Gene Concepts and Genethics: Beyond Exceptionalism

The discursive explosion that was provoked by the new genetics could support the impression that the ethical and social problems posed by the new genetics are somehow exceptional in their very nature. According to this view we are faced with special ethical and social problems that create a challenge so fundamental that the special label of genethics is needless to justify. The historical account regarding the evolution of the gene concepts could serve us to highlight the limits of what we know about genes and what we can do with genes. The widespread notion about the exceptionality of genetic knowledge and its applicative possibilities is hardly justifiable and leads to misunderstandings regarding the conceptualization of the ethical and social problems we might face. Following a more realistic interpretation of the role of genes in human life we might avoid a whole set of fictive dilemmas and counterproductive regulatory efforts in bioethics. Bioethical discourse should move from the gene-centered scientific discourse toward the more sophisticated and complex discourses where human development represented as a matter of complex interactions between genomes and environments, between genes, educational factors, nutritional regimes, and other different developmental resources. If a gene is seen as one among the different developmental resources that are shaping a given human trait then both genethics and genetic exceptionalism could hardly be represented as a justified approach in discussing the ethical and social problems of genetics.     

Aspirations,Attainments, and Satisfaction: Life Cycle Differences Between American Women and Men

Aspirations, along with attainments, play an important role in shaping well-being. Early in adult life women are more likely than men to fulfill their material goods and family life aspirations; their satisfaction in these domains is correspondingly higher; and so too is their overall happiness. Material goods aspirations refer here to desires for a number of big-ticket consumer goods, such as a home, car, travel abroad and vacation home. In later life these gender differences turn around. Men come closer than women to fulfilling their material goods and family life aspirations, are more satisfied with their financial situation and family life, and are the happier of the two genders. An important factor underlying the turnaround in fulfillment of aspirations for material goods and family life is probably the shift over the course of the life cycle in the relative proportion of women and men in marital and non-marital unions.     

Associations Between Symptoms of Borderline Personality Disorder,Externalizing Disorders,and Suicide-Related Behaviors

Borderline personality disorder and externalizing disorders are associated with suicide-related behaviors. The present study examined whether symptoms of borderline personality disorder mediate the relationship between externalizing disorders and suicide-related behaviors. Diagnostic interviews were administered to 344 participants (n = 233 women). Results indicated that symptoms of antisocial personality disorder, alcohol use disorders, and drug use disorders each were significantly associated with suicide threats and self-injurious behavior in women and symptoms of antisocial personality disorder were associated with suicide attempts in women. With the exception of the association between symptoms of alcohol dependence and self-injurious behaviors, borderline personality disorder symptoms mediated or partially mediated all associations between externalizing disorders and suicide-related behaviors in women. These results highlight the importance of assessment and treatment of borderline personality disorder symptoms in individuals with externalizing disorders, particularly in the presence of suicide-related behaviors.

Probabilistic Justification and the Regress Problem

We discuss two objections that foundationalists have raised against infinite chains of probabilistic justification. We demonstrate that neither of the objections can be maintained. Presented by Hannes Leitgeb     

The Factor Structure of Gambling-Related Cognitions in an Undergraduate University Sample

Gambling is relatively common among university students, but few studies examine factors that contribute to gambling behavior in this cohort. Based on evidence that cognitive distortions may play a role in gambling behavior, this study examined the factor structure of gambling-related cognitive distortions using the Gambler’s Beliefs Questionnaire (GBQ; Steenbergh et al., Psychology of Addictive Behaviors, 16:143–149, 2002) in a sample of 393 college undergraduates. Confirmatory factor analysis was used to test a previously reported two-factor model, comprising dimensions of Illusion of Control (IOC) and Luck/Perseverance (L/P). An oblique, but not orthogonal, two-factor model was confirmed but did not provide an incrementally better fit to the data than a one-factor model. However, multiple regression analyses showed that the L/P scale accounted for significant variance in the criterion when controlling for IOC items. This suggests that IOC items provide redundant information and that gambling-related cognitive distortions in this sample can be adequately assessed using solely the L/P factor.

The Assumption of Proportional Components when Candecomp is Applied to Symmetric Matrices in the Context of Indscal

The use of Candecomp to fit scalar products in the context of INDSCAL is based on the assumption that the symmetry of the data matrices involved causes the component matrices to be equal when Candecomp converges. Ten Berge and Kiers gave examples where this assumption is violated for Gramian data matrices. These examples are believed to be local minima. It is now shown that, in the single-component case, the assumption can only be violated at saddle points. Chances of Candecomp converging to a saddle point are small but still nonzero.     

Variance Estimation of Nominal-Scale Inter-Rater Reliability with Random Selection of Raters

Most inter-rater reliability studies using nominal scales suggest the existence of two populations of inference: the population of subjects (collection of objects or persons to be rated) and that of raters. Consequently, the sampling variance of the inter-rater reliability coefficient can be seen as a result of the combined effect of the sampling of subjects and raters. However, all inter-rater reliability variance estimators proposed in the literature only account for the subject sampling variability, ignoring the extra sampling variance due to the sampling of raters, even though the latter may be the biggest of the variance components. Such variance estimators make statistical inference possible only to the subject universe. This paper proposes variance estimators that will make it possible to infer to both universes of subjects and raters. The consistency of these variance estimators is proved as well as their validity for confidence interval construction. These results are applicable only to fully crossed designs where each rater must rate each subject. A small Monte Carlo simulation study is presented to demonstrate the accuracy of large-sample approximations on reasonably small samples.     

Arguing ‘for’ the Patient: Informed Consent and Strategic Maneuvering in Doctor–Patient Interaction

As a way to advance integration between traditional readings of the medical encounter and argumentation theory, this article conceptualizes the doctor–patient interaction as a form of info-suasive dialogue. Firstly, the article explores the relevance of argumentation in the medical encounter in connection with the process of informed consent. Secondly, it discloses the risks inherent to a lack of reconciliation of the dialectical and rhetorical components in the delivery of the doctor’s advice, as especially resulting from the less than ideal conditions of the internal states of the doctor and the patient, and the lack of symmetry in their status.