms of depression and neuroticism. Graduate students have seldom been the beneficiaries of university-based intervention and prevention research. Furthermore, most college and university mental health centers do not have the capacity to provide psychoeducation, preventative, or early intervention services to the many students who need or could benefit from them. Results suggest that future iterations of this intervention could address such barriers to meaningfully supporting emerging adults in graduate school. 相似文献
Most prior research on the tendency for groups to be less cooperative than individuals (the interindividual-intergroup discontinuity effect) has used the Prisoner's Dilemma Game (PDG). Experiment 1 examined the discontinuity effect with 3 additional matrices: Chicken, Leader, and Battle of the Sexes (BOS). Unlike the PDG, these matrices are characterized by correspondence of outcomes. The discontinuity effect was significant for the PDG and Chicken matrices only. With the BOS and Leader matrices, both individuals and groups pursued outcome maximization through coordinated turn taking. Despite the lesser competitiveness, sets of interacting participants in the BOS and Leader conditions did perceive that they were 2 groups. Experiment 2 examined the discontinuity effect in 2 Chicken matrices with varying outcomes associated with mutual competition. Consistent with the doctrine of mutual assured destruction, the discontinuity effect was eliminated for the matrix in which mutual competition was associated with very low outcomes. Although concern for relative in-group standing gave rise to intergroup competition even in the domain of correspondent outcomes, such concern was constrained to the extent that it interfered with outcome maximization. 相似文献
We know less about positive mental imagery than we do about negative mental imagery in depression. This study examined the relationship between depressed mood and the subjective experience of emotion in imagined events; specifically, prospective imagery, and imagery in response to emotionally ambiguous stimuli. One hundred and twenty-six undergraduates completed measures of depression, imagery vividness for future events, and a homograph interpretation task in which they generated images and subsequently rated image pleasantness and vividness. As predicted, compared to low dysphoria, high dysphoria was associated with poorer ability to vividly imagine positive (but not negative) future events. These findings were augmented by the observation that high dysphorics provided lower pleasantness ratings of images generated in response to homographs they interpreted as positive. We suggest that an imbalance in the inability to vividly imagine positive but not negative future events may curtail the ability of high dysphorics to be optimistic. High dysphoric individuals are further disadvantaged: even when they interpret ambiguity positively, the resulting images they generate are associated with less positive affect. Therapeutic strategies that address both such positive-specific imagery biases hold promise for depression treatment innovation. 相似文献
Materialistic strivings have been implicated as a cause of unhappiness. Gratitude, on the other hand – both in its manifestations
as a chronic affective trait and as a more temporary emotional experience – may be a cause of happiness. In the present paper
we review the empirical research on the relationships among materialism, gratitude, and well-being. We present new correlational
data on the gratitude–materialism relationship and propose that gratitude may have the potential to reduce materialistic strivings
and consequently diminish the negative effects of materialistic strivings on psychological well-being. We conclude with some
recommendations for future research on the relationships among gratitude, materialism, and well-being. 相似文献