Focused attention deficits in patients with Alzheimer's disease and mild cognitive impairment

Reaction time (RT) tasks take various forms, and can assess psychomotor speed, (i.e., simple reaction time task), and focused attention (i.e., choice reaction time (CRT) task). If cues are provided before stimulus presentation (i.e., cued choice reaction time (CCRT) task), then a cueing effect can also be assessed. A limited number of studies have addressed the nature of focused attention impairments in Alzheimer's disease (AD). Additionally, it is unknown whether similar impairments occur in Mild Cognitive Impairment (MCI). The current study used three RT tasks to address the nature of focused attention impairments in AD and MCI subjects. The results suggest that there were significant CRT and CCRT differences in AD subjects when compared to NECs. Furthermore, slowed RTs were also present in the MCI group, which provides evidence for impaired focussed attention and the inability to benefit from a cue in both the MCI and AD groups. The implications of the impairments related to the MCI group could potentially prove useful in early diagnosis of cognitive impairments in the elderly.     

Phonological dyslexia: a test case for reading models

Following brain damage, skilled readers may encounter more severe problems in reading nonwords than familiar words, a type of deficit referred to as phonological dyslexia. We report on 2 individuals with Alzheimer's disease who show phonological dyslexia. Although highly accurate in reading familiar words aloud (even those with irregular spelling, such as sew), they were quite impaired in nonword reading. Both patients performed well in phonological tasks involving the repetition, identification, and manipulation of phonemes of orally presented words and nonwords. These results challenge the idea, proposed in the context of connectionist and evolutionary theories, that phonological dyslexia originates from a phonological deficit. However, the results are consistent with reading models, such as the dual-route model, that attribute phonological dyslexia to a deficit that selectively affects the reading mechanisms responsible for deriving the sounds of nonwords. According to these models, such a deficit is not necessarily accompanied by a more general phonological impairment.     

Food priming: A therapeutic tool to increase the percentage of meals bought by chronic mental patient

In a motivating ward environment for schizophrenics, three methods of maximizing food as an effective reinforcer were tested. On the basis of pre-treatment measures, patients were classified as (1) “non-chronic meal missers” who served as control patients (Group A), (2) “chronic meal missers” because they had no tokens (Group B), or (3) “chronic meal missers” because they chose not to eat but had tokens (Group C). One of the following three experimental treatments was then administered when a patient missed a meal : (1) visual food priming (observing others eat), (2) oral food priming (sampling one teaspoon of each type of food for that meal), and (3) free meal (being offered a free meal when it was missed). Oral and visual food priming were found to be equally effective in increasing the percentage of meals bought by patients. A post-treatment follow-up for Group B found that this increase was even greater during the follow-up phase. The percentage of meals bought by patients in the free meal condition of Group B decreased during the treatment phase but was significantly above pre-treatment measures during the follow-up phase, suggesting that complete reinforcer sampling may also be an effective technique for increasing the percentage of meals bought.     

TWO CULTURES OF RELIGION AS OBSTACLES TO PEACE

Abstract. There are two contrasting cultures in every religious tradition, the holy war and peaceable garden cultures. Examples are given for Christianity, Judaism, and Islam. Conflict is basic to human existence, stemming from the uniqueness of human individuals and their groups. Churches, instead of helping their societies develop the middle-ground skills of negotiation and mediation, have insisted on a choice between two extreme behaviors: unitive love or destruction of the enemy. In international affairs this has led to the identification of the church with the state in wartime and kept it from claiming the important middle ground of peacemaking. Institutionalized religion can pick up its missed opportunities.     

