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161.
Truchan-Tataryn M 《The Journal of medical humanities》2005,26(2-3):159-172
William Faulkner's The Sound and the Fury has become a classic in literary history. Since its publication in 1929, it has sustained critical interest worldwide. Over time, analyses of this work have reflected shifting cultural perspectives of the inscribed human dynamics such as gender, race and sexuality. This paper contends that a similar critical development cannot be detected around the reception of the character of the "idiot," Benjy. Faulknerian scholarship, regardless of its place in time or trend, persists in conflating the dehumanized images of Benjy with the lived experience of disability, thus perpetuating oppressive disability prejudice and limiting the richness of the character's metaphoric potential. Acknowledging this critical lacuna, historicizing and theorizing Benjy's character from a disability perspective could lead to a deeper understanding of human experience. 相似文献
162.
Previous studies on human causal learning (De Houwer & Beckers, 2003; De Houwer, Beckers, & Glautier, 2002) showed that secondary task difficulty (performing an easy vs. a difficult secondary task during the main causal learning task) and ceiling information (outcome occurs with a maximal vs. submaximal intensity) had an influence on forward blocking (i.e., lower causal ratings for cue T when AT+ trials are preceded by A+ trials than when no A+ trials are presented). We extended these studies by also examining self-reports of participants about the reasons behind their causal ratings. Blocking was found only for participants who reported an appropriate blocking inference. Furthermore, secondary task difficulty and ceiling information influenced the number of participants who reported an appropriate blocking inference. These findings point to a major impact of inferential reasoning in human causal learning. 相似文献
163.
De Lillo C Spinozzi G Truppa V Naylor DM 《Journal of comparative psychology (Washington, D.C. : 1983)》2005,119(2):155-165
Results obtained with preschool children (Homo sapiens) were compared with results previously obtained from capuchin monkeys (Cebus apella) in matching-to-sample tasks featuring hierarchical visual stimuli. In Experiment 1, monkeys, in contrast with children, showed an advantage in matching the stimuli on the basis of their local features. These results were replicated in a 2nd experiment in which control trials enabled the authors to rule out that children used spurious cues to solve the matching task. In a 3rd experiment featuring conditions in which the density of the stimuli was manipulated, monkeys' accuracy in the processing of the global shape of the stimuli was negatively affected by the separation of the local elements, whereas children's performance was robust across testing conditions. Children's response latencies revealed a global precedence in the 2nd and 3rd experiments. These results show differences in the processing of hierarchical stimuli by humans and monkeys that emerge early during childhood. 相似文献
164.
This review identified 1275 studies examining cognitive deficits in people with schizophrenia, published between 1990 and
2003. Data from 113 studies (4365 patients and 3429 controls) were combined in a meta-analysis carried out on the five cognitive
domains of IQ, memory, language, executive function, and attention. Studies were excluded where they lacked a suitable control
group or failed to present complete information. In all five cognitive domains, analysis indicated a consistent trend for
patients to perform more poorly than healthy controls, with significant heterogeneity across studies. Sources of heterogeneity
were analyzed and a need to ensure more appropriate composition of patient and control groups and to adopt a more refined
and methodologically correct, hypothesis-driven approach was identified. 相似文献
165.
Much previous research has demonstrated that visual search is typically disrupted by the presence of a unique “singleton”
distractor in the search display. Here we show that attentional capture by an irrelevant color singleton during shape search
critically depends on availability of working memory to the search task: When working memory is loaded in a concurrent yet
unrelated verbal short-term memory task, capture increases. These findings converge with previous demonstrations that increasing
working memory load results in greater distractor interference in Stroop-like tasks (de Fockert, Rees, Frith, & Lavie, 2001;
Lavie, Hirst, de Fockert, & Viding, 2004), which support the hypothesis that working memory provides goal-directed control
of visual selective attention allowing to minimize interference by goal-irrelevant distractors. 相似文献
166.
