Editorial: Shaping Ethical Futures in Brain-Based and Artificial Intelligence Research

Science and Engineering Ethics -     

The perceptual-mnemonic/feature conjunction model of perirhinal cortex function.

The perirhinal cortex was once thought to be "silent cortex", virtually ignored by researchers interested in the neurobiology of learning and memory. Following studies of brain damage associated with cases of amnesia, perirhinal cortex is now widely regarded as part of a "medial temporal lobe (MTL) memory system". This system is thought to be more or less functionally homogeneous, having a special role in declarative memory, and making little or no contribution to other functions such as perception. In the present article, we summarize an alternative view. First, we propose that components of the putative MTL system such as the hippocampus and perirhinal cortex have distinct and dissociable functions. Second, we provide evidence that the perirhinal cortex has a role in visual discrimination. In addition, we propose a specific role for perirhinal cortex in visual discrimination: the contribution of complex conjunctive representations to the solution of visual discrimination problems with a high degree of "feature ambiguity". These proposals constitute a new view of perirhinal cortex function, one that does not assume strict modularity of function in the occipito-temporal visual stream, but replaces this idea with the notion of a hierarchical representational continuum.     

Cytokine production by spleen cells after social defeat in mice: activation of T cells and reduced inhibition by glucocorticoids

Social disruption (SDR) is an effective model of social stress associated with an enhanced inflammatory reactivity of the immune system. The aim of the present study was to further describe SDR effects on cytokine production by spleen cells, testing selectively monocyte and T cell functions as a result of this stressor. For this purpose, splenocytes from control mice (C) and mice socially stressed for 7 days (SDR) were cultured in the presence of lipopolysaccharide (LPS) or concanavalin A (Con A). Splenocyte proliferation, cytokine production and sensitivity of spleen cells to corticosterone were assessed in vitro. The humoral response to keyhole limpet hemocyanin (KLH) immunization was assessed. SDR induced splenomegaly and enhanced splenocyte basal proliferation. The pro-inflammatory influence of SDR was confirmed by an increased release of interleukin-6 (IL-6) by LPS-stimulated cultures and by a reduced sensitivity of spleen cells to the anti-inflammatory effect of corticosterone. The mechanism increasing cytokine production in response to LPS was cytokine specific, since among inflammatory cytokines, IL-6 but not interferon-gamma (IFN-gamma) was enhanced by stress. In stressed mice, the increase in IL-6 and IFN-gamma and the decrease in IL-10 release in Con A-stimulated cultures indicate that SDR did not modify the Th1/Th2 cytokine balance but globally activated T cells. Plasma anti-KLH antibody levels were similar in both groups. Wounded and non-wounded mice presented similar responses to stress. This study shows that social disruption stress enhances the reactivity of cells from both the acquired and innate immune systems.     

Creating activity schedules using Microsoft Powerpoint

We describe how PowerPoint presentation software can be used to create computer activity schedules to teach individuals with special needs. Presented are the steps involved in creating activity schedules with close-ended and open-ended activities, and for preparing schedules that include photos, sounds, text, and videos that can be used to occasion an individual's engagement in a variety of learning activities.     

Relationship of depression and anxiety to cancer patients' medical decision-making

The purpose of this study was to examine the relation of depression and anxiety to cancer patients' medical decision-making. Participants were 79 rural and urban cancer patients undergoing chemotherapy. The four decisional styles of the Decisional Processing Model were the independent variables. Dependent variables were anxiety and depression, measured by Spielberger's State-Trait Anxiety and the Center for Disease Control Depression Scale, respectively. Consistent with the Decisional Processing Model, analysis suggested that patients make medical decisions by information seeking, information processing, advice following, or ruminating. Decisional style did not vary according to type or stage of cancer, prognosis, time elapsed since initial diagnosis, or whether cancer was initial or recurrent. Decisional style did not systematically vary with depression and anxiety suggesting how a person makes decisions is a stable personality trait. Thus, decision-making may follow a cognitive schema. It is likely that patients' decisional styles help to manage anxiety and depression when confronted with life-threatening illness. Implications for informed consent and patients' involvement in decision-making are discussed.     

Confirmatory factor analysis of the WMS-III in patients with temporal lobe epilepsy

Five competing models specifying the factor structure underlying the Wechsler Memory Scale-Third Edition (D. Wechsler, 1997b) primary subtest scores were evaluated in a sample of patients with intractable temporal lobe epilepsy (N = 254). Models specifying separate immediate and delayed constructs resulted in inadmissible parameter estimates and model specification error. There were negligible goodness-of-fit differences between a 3-factor model of working memory, auditory memory, and visual memory and a nested--more parsimonious--2-factor model of working memory and general memory. The results suggest that specifying a separate visual memory factor provides little advantage for this sample--an unexpected finding in a population with lateralized dysfunction, for which one might have predicted separate auditory and visual memory dimensions.     

