A two-year follow-up study of a preventive mental health program for preschoolers

The long-term effects of a preschool intervention program for high-risk experimental children were assessed and compared to a high-risk placebo control group and low-risk normal controls. Seventy first-grade children were involved in this 2-year follow-up. The experimental treatment group was superior to that of the placebo control group at follow-up on the criteria measures of behavioral adjustment and achievement. The low-risk normal control group was significantly different from that of the placebo control groups, but generally not significantly different from that of the experimental groups, suggesting that the intervention had boosted the high-risk experimental treatment children to the point where their performance was comparable to that of children who had not experienced behavioral or learning difficulties.The study was supported by grants from the McGregor Fund and the Eloise and Richard Webber Foundation, and by the Detroit Public Schools, for which the authors express grateful appreciation. A version of this paper was presented at the Annual Meeting of the American Psychological Association, New York, September 1979.     

The treatment of epilepsies with Convulsofin

The testing of Convulsofin carried out in 220 patients at 14 clinics over a period of six months confirms the international experience gained with valproic acid and sodium valproinate. The main field of application of Convulsofin according to the experience gained will again be the treatment of fits in generalised primary epilepsy for which it permits to carry out a monotherapy to a remarkable extent. The favourable effect of the preparation in photosensitivity could be confirmed. Also in generalised secondary epilepsy and in fits of partial epilepsy. Convulsofin is partly effective, so that it can recommended as a co-medication in the treatment of therapy-resistant forms of these epilepsies which are difficult to treat. Decrease in thrombocytes, transient increase in serum transaminases, gastrointestinal disorders, loss of hair and undesired increases in body-weight were the more frequently occurring side-effects.     

EDP (electronic data processing)-oriented special documentation in neurology--extension to a computer epicrisis

The contribution describes a final neurological documentation system for in-patients that permits the computerized print-out of an epicrisis. The computer automatically summarizes the elementary findings and presents them as a number of important neurological syndromes. The structure of the documentation and the experience gained in the course of many years of routine application are described. The system has proved to be basically sound under the conditions existing at a university hospital and a specialized hospital for psychiatry and neurology and has proved applicable for a large proportion of the patients without major restrictions.     

Conditioning of a discriminative drug stimulus: Overshadowing and blocking like procedures

Interactions between a drug discriminative stimulus ( D , 17.5 mg/kg of pentobarbital vs. N , saline) and exteroceptive stimulus conditions (light vs. dark) were examined in a T-maze, shock-escape task using conditioning procedures pertaining to the phenomena of "overshadowing" and "blocking". From an operational point of view, in the "overshadowing" procedure the stimulus compound is introduced from the outset of the training, whereas in the "blocking" procedure the stimuli components are introduced sequentially. When the compound discriminations were established, dose-generalization tests with various doses of pentobarbital (range 5.6–17.5 mg/kg) as well as saline (1 ml/kg) were carried out under both elements (light and dark) of the exteroceptive stimulus dimension. Prior training with drug ( D vs. N ) neutralized the potential influence of the exteroceptive dimension (light vs. dark); conversely training with the exteroceptive stimuli prior to the drug training accentuated the control over behavior by the visual stimuli. Dose-generalization results intermediate to those described above were observed in the group trained to discriminate the stimulus compound ( D plus light vs. N plus dark) from the outset of training. It may therefore be concluded that exteroceptive stimuli can compete with interoceptive drug stimuli for associative strength in the procedure used. Thus, the formal similarities between drug discriminative stimuli and more conventionally studied exteroceptive, sensory signals are furthered by the data.     

Hierarchical factor solution of coding and planning processes: Any new insights?

Hierarchical factor solution was used in the present paper in order to examine if two coding processes, simultaneous and successive, would load on a general 2nd level factor. It was further used to test if the coding processes and a factor representing planful behavior will not share the same general factor, revealing their relative independence as expected from a theoretical model of cognitive functions. Results supported the grouping of the coding tasks within a general factor, as well as the emergence of two general factors, one each for coding and planning. Further correlational evidence supported the relative independence of these two kinds of cognitive processes. These findings were discussed in the context of a general factor of intelligence.     

