The assessment of cortisol using salivary ultrafiltrate

Cortisol can be used to indicate stress level as well as to monitor certain disease states. Although cortisol can be sampled from blood and urine, saliva sampling has decided advantages. Unfortunately, whole saliva contains a number of substances that can metabolize or bind with cortisol, potentially confounding analysis and quantitation. We introduce a semipermeable pouch that accumulates a contaminant-free salivary ultrafiltrate, thereby overcoming a number of the problems encountered with whole saliva. In three studies, we demonstrate accuracy and utility of the device for cortisol determination: (1) in an artificial medium, 60%–77% of the cortisol was recovered in the ultrafiltrate; (2) in vivo, ultrafiltrate cortisol correlated highly with whole-saliva cortisol collected under ideal conditions; and (3) ultrafiltrate cortisol evinced positive relationships with depression and cigarette use, consistent with studies in the literature. We conclude that this device and saliva-filtering technologies in general are useful in applications requiring quantitation of cortisol.     

Aggressivity,inattention, hyperactivity,and impulsivity in boys at high and low risk for substance abuse

Aggressivity, inattention, hyperactivity, and impulsivity are cardinal dimensions of externalizing behavior problems of childhood. They are diagnostic and clinical features of childhood disorders, and are thought to be linked to the subsequent development of adult disorders such as substance abuse (SA). Little is known, however, about the convergent and discriminant validity of these four constructs. We used multiple measures to develop indices of aggressivity, inattention, hyperactivity, and impulsivity in a sample of 10- to 12-year-old boys (N=183) with and without a family history of SA. Data were taken from mother reports, child reports, teacher reports, and laboratory tasks. The study aims were (1) to test the convergent and discriminant validity of aggressivity, inattention, hyperactivity, and impulsivity; (2) to examine whether the data were consistent with a model specifying the four constructs as indicators of one superordinate factor; and (3) to differentiate boys with and without a family history of SA in construct scores. The results supported the convergent and discriminant validity of the four constructs. Although discriminable, the constructs covaried strongly and were consistent with a model specifying them as indicators of a single superordinate factor. Boys with a family history of substance abuse scored higher than control boys on aggressivity, inattention, and impulsivity scores, but the groups did not differ on hyperactivity scores. The results are discussed in terms of the role of childhood behavior problems in vulnerability to SA.This work was supported by the National Institute on Drug Abuse grant No. DA 05605.     

The development of aggression in toddlers: A study of low-income families

The effort by developmental psychopathologists to understand the etiology of antisocial behavior has resulted in several significant findings. First, aggressive behavior is highly stable from early childhood into adolescence and adulthood. Second, parental factors including rearing practices and parental psychopathology, are correlated with childhood behavior problems. It was the aim of the present study to examine the correlates and stability of aggressive behavior in a sample of toddlers from low income families. Eight-nine mother-child dyads (52 boys and 37 girls) were observed in laboratory assessments when the child was 18- and 24-months old. Frequency and pervasiveness of aggression were coded from videotapes. Familial criminality, maternal depressive symptomatology, child noncompliance, and difficult child temperament were examined as contributors to the prediction of aggression in toddlers. Stability of aggression was moderate, especially for aggression occurring in low-stress situations. While there were few sex differences in the frequency and stability of aggression, there were marked differences in the correlates and predictors of aggression. Gender-specific, interactional models of the development of aggression are proposed.This study was supported by grants to Daniel Shaw and Joan Vondra from the following organizations within the University of Pittsburgh: the Mental Health Clinical Research Center for Affective Disorders, the Office of Child Development, the School of Education in conjunction with the Buhl Foundation, and the Faculty of Arts and Sciences. Portions of this paper were presented at the Meeting for the Society for Life History Research, Philadelphia, April 1992. The authors would like to acknowledge the contribution of Julie Alley, Jodi Chusta, and Kevin Cosley for their invaluable assistance in behavioral coding. Special thanks is given to the mothers and children who participated in this research.     

