Unpicking the semantic impairment in Alzheimer's disease: qualitative changes with disease severity

Despite a vast literature examining semantic impairment in Alzheimer's disease (AD), consensus regarding the nature of the deficit remains elusive. We re-considered this issue in the context of a framework that assumes semantic cognition can break down in two ways: (1) core semantic representations can degrade or (2) cognitive control mechanisms can become impaired. We hypothesised and confirmed that the nature of semantic impairment in AD changes with disease severity. Patients at mild or severe stages of the disorder exhibited impairment across various semantic tasks but the nature of those deficits differed qualitatively for the two groups. Commensurate with early dysfunction of the cognitive control, temporoparietal-frontal-cingulate network, characteristics of deregulated semantic cognition were exhibited by the mild AD cases. In contrast, the severe AD group reproduced features of additional degradation of core semantic representations. These results suggest that spread of pathology into lateral anterior temporal lobes in later stage AD produces degradation of semantic representations, exacerbating the already deregulated system. Moreover, the dual nature of severe patients' impairment was highlighted by disproportionately poor performance on tasks placing high demand on both conceptual knowledge and control processes--e.g., category fluency.     

Inferring facts from fiction: reading correct and incorrect information affects memory for related information

People can acquire both true and false knowledge about the world from fictional stories. The present study explored whether the benefits and costs of learning about the world from fictional stories extend beyond memory for directly stated pieces of information. Of interest was whether readers would use correct and incorrect story references to make deductive inferences about related information in the story, and then integrate those inferences into their knowledge bases. Participants read stories containing correct, neutral, and misleading references to facts about the world; each reference could be combined with another reference that occurred in a later sentence to make a deductive inference. Later they answered general knowledge questions that tested for these deductive inferences. The results showed that participants generated and retained the deductive inferences regardless of whether the inferences were consistent or inconsistent with world knowledge, and irrespective of whether the references were placed consecutively in the text or separated by many sentences. Readers learn more than what is directly stated in stories; they use references to the real world to make both correct and incorrect inferences that are integrated into their knowledge bases.     

Aging, parafoveal preview, and semantic integration in sentence processing: Testing the cognitive workload of wrap-up

The current study investigated the degree to which semantic-integration processes ("wrap-up") during sentence understanding demand attentional resources by examining the effects of clause and sentence wrap-up on the parafoveal preview benefit (PPB) in younger and older adults. The PPB is defined as facilitation in processing word N + 1, based on information extracted while the eyes are fixated on word N, and is known to be reduced by processing difficulty at word N. Participants read passages in which word N occurred in a sentence-internal, clause-final, or sentence-final position, and a gaze-contingent boundary-change paradigm was used to manipulate the information available in parafoveal vision for word N + 1. Wrap-up effects were found on word N for both younger and older adults. Early-pass measures (first-fixation duration and single-fixation duration) of the PPB on word N + 1 were reduced by clause wrap-up and sentence wrap-up on word N, with similar effects for younger and older adults. However, for intermediate (gaze duration) and later-pass measures (regression-path duration, and selective regression-path duration), sentence wrap-up (but not clause wrap-up) on word N differentially reduced the PPB of word N + 1 for older adults. These findings suggest that wrap-up is demanding and may be less efficient with advancing age, resulting in a greater cognitive processing load for older readers. (PsycINFO Database Record (c) 2012 APA, all rights reserved).     

Brief Exposure to Misinformation Can Lead to Long‐Term False Memories

Do false memories last? And do they last as long as true ones? This study investigated whether experimentally created false memories would persist for an extended period (one and a half years). A large number of subjects (N = 342) participated in a standard three‐stage misinformation procedure (saw the event slides, read the narrations with misinformation, and then took the memory tests). The initial tests showed that misinformation led to a significant amount of false memory. One and a half years later, the participants were tested again. About half of the misinformation false memory persisted, which was the same rate as for true memory. These results strongly suggest that brief exposure to misinformation can lead to long‐term false memory and that the strength of memory trace was similar for true and false memories. Copyright © 2011 John Wiley & Sons, Ltd.     

Quality of Life and Autonomy in Emerging Adults with Early-Onset Neuromuscular Disorders

Emerging adulthood is an important period in the development of one's identity and autonomy. The ways in which identity and autonomy are viewed by emerging adults and how they impact quality of life (QoL) in individuals with early-onset neuromuscular conditions is not yet known. This study focused on understanding and exploring relationships between self-perceptions of emerging adulthood, autonomy, and QoL. Five previously validated measures were incorporated into an online survey and distributed to young adults with early-onset neuromuscular conditions and unaffected controls. Topics explored included individuals' views regarding their overall QoL, disease-specific QoL, components of emerging adulthood, and autonomy. We found that a sense of higher disease impact was associated with a lower Overall General QoL. Additionally, perceptions of key autonomy factors "negativity" and "instability" were uniquely associated with Overall General QoL in the case group as compared to controls, whereas "attitudinal autonomy" (attaining the ability to plan and follow through with goals) was important to this age group regardless of health status. The specific factors of emerging adulthood and autonomy that were significantly correlated with Overall General QoL can be used for developing targeted counseling and interventions to improve QoL for individuals and their families.     

