Enhanced retention in the passive-avoidance task by 5-HT(1A) receptor blockade is not associated with increased activity of the central nucleus of the amygdala

The effect of blockade of 5-HT1A receptors was investigated on (1). retention in a mildly aversive passive-avoidance task, and (2). spontaneous single-unit activity of central nucleus of the amygdala (CeA) neurons, a brain site implicated in modulation of retention. Systemic administration of the selective 5-HT1A antagonist NAN-190 immediately after training markedly-and dose-dependently-facilitated retention in the passive-avoidance task; enhanced retention was time-dependent and was not attributable to variations in wattages of shock received by animals. Systemic administration of NAN-190 had mixed effects on spontaneous single-unit activity of CeA neurons recorded extracellularly in vivo; microiontophoretic application of 5-HT, in contrast, consistently and potently suppressed CeA activity. The present findings-that 5-HT1A receptor blockade by NAN-190 (1). enhances retention in the passive-avoidance task, and (2). does not consistently increase spontaneous neuronal activity of the CeA-provide evidence that a serotonergic system tonically inhibits modulation of retention in the passive-avoidance task through activation of the 5-HT1A receptor subtype at brain sites located outside the CeA.     

Timing variability in circle drawing and tapping: probing the relationship between event and emergent timing

R. Ivry, R. M. Spencer, H. N. Zelaznik, and J. Diedrichsen (2002) have proposed a distinction between timed movements in which a temporal representation is part of the task goal (event timing) and those in which timing properties are emergent. The issue addressed in the present experiment was how timing in conditions conducive to emergent timing becomes established. According to what the authors term the transformation hypothesis, timing initially requires an event-based representation when the temporal goal is defined externally (e.g., by a metronome), but over the first few movement cycles, control processes become established that allow timing to become emergent. Different groups of participants (N = 84) executed either 1 timed interval, 4 timed intervals, or 2 timed intervals separated by a pause. They produced the intervals by either circle drawing, a task associated with emergent timing, or tapping, a task associated with event timing. Analyses of movement variability suggested that similar timing processes were used in the 2 tasks only during the 1st interval. Those results are consistent with the transformation hypothesis and lead to the inference that the transition from event-based control to emergent timing can occur rapidly during continuous movements.     

Coherence of the irrelevant-sound effect: Individual profiles of short-term memory and susceptibility to task-irrelevant materials

We examined individual and developmental differences in the disruptive effects of irrelevant sounds on serial recall of printed lists. In Experiment 1, we examined adults (N = 205) receiving eight-item lists to be recalled. Although their susceptibility to disruption of recall by irrelevant sounds was only slightly related to memory span, regression analyses documented highly reliable individual differences in this susceptibility across speech and tone distractors, even with variance from span level removed. In Experiment 2, we examined adults (n = 64) and 8-year-old children (n = 63) receiving lists of a length equal to a predetermined span and one item shorter (span-1). We again found significant relationships between measures of span and susceptibility to irrelevant sounds, although in only two of the measures. We conclude that some of the cognitive processes helpful in performing a span task may not be beneficial in the presence of irrelevant sounds.     

The effects of outcome expectations and satisfaction on weight loss and maintenance: correlational and experimental analyses--a randomized trial.

This study examines the hypothesis that highly favorable outcome expectations promote weight loss and hinder weight maintenance. To investigate the effects of outcome expectations and satisfaction with treatment outcomes on weight loss, 349 adults were randomly assigned to 1 of 2 weight loss programs that emphasize either (a) an "optimistic" message, focusing exclusively on the positive aspects of weight loss, or (b) a "balanced" message, giving equal time to positive and negative aspects of weight loss. Participants changed their weight loss cognitions in response to the intervention, but there was no significant difference between the intervention treatment groups in short-term or long-term (18-month) weight loss. Independent of treatment message, positive outcome expectations and satisfaction were both associated with weight loss.     