An advocacy intervention program for women with abusive partners: Six-month follow-up

Presented the 6-month follow-up findings of an experimental intervention designed to provide postshelter advocacy services to women with abusive partners. The intervention involved randomly assigning half the research participants to receive the free services of an advocate, 4 to 6 hours per week, for the first 10 weeks postshelter. One hundred forty-one battered women were interviewed about their experiences immediately upon their exit from a domestic violence shelter: 95% of the sample were interviewed 10 weeks thereafter (postintervention), and 93% were successfully tracked and interviewed 6 months later. At the 6-month follow-up, participants in both groups reported increased social support, increased quality of life, less depression, less emotional attachment to their assailants, and an increased sense of personal power. Although women in both groups reported some decrease in physical abuse over time, there were no statistically significant differences between those with and those without advocates, and abuse continued to be a problem for many women. Those who were still involved with their assailants continued to experience higher levels of abuse and had been more economically dependent upon the men prior to entering the shelter. Women who had worked with advocates continued to report being more satisfied with their overall quality of life than did the women in the control group. The authors thank the Editor and anonymous reviewers for their helpful comments. Thanks also to all present and past staff of the Community Advocacy Project, who helped in data collection and analyses. This work was supported by National Institute of Mental Health Grant 1R01 MH 44849.     

Memory impairment and source misattribution in postevent misinformation experiments with short retention intervals

The four experiments reported here provide evidence that (1) misleading postevent suggestions can impair memory for details in a witnessed event and (2) subjects sometimes remember sug-gested details as things seen in the event itself. All four experiments used recall tests in which subjects were warned of the possibility that the postevent information included misleading sug-gestions and were instructed to report both what they witnessed in the event and what was men-tioned in the postevent narrative. Recall of event details was poorer on misled items than on control items, and subjects sometimes misidentified the sources of their recollections. Our re-sults suggest that these findings are not due to guessing or response biases, but rather reflect genuine memory impairment and source monitoring confusions.     

Parents, infants, and day-care teachers: Interrelations and implications for better child care

Many young children are reared today in both family and child-care settings. The relation that exists between these two settings has important implications for child care. Bronfenbrenner's (1979) ecological model is used as a way to view the interrelations among children, families, and child-care programs. Data from a study of infants in day care provide information on the time infants spend in family and day-care contexts, how parents and caregivers view children's behavior in these two settings, and rates of otitis media (ear infections) and other illnesses for these children. Results show that infants spend about twice as many hours per day awake with parents as in day care. Regarding child behaviors, parents and caregivers seem to have similar behaviors they like and dislike, but they each see particular children quite differently with respect to these behaviors. Finally, infants in this sample were diagnosed with illnesses 60% to 70% of the time. Findings are discussed in terms of the ecological model with particular attention given to relations between parents and caregivers.     

Error Types in Ideomotor Apraxia: A Qualitative Analysis

Seventeen brain-damaged subjects with dominant hemisphere pathology and 24 matched control subjects were asked to perform simple familiar gestures under four conditions: (1) verbal command (pantomime), (2) imitation, (3) with the actual object, and (4) verbal command a second time. The subjects subsequently watched a video of an actor performing simple movements and decided whether or not these were performed accurately. The gestural production task was videoed and analyzed for error type. Error type remained consistent over the four task conditions, although subgroups of patients made different types of errors. One group of patients with Ideomotor Apraxia (IMA) made more errors but of the same type as the controls, i.e., movement-related errors and the use of "body part as object" (BPO). The second group made mainly substituted (i.e. unrelated) movements and perseverative errors. The second group of subjects was also poorer at discriminating incorrectly performed movements in the recognition task. BPO errors were commonly made by the control group and they were also chosen as correct in the recognition task. This indicated that use of BPO may reflect a convention in symbolising gestures rather than pathology. The performance of the IMA subjects was discussed in relation to current theories of the mechanisms underlying apraxia.     

Antecedents of information-processing skills in infants: Habituation, novelty responsiveness, and cross-modal transfer

Three skills which characterize cognitive functioning in human infants in the middle of the first year of life—habituation, novelty responsiveness, and cross-modal transfer—predict mental ability in later childhood. Antecedents of each skill at 5 months postnatal were examined in a short-term prospective longitudinal study of infant ability and maternal intelligence and interaction style. Infant perceptuocognitive performance at 2 months, maternal intelligence, and maternal responsiveness at 5 months relate to the expression of the three infant cognitive skills, but in different ways. Variation in infant information-processing abilities can be explained by specific child and maternal factors that are evident soon after birth.