Effects of chronic cocaine administration on spatial learning and hippocampal spine density in two genetically different strains of rats

Lewis and Fischer-344 rats have been proposed as an addiction model because of their differences in addiction behaviour. It has been suggested that drug addiction is related to learning and memory processes and depends on individual genetic background. We have evaluated learning performance using the eight-arm radial maze (RAM) in Lewis and Fischer-344 adult rats undergoing a chronic treatment with cocaine. In order to study whether morphological alterations were involved in the possible changes in learning after chronic cocaine treatment, we counted the spine density in hippocampal CA1 neurons from animals after the RAM protocol. Our results showed that Fischer-344 rats significantly took more time to carry out test acquisition and made a greater number of errors than Lewis animals. Nevertheless, cocaine treatment did not induce changes in learning and memory processes in both strains of rats. These facts indicate that there are genetic differences in spatial learning and memory that are not modified by the chronic treatment with cocaine. Moreover, hippocampal spine density is cocaine-modulated in both strains of rats. In conclusion, cocaine induces similar changes in hippocampal neurons morphology that are not related to genetic differences in spatial learning in the RAM protocol used here.     

Individual characteristics and response to Contingency Management treatment for cocaine addiction

Voucher-based contingency management (CM) research has demonstrated efficacy for treating cocaine addiction, but few studies have examined associations between individual baseline characteristics and response to CM treatments. The aim of this study, involving 50 cocaine outpatients receiving CM for cocaine addiction, was to assess the impact of baseline characteristics on abstinence outcomes after six months of treatment. Patients who were abstinent after six months of treatment accounted for 58% of the sample. Patients with higher scores on the Alcohol area of the EuropASI and patients that were non-abstinent during the first month of treatment were less likely to achieve abstinence. These outcome predictors have implications both for treatment research and for clinical practice. Patients who do not respond early to treatment may need a more intensive intervention, and concomitant problematic alcohol use should be detected and treated. The remaining baseline variables examined were not statistically significant predictors of abstinence. This finding is important for the generalizability of CM across the range of individual characteristics of treatment-seeking cocaine abusers.     

Psychosocial predictors of relapse in cocaine-dependent patients in treatment

Relapses in cocaine abusers in treatment are an important problem. The majority of patients are incapable of sustaining abstinence over any length of time. To identify the factors associated to relapses risk in the cocaine use can be an optimal choice to improve the treatment strategies. The aim of this study was to analyze relapse-risk factors in cocaine-dependent patients on treatment. Participants were 102 patients who had begun outpatient treatment at a public health center in Spain. Some functional areas and cocaine use are evaluated for a period of six months. A structural equations model was used to identify possible predictive variables. The results show that social-family environment and economic-employment situation were associated with greater risk of relapse. Likewise, the social-family environment was related to severity of addiction. It is concluded that the incorporation of family intervention strategies and vocational/employment counseling may help to reduce relapse rates in cocaine addicts receiving treatment.     

Peter Harzem (1930–2008: Bonds and Remembrances in Mexico

The Psychological Record -     

A more complete task-set reconfiguration in random than in predictable task switch

Three experiments are presented that compare the cost found when switching from one task to another in two different conditions. In one of them, the tasks switch in predictable sequences. In the other condition, the tasks alternate at random. A smaller time cost is found in the random-switch condition when enough preparation time is allowed. Such an effect is due to the random-switch cost continuing to decrease with preparation time after the predictable-switch cost has reached an asymptote. Although the relationship between number of repetitions of one task and time cost is different in the random- and the predictable-switch conditions, only the latter shows the presence of an "exogenous" component of cost. The implications of this finding are discussed in relationship with the usual distinction between an endogenous component of switch cost that is affected by preparation time and another exogenous, residual component (e.g., Rogers & Monsell, 1995). It is proposed that a different kind of task-set preparation is at work when tasks alternate at random.     

不可能有精神分析学的危机——1974年拉康访谈录

在1974年的一次访谈中,拉康针对当时人们越来越多地谈到精神分析学的危机问题,明确回答说,弗洛伊德的学说并没有过时,精神分析学也远远没有走到尽头。不过,当时的精神分析学界确实也出现了一些偏离,后辈们并不总是忠实于他们的鼻祖弗洛伊德,精神分析学面临着被教条化、心理学化和平庸化的危险处境。对此,他再次呼吁要回到弗洛伊德去。弗洛伊德认为,精神分析学主要是一门实践学科,是言语的实践,并非行为的治疗。患者的言语,是精神分析的唯一材料。