Quint: An R package for the identification of subgroups of clients who differ in which treatment alternative is best for them

In the analysis of randomized controlled trials (RCTs), treatment effect heterogeneity often occurs, implying differences across (subgroups of) clients in treatment efficacy. This phenomenon is typically referred to as treatment-subgroup interactions. The identification of subgroups of clients, defined in terms of pretreatment characteristics that are involved in a treatment-subgroup interaction, is a methodologically challenging task, especially when many characteristics are available that may interact with treatment and when no comprehensive a priori hypotheses on relevant subgroups are available. A special type of treatment-subgroup interaction occurs if the ranking of treatment alternatives in terms of efficacy differs across subgroups of clients (e.g., for one subgroup treatment A is better than B and for another subgroup treatment B is better than A). These are called qualitative treatment-subgroup interactions and are most important for optimal treatment assignment. The method QUINT (Qualitative INteraction Trees) was recently proposed to induce subgroups involved in such interactions from RCT data. The result of an analysis with QUINT is a binary tree from which treatment assignment criteria can be derived. The implementation of this method, the R package quint, is the topic of this paper. The analysis process is described step-by-step using data from the Breast Cancer Recovery Project, showing the reader all functions included in the package. The output is explained and given a substantive interpretation. Furthermore, an overview is given of the tuning parameters involved in the analysis, along with possible motivational concerns associated with choice alternatives that are available to the user.     

Using Tablets to Collect Data From Young Children

Mobile, touch-screen devices are increasingly ubiquitous in children’s lives. The extensive use of such devices presents an exciting opportunity for data collection. We describe a simple method for creating cross-platform, interactive tablet experiments using open Web-based resources. We illustrate this method by collecting data from 1- to 4-year-old children in a word-recognition paradigm, using 3 different techniques: tablets, eye tracking, and an in-person storybook paradigm. Both accuracy and reaction-time data from the tablet compared favorably with the other methods. Tablets should be considered as a viable method for collecting low-cost, well-controlled developmental data.     

Reliability and validity of IJR Behavior Checklist scores: Number versus pathology level of symptoms

The parent, teacher, and clinician forms of the IJR Behavior Checklist yield four summary scores (checklist total score, pathology weighted total score, mean pathology score, and highest 5 items' mean pathology score). The checklist total score is essentially a symptom count with a double-weighting for frequent/intense occurrence; the other three scores incorporate item pathology weights. All four summary scores were shown to have moderately high validity as measures of the construct child/ adolescent psychopathology: They differentiated between well-adjusted and clinical subsamples at the .001 level. The two scores based entirely on the pathology weights manifested less satisfactory reliability than the two scores reflecting primarily number of symptoms, but surpassed the latter in power to discriminate between psychotic and nonpsychotic patients.     

A cluster-analytically derived typology: Feasible alternative to clinical diagnostic classification of children?

Despite numerous studies of the relationships among symptoms manifested by children and adolescents, there have been few systematic attempts to group individuals on the basis of the syndromes identified. In the course of a treatment evaluation project requiring classification of both child patients and untreated controls, the present study was conducted to determine whether replicable types of children and adolescents could be identified by the cluster analysis of their IJR Behavior Checklist profiles. One clinical sample (N=185) and two mixed clinical and normal subsamples (Ns of 358 and 373) were cluster-analyzed separately. Seven types that replicated across at least two subsamples were identified: (1) High Assets, Flat Symptom Profile; (2) Sociopathic, Academic Problems; (3) Moderate Assets, Egocentric, Incontinent; (4) Insecure, Somaticizing, Underachieving; (5) Aggressive, Overreactive; (6) Schizoid, Withdrawn, Anxious, Bizarre; and (7) Diffuse, Mixed Pathology. The issue posed by the title of the article was explored in the light of the findings.     

Nevertheless,she persisted (in science research): Enhancing women students’ science research motivation and belonging through communal goals

Social Psychology of Education - There is no doubt that connections with other people motivate behavior; yet science is stereotyped as being lonely work devoid of communal connections. Drawing from...     

Intact Procedural Knowledge in Patients with Alzheimer's Disease: Evidence from Golf Putting

Can Alzheimer's disease (AD) patients efficiently learn to perform a complex motor skill when relying on procedural knowledge? To address this question, the authors compared the golf-putting performance of AD patients, older adults, and younger adults in 2 different learning situations: one that promotes high error rates (thus increasing the reliance on declarative knowledge) or one that promotes low error rates (thus increasing the reliance on procedural knowledge). Motor performance was poorer overall for AD patients and older adults relative to younger adults in the high-error condition but equivalent between similar groups in the low-error condition. Also, AD patients in the low-error condition had better performance at the final putting distance relative to those in the high-error condition. This performance facilitation for AD patients likely stems from intact procedural knowledge.