Mood-congruent attentional bias in dysphoria: maintained attention to and impaired disengagement from negative information

Attentional bias to negative information has been proposed to be a cognitive vulnerability factor for the development of depression. In 2 experiments, the authors examined mood-congruent attentional bias in dysphoria. In both experiments, dysphoric and nondysphoric participants performed an attentional task with negative, positive, and neutral word cues preceding a target. Targets appeared either at the same or at the opposite location of the cue. Overall, results indicate that dysphoric participants show maintained attention for negative words at longer stimulus presentations, which is probably caused by impaired attentional disengagement from negative words. Furthermore, nondysphoric participants maintain their attention more strongly to positive words. These results are discussed in relation to recent developments in the pathogenesis and treatment of depression.     

APP23 mice as a model of Alzheimer's disease: an example of a transgenic approach to modeling a CNS disorder

Animal models are considered essential in research ensuing elucidation of human disease processes and subsequently, testing of potential therapeutic strategies. This is especially true for neurodegenerative disorders, in which the first steps in pathogenesis are often not accessible in human patients. Alzheimer's disease is vastly becoming a major medical and socioeconomic problem in our aging society. Valid animal models for this uniquely human condition should exhibit histopathological, biochemical, cognitive, and behavioral alterations observed in Alzheimer's disease patients. Major progress has been made since the understanding of the genetic basis of Alzheimer's disease and the development and improvement of transgenic mouse models. All present Alzheimer's disease models developed are partial but nevertheless essential in further unraveling the nature and spatial and temporal development of the complex molecular pathology underlying this condition. One of the more recent transgenic attempts to model Alzheimer's disease is the APP23 transgenic mouse. This article describes the development and assessment of this human amyloid precursor protein overexpression model. We summarize histopathological and biochemical, cognitive and behavioral observations made in heterozygous APP23 mice, thereby emphasizing the model's contribution to clarification of neurodegenerative disease mechanisms. In addition, the first therapeutic interventions in the APP23 model are included.     

Girls' and boys' developing interests in math and science: do parents matter?

Previous studies (for example, Bregman & Killen, 1999; Eccles, Wigfield, & Schiefele, 1998; Jacobs, 1991;Jacobs & Eccles, 2000) have demonstrated the important role that parents' attitudes play in shaping their children's later self-perceptions and achievement behaviors. Studies indicate that in the math and science arena, parents' perceptions of their children's abilities as well as their own values about math and science are related to their children's later self-perceptions and values for achieving in these domains. The previous work suggests that parents are conveying their attitudes and values about math to their children through their words and actions; however, little research has documented the ways in which parents' beliefs and specific behaviors might promote positive achievement attitudes and behaviors in their children. The goal of the study reported here was to document relations between parents' math and science--promotive behaviors and attitudes and their children's later activity choices, values, and achievement in these subjects.     

Cross-validating the Berlin Affective Word List

We introduce the Berlin Affective Word List (BAWL) in order to provide researchers with a German database containing both emotional valence and imageability ratings for more than 2,200 German words. The BAWL was cross-validated using a forced choice valence decision task in which two distinct valence categories (negative or positive) had to be assigned to a highly controlled selection of 360 words according to varying emotional content (negative, neutral, or positive). The reaction time (RT) results corroborated the valence categories: Words that had been rated as “neutral” in the norms yielded maximum RTs. The BAWL is intended to help researchers create stimulus materials for a wide range of experiments dealing with the emotional processing of words.     

The role of self-efficacy in performing emotion work

This study used a sample of 154 cabin attendants to examine the role of self-efficacy in the performance of emotion work. On the basis of the literature, we hypothesized that self-efficacy would have a moderating influence on the relationship between emotional job demands (i.e., feeling rules and emotionally charged interactions with passengers) and emotional dissonance, and on the relationship between emotional dissonance and well-being (emotional exhaustion and work engagement). In addition, we predicted that emotional dissonance mediates the relationship between emotional job demands and well-being. The results of a series of hierarchical multiple regression analyses generally supported these hypotheses. Results confirmed that emotionally charged interactions with passengers are related to emotional exhaustion and engagement through their influence on emotional dissonance. Furthermore, self-efficacy buffers the relationship between emotional job demands and emotional dissonance, and the relationship between emotional dissonance and work engagement (but not exhaustion).     