Cammarota M Bevilaqua LR Rossato JI Ramirez M Medina JH Izquierdo I 《Neurobiology of learning and memory》2005,84(1):25-32
Both the acquisition and the extinction of memories leave short- and long-term mnemonic traces. Here, we show that in male Wistar rats, the short-term memory for a step-down inhibitory avoidance task (IA) is resistant to extinction, and that its expression does not influence retrieval or extinction of long-term memory. It has been known for some time that short- and long-term inhibitory avoidance memory involve separate and parallel processes. Here we show that, instead, short-term extinction of IA long-term memory is the first step towards its long-term extinction, and that this link requires functional NMDA receptors and protein synthesis in the CA1 region of the dorsal hippocampus at the time of the first CS-no US presentation. 相似文献
167.
Animal models are considered essential in research ensuing elucidation of human disease processes and subsequently, testing of potential therapeutic strategies. This is especially true for neurodegenerative disorders, in which the first steps in pathogenesis are often not accessible in human patients. Alzheimer's disease is vastly becoming a major medical and socioeconomic problem in our aging society. Valid animal models for this uniquely human condition should exhibit histopathological, biochemical, cognitive, and behavioral alterations observed in Alzheimer's disease patients. Major progress has been made since the understanding of the genetic basis of Alzheimer's disease and the development and improvement of transgenic mouse models. All present Alzheimer's disease models developed are partial but nevertheless essential in further unraveling the nature and spatial and temporal development of the complex molecular pathology underlying this condition. One of the more recent transgenic attempts to model Alzheimer's disease is the APP23 transgenic mouse. This article describes the development and assessment of this human amyloid precursor protein overexpression model. We summarize histopathological and biochemical, cognitive and behavioral observations made in heterozygous APP23 mice, thereby emphasizing the model's contribution to clarification of neurodegenerative disease mechanisms. In addition, the first therapeutic interventions in the APP23 model are included. 相似文献
168.
The transmission of tool use is a rare event in monkeys. Such an event arose in a group of semi-free-ranging Tonkean macaques (Macaca tonkeana) in which leaning a pole against the parks fence (branch leaning) appeared and spread to several males. This prompted us to test individual and social learning of this behavior in seven young males. In the first experiment, three males learned individually to obtain a food reward using a wooden pole as a climbing tool. They began using the pole to retrieve the reward only when they could alternatively experience acting on the object and reaching the target. In a second experiment, we first tested whether four other subjects could learn branch leaning after having observed a group-mate performing the task. Despite repeated opportunities to observe the demonstrator, they did not learn to use the pole as a tool. Hence we exposed the latter subjects to individual learning trials and they succeeded in the task. Tool use was not transmitted in the experimental situation, which contrasts with observations in the park. We can conclude that the subjects were not able to recognize the target as such. It is possible that they recognized it and learned the task individually when we alternated the opportunity to act upon the object and to reach the reward. This suggests that these macaques could then have associated the action they exercised upon the pole and the use of the pole as a means to reach the reward. 相似文献
169.
Mood-congruent attentional bias in dysphoria: maintained attention to and impaired disengagement from negative information 总被引:1,自引:0,他引:1
Attentional bias to negative information has been proposed to be a cognitive vulnerability factor for the development of depression. In 2 experiments, the authors examined mood-congruent attentional bias in dysphoria. In both experiments, dysphoric and nondysphoric participants performed an attentional task with negative, positive, and neutral word cues preceding a target. Targets appeared either at the same or at the opposite location of the cue. Overall, results indicate that dysphoric participants show maintained attention for negative words at longer stimulus presentations, which is probably caused by impaired attentional disengagement from negative words. Furthermore, nondysphoric participants maintain their attention more strongly to positive words. These results are discussed in relation to recent developments in the pathogenesis and treatment of depression. 相似文献
170.
Knoppers BM 《The American journal of bioethics : AJOB》2005,5(2):33; discussion W3-33; discussion W4