Prior Trauma Exposure for Youth in Treatment Foster Care

Very little research has focused on rates of trauma exposure for youth in treatment foster care (TFC). Available research has utilized record review for assessing exposure, which presents limitations for the range of trauma types examined, as records are predominantly focused on abuse and neglect. The current study examines exposure rates and association with emotional and behavioral outcomes for 229 youth in 46 TFC agencies. The youth in this study had exceptionally high rates of trauma exposure by foster parent report, similar to youth in traditional foster care, with nearly half of the sample exposed to four or more types of traumatic events. A composite child abuse and neglect exposure variable was associated with child and adolescent emotional and behavioral outcomes. Implications for services provided as part of TFC are discussed.     

Associations Between Multiple Types of Stress and Disordered Eating Among Girls and Boys in Middle School

Stress is common during adolescence, yet no known studies have linked particular types of stress (performance, relationship, education, financial, and family) with disordered eating among adolescents in middle school. The present study investigated sex differences in types of stress and how multiple types of stress were associated with girls’ and boys’ body dissatisfaction, dieting behaviors, and bulimic symptoms. We found that girls reported higher levels of stress than boys and that different associations between stress and disordered eating existed for girls and boys. We also examined a path model for both sexes such that stress first led to body dissatisfaction, which then led to dieting and finally bulimic symptoms. Our model was supported for girls with performance, relationship, and family stress driving the process. For boys, all five types of stress were associated with body dissatisfaction, which was linked with dieting; however, the relation between dieting and bulimic symptoms was not significant. Future research and therapy should focus on the unique experiences of each sex in order to gain a better understanding of the processes involved in coping with stress and promoting healthy development.     

MMPI-2-RF characteristics of custody evaluation litigants

The Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) is a 338-item objective self-report measure drawn from the 567 items of the MMPI-2. Although there is a substantial MMPI-2 literature regarding child custody litigants, there has been only one previously published study using MMPI-2-RF data in this population that focused on Validity scales L-r and K-r. The current study evaluated the MMPI-2-RF results of 344 child custody litigants and showed substantial consistency between T-score elevations typically found on MMPI-2 Validity scales L and K, and comparable elevations for MMPI-2-RF validity scales L-r and K-r. Mean T-scores well within normal limits characterized results for clinical scales on both instruments. The RC scale intercorrelation patterns, and alpha coefficient values found for MMPI-2-RF scales in a custody population, were also found to be very similar to those reported for other populations. Directions for future research are presented.     

A Model of Therapist Competencies for the Empirically Supported Interpersonal Psychotherapy for Adolescent Depression

In order to treat adolescent depression, a number of empirically supported treatments (ESTs) have been developed from both the cognitive behavioral therapy (CBT) and interpersonal psychotherapy (IPT-A) frameworks. Research has shown that in order for these treatments to be implemented in routine clinical practice (RCP), effective therapist training must be generated and provided. However, before such training can be developed, a good understanding of the therapist competencies needed to implement these ESTs is required. Sburlati et al. (Clin Child Fam Psychol Rev 14:89–109, 2011) developed a model of therapist competencies for implementing CBT using the well-established Delphi technique. Given that IPT-A differs considerably to CBT, the current study aims to develop a model of therapist competencies for the implementation of IPT-A using a similar procedure as that applied in Sburlati et al. (Clin Child Fam Psychol Rev 14:89–109, 2011). This method involved: (1) identifying and reviewing an empirically supported IPT-A approach, (2) extracting therapist competencies required for the implementation of IPT-A, (3) consulting with a panel of IPT-A experts to generate an overall model of therapist competencies, and (4) validating the overall model with the IPT-A manual author. The resultant model offers an empirically derived set of competencies necessary for effectively treating adolescent depression using IPT-A and has wide implications for the development of therapist training, competence assessment measures, and evidence-based practice guidelines. This model, therefore, provides an empirical framework for the development of dissemination and implementation programs aimed at ensuring that adolescents with depression receive effective care in RCP settings. Key similarities and differences between CBT and IPT-A, and the therapist competencies required for implementing these treatments, are also highlighted throughout this article.