Young children's understanding of multiple object identity: appearance, pretense and function

Evidence from theory-of-mind tasks suggests that young children have substantial difficulty thinking about multiple object identity and multiple versions of reality. On the other hand, evidence from children's understanding of pretense indicates that children have little trouble understanding dual object identity and counterfactual scenarios that are involved in pretend play. Two studies reported here show that this competence is not limited to pretend play. Three-year-olds also understand the dual identity involved in unusual functional use (X is being used as Y), even though they have difficulty understanding deceptive appearance (X looks like Y). We suggest that children are able to distinguish extrinsic object properties from intrinsic ones (function vs. category-membership) better than they can distinguish superficial object properties from deep ones (appearance vs. category-membership).     

Damage compounded: disparities, distrust, and disparate impact in end-of-life conflict resolution policies

For a little more than a decade, professional organizations and healthcare institutions have attempted to develop guidelines and policies to deal with seemingly intractable conflicts that arise between clinicians and patients (or their proxies) over appropriate use of aggressive life-sustaining therapies in the face of low expectations of medical benefit. This article suggests that, although such efforts at conflict resolution are commendable on many levels, inadequate attention has been given to their potential negative effects upon particular groups of patients/proxies. Based on the well-documented tendency among many African Americans to prefer more aggressive end-of-life medical interventions, it is proposed that the use of institutional policy to break decision making impasse in cases for which aggressive treatment is deemed "medically inappropriate" will fall disproportionately on that group. Finally, it is suggested that the development and application of institutional conflict-resolution policies should be evaluated in the context of historical and current experiences of marginalization and disempowerment, lest such policies exacerbate that experience.     

Perceived health: a test of incremental validity in relation to smoking outcome expectancies, motivation to smoke and desire to quit smoking

This study examined the role of perceived health in predicting theoretically-relevant aspects of smoking behavior among 161 young adult regular smokers (67 females; mean age = 21.9 years (SD = 7.2), cigarettes per day (M) = 12.2 (SD = 5.7)) recruited from the general community. Consistent with prediction, results indicated that relative to anxiety sensitivity, gender, number of cigarettes smoked per day and nicotine dependence, perceived physical health uniquely and significantly predicted expectancies for negative affect reduction and expectancies that smoking would lead to negative personal consequences. Additionally, perceived health incrementally predicted motivation to smoke to reduce negative affect. In contrast to expectation, perceived health was unrelated to motivation to quit smoking. Results are discussed in relation to the role of perceived health as a cognitive vulnerability factor for specific types of smoking patterns.     

Increased conformity to a fellow deviant as a function of prior deviation

A subject was induced to publically report his opinions on a variety of issues. A group of confederates disagreed with the subject; one confederate agreed with him. Thus, the subject deviated from the majority of the group, but received social support from one other individual. Each subject was then paired with one individual from the previous group, and regardless of his pairing, was subjected to a constant amount of conformity pressure from the confederate on a new set of judgments. Deviant subjects conformed more to the confederate who had previously given them social support than they did to a previous majority member. This increased conformity was found in two studies, (1) females judging physical realities and, (2) males reporting their opinions on attitudinal issues. Ratings taken in the second study demonstrated that the deviant subject felt increased liking for and similarity to the confederate who initially provided him with social support, but comparisons between various experimental groups indicated conformity to a confederate was not completely predictable from the subject's liking for that confederate. Instead, conformity was greatest following an experience of deviation from the majority.     

On the time course of negative priming: Another look

In two experiments, the pattern of persistence of negative priming effects across delay intervals of 500 and 2,500 msec was assessed using a within-subjects, random sequencing of delays. Neill and Valdes (1992; Neill, Valdes, Terry, & Gorfein, 1992) have argued that a within-subject experimental design is required for decay of negative priming to be seen, in contrast to results reported elsewhere (e.g., Tipper, Weaver, Cameron, Brehaut, & Bastedo, 1991) showing stable negative priming effects across delays. In neither experiment was substantial evidence of decay detected, raising questions for the notion that suppression necessarily declines across brief temporal intervals and for the assertion that episodic retrieval is the sole source of negative priming.