Processing of threat-related information in rape victims

We investigated selective processing of threat information in persons with posttraumatic stress disorder (PTSD) by using a modified Stroop procedure. Subjects were 15 rape victims with PTSD, 13 rape victims without the disorder, and 16 nontraumatized control subjects. They were asked to name the color of four types of words: specific threat (rape-related) words, general threat (related to physical harm and death) words, neutral words, and nonwords. Rape victims with PTSD evidenced a longer response latency for color naming of rape-related words than for other target-word types. Response latencies of non-PTSD victims and nonvictim control subjects did not differ across word types. Possible mechanisms underlying the selective processing of threat material are considered, and clinical implications are discussed.     

Dealing with labyrinths. General practice and research in psychoanalysis--an evaluation

If psychotherapy research is to yield results relevant for therapeutic practice, it must broaden its receptiveness for the peculiarities of this field and for the methods employed by therapists. The therapist works on-line, while the researcher enjoys the advantage of working off-line. Research in psychotherapy has addressed the world of images and affects, the interactive process, the dependence on models, and the specific manner of information processing characteristic of therapy. The author compares the different ways in which the therapeutic and the empirical settings handle suspicion and error.     

Simultaneous effects and aftereffects of the intensity and success aspect in coping with stresses

Intensity and success of coping processes in achievement-related situations are very often tightly connected. Therefore, the specific empirical status of each of the two aspects is unclear. In the current study a technique is introduced which allows orthogonal variation of both components. 64 subjects were confronted with a simple perceptual-speed task in which objective success rate was held constant by a computer-based adaptive process. Graphic feedback was provided about the objective success rate in relation to one of two different success criteria. For half of the subjects the criterion was above (failure condition) and for the other half it was below (success condition) the adaptively controlled success rate. Intensity, the second between-subjects factor, was manipulated by presenting either a high or a low number of items per time unit. As an additional quasi-experimental factor, the degree of action- vs. state-orientation (Kuhl, 1983) was included. The results showed highly specific effects for both the intensity and the failure/success dimension: High intensity resulted in an increase of electrodermal activity which could be observed throughout a one hour post-stressor phase. The failure/success variation had effects mainly on subjective variables representing appraisal of controllability and produced no after-effects. Especially strong effects on subjective variables could be observed when state-oriented subjects were confronted with both failure and high intensity.     

Hippocampal deafferentation: transplantderived reinnervation and functional recovery

A brief review is provided of the capacity of neural tissue transplants to reinnervate the deafferented hippocampus and repair functional deficits induced by the lesion. The techniques for transplantation of solid pieces of embryonic septum, locus coeruleus or raphe nuclei, or tissue suspensions of embryonic septum, to the adult rat hippocampus are described. Such grafts manifest good long-term survival, provide a good reinnervation of the hippocampus that is histochemically and biochemically appropriate and specific, can establish ultrastructural synaptic contacts with the host, and are electrophysiologically active. Rats with septal grafts manifest recovery of the capacity to learn certain aspects of radial 8-arm maze, T-maze alternation and Morris water-maze tasks. Rats with locus coeruleus grafts manifest an amelioration of lesion-induced hyperactivity. It is concluded that neural tissue transplantation provides a powerful new tool in the study of the functional organization of the hippocampus and its various neurotransmitter-specific afferent systems.     

Functional recovery following brain damage: conceptual frameworks and biological mechanisms

Mammals are well known to manifest recovery over time of many functional impairments induced by brain lesions. A brief reveiw is provided of the different conceptual frameworks within which functional recovery has been examined in the literature, and of different neurobiological mechanisms that have been proposed to account for the phenomenon. We observe that these two levels of analysis have frequently been only loosely related. Finally, a newly identified biological mechanism—compensatory collateral sprouting—is described which appears to be closely related to functional recovery in animals with hippocampal lesions, and this is proposed as a powerful new model within which to investigate further the relationship between the phenomenon of functional recovery and its underlying mechanisms.