The Factor Structure of Gambling-Related Cognitions in an Undergraduate University Sample

Gambling is relatively common among university students, but few studies examine factors that contribute to gambling behavior in this cohort. Based on evidence that cognitive distortions may play a role in gambling behavior, this study examined the factor structure of gambling-related cognitive distortions using the Gambler’s Beliefs Questionnaire (GBQ; Steenbergh et al., Psychology of Addictive Behaviors, 16:143–149, 2002) in a sample of 393 college undergraduates. Confirmatory factor analysis was used to test a previously reported two-factor model, comprising dimensions of Illusion of Control (IOC) and Luck/Perseverance (L/P). An oblique, but not orthogonal, two-factor model was confirmed but did not provide an incrementally better fit to the data than a one-factor model. However, multiple regression analyses showed that the L/P scale accounted for significant variance in the criterion when controlling for IOC items. This suggests that IOC items provide redundant information and that gambling-related cognitive distortions in this sample can be adequately assessed using solely the L/P factor.

Intentional forgetting is easier after two "shots" than one

Three experiments evaluated whether the magnitude of the list-method directed forgetting effect is strength dependent. Throughout these studies, items were strengthened via operations thought to increase context strength (spaced presentations) or manipulations thought to increment the item strength without affecting the context strength (processing time and processing depth). The assumptions regarding which operations enhance item and context strength were based on the "one-shot" hypothesis of context storage (K. J. Malmberg & R. M. Shiffrin, 2005). The results revealed greater directed forgetting of strong items compared with weak items, but only when strength was varied via spaced presentations (Experiment 3). Equivalent directed forgetting was observed for strong and weak items when strengthening operations increased item strength without affecting the context strength (Experiments 1 and 2). These results supported the context hypothesis of directed forgetting (L. Sahakyan & C. M. Kelley, 2002).     

Recruitment of anterior and posterior structures in lexical-semantic processing: an fMRI study comparing implicit and explicit tasks

Previous studies examining explicit semantic processing have consistently shown activation of the left inferior frontal gyrus (IFG). In contrast, implicit semantic processing tasks have shown activation in posterior areas including the superior temporal gyrus (STG) and the middle temporal gyrus (MTG) with less consistent activation in the IFG. These results raise the question whether the functional role of the IFG is related to those processes needed to make a semantic decision or to processes involved in the extraction and analysis of meaning. This study examined neural activation patterns during a semantic judgment task requiring overt semantic analysis, and then compared these activation patterns to previously obtained results using the same semantically related and unrelated word pairs in a lexical decision task which required only implicit semantic processing (Rissman, J., Eliassen, J. C., & Blumstein, S. E. (2003). An event-related fMRI investigation of implicit semantic priming. Journal of Cognitive Neuroscience, 15, 1160-1175). The behavioral results demonstrated that the tasks were equivalent in difficulty. fMRI results indicated that the IFG and STG bilaterally showed greater activation for semantically unrelated than related word pairs across the two tasks. Comparison of the two task types across conditions revealed greater activation for the semantic judgment task only in the STG bilaterally and not in the IFG. These results suggest that the pre-frontal cortex is recruited similarly in the service of both the lexical decision and semantic judgment tasks. The increased activation in the STG in the semantic judgment task reflects the greater depth of semantic processing required in this task and indicates that the STG is not simply a passive store of lexical-semantic information but is involved in the active retrieval of this information.     

Adolescents’ Endorsement of Communal and Agentic Conflict-Management Strategies with Friends and Romantic Partners

To investigate contextual influences on gender differences and similarities, we compared adolescents’ endorsement of gender-typed communal/other-focused and agentic/self-focused conflict-management strategies in three relationship contexts: same-gender friends, other-gender friends, and other-gender heterosexual romantic partners. Our 2 Participant Gender (between-subjects) × 3 Relationship Context (within-subjects) mixed factorial design addressed whether findings of prior research (Keener and Strough 2017) with college-aged participants would generalize to adolescents. Participants (n?=?103; 47 male adolescents; 56 female adolescents, 14–17 years-old) from the U.S. South Atlantic and Middle Atlantic regions read nine hypothetical conflict scenarios (three per each relationship context) and rated their likelihood of using gender-typed strategies. Young women and men endorsed communal and agentic strategies significantly more in same- and other-gender friendships than in romantic relationships. Across all three relationship contexts, young women reported using significantly more agentic strategies than young men did. In contrast to previous research on college students (Keener and Strough 2017), the predicted Participant Gender x Relationship Context interaction was not significant in the present study. Our findings suggest that developmental processes such as age differences in gender socialization and lack of experience with romantic relationships might explain why findings from college students did not generalize to adolescents.