Book notes

Apocalyptic Bodies: The Biblical End of the World in Text and Image Tina Pippin, 1999 London, New York: Routledge 160 pp., £14.99 ISBN 0–415–18248–4

The Picture in Question: Mark Tansey and the Ends of Representation Marc C. Taylor, 1999 Chicago, London: University of Chicago Press 144 pp., US$30.00, £23.95 (hb), US$12.00, £9.50 (pb) ISBN 0–226–79128–9 (hb), ISBN 0–226–79129–7

Religion in the Twenty‐first Century Mary Pat Fisher, 1999 London: Routledge 128 pp., £6.99 (pb) ISBN 0–415–21166–2

Religion im Wandel der Kosmologien Religionswissenschaft Vol. 10 Dieter Zeixer, ed., 1999 Frankfurt a.M., Berlin, Berne, New York, Paris, Vienna: Peter Lang 305 pp., £33.00 (pb) ISBN 3–631–33138‐X

Pluralism and the Religions: The Theological and Political Dimensions John D'Arcy May, ed., 1998 London: Cassell 99 pp., £30 (hb), £9.99 (pb) ISBN 0–304–70258–7 (hb), ISBN 0–304–70259–5 (pb)

Sharing Shalom: A Process for Local Interfaith Dialogue between Christians and Jews Philip A. Cunningham & Arthur F. Starr, eds., 1998 New York; Mahwah, NJ: Paulist Press/Stimulus Books 120 pp., US$7.95 (pb) ISBN 0–8091–3835–2

What Price Prejudice? Christian Antisemitism in America Frank E. Eakin, Jr., 1998 New York; Mahwah, NJ: Paulist Press/Stimulus Books 208 pp., US$9.95 (pb) ISBN 0–8091–3822–0

Christian Theology: A Brief Introduction Gareth Jones, 1999 Oxford: Polity Press 178 pp., £45.00 (hb), £14.99 (pb) ISBN 0–7456–1062–5 (hb), ISBN 0–7456–1063–3 (pb)

Holy Smoke. Religion and Roots: A Personal Memoir LiBBY PURVES, 1998 London: Hodder & Stoughton 199 pp., £14.99 (pb) ISBN 0–340–72151–0

Animal Gospel: Christian Faith as though Animals Mattered Andrew Linzey, 1998 London: Hodder & Stoughton 212 pp., £6.99 (pb) ISBN 0–340–62150–8

Vocations in Kerala: A Study on the Changes in the Social Determinants of Vocations to Priesthood and Religious Life in the Catholic Community in Kerala Jose Kuriedath, 1998 Thevara, Kochi, India: Sacred Heart College 144 pp., Rs 50/‐ no ISBN indicated

Jim Bakker: Miscarriage of Justice? James A. Albert, 1997 Chicago; La Salle, Illinois: Open Court Publishing 532 pp., £31.95 (hb), £14.50 (pb) ISBN 0–8126–9369–8 (hb), ISBN 0–8126–9370–1 (pb)

Buddhism and the Mythology of Evil: A Study in Theravada Buddhism Trevor Ling, 1997 Oxford: Oneworld Publications 179 pp., £11.99 (pb) ISBN 1–85168–132–9

Jung on Mythology Robert A. Segal, ed., 1998 London: Routledge 275 pp., £15.99 (pb) ISBN 0–415–19944–1

Islam: A Concise Introduction Neal Robinson, 1999 Richmond, Surrey: Curzon 197 pp., £40.00 (hb), £14.99 (pb) ISBN 0–7007–1103–1 (hb), ISBN 0–7007–1100–7 (pb)

Der Koran: Zugänge und Lesarten Hans Zirker, 1999 Darmstadt: Primus Verlag 230 pp., DM 39.80, SFR 37.00, 6S 291.00 (pb) ISBN 3–89678–121–9

On Faith Nathan Rotenstreich/Paul Mendes‐Flohr, 1998 Chicago, London: University of Chicago Press xii +169 pp., £27.95, US$35.00 (hb), £11.95, US$15.00 (pb) ISBN 0–226–72875–7 (hb), ISBN 0–226–72876–5 (pb)

Hegel's Idea of a Phenomenology of Spirit Michael N. Forster, 1998 Chicago: University of Chicago Press 661 pp., £59.95, US$75 (hb), £23.95, US$30.00 (pb) ISBN 0–226–25740–1 (hb), ISBN 0–226–25742–8 (pb)

Cartesian Questions: Method and Metaphysics Jean‐Luc Marion, 1999 Chicago, London: University of Chicago Press 215 pp., US$25.00, £19.95 (pb) ISBN 0–226–50544–8     

Age-related differences in interhemispheric visuomotor integration measured by the redundant target effect

Presentation of bilateral redundant visual stimuli produces faster reaction times (RT) than presentation of a single unilateral stimulus; an effect known as the redundant target effect (RTE; Miller, 1982), and is a means of testing interhemispheric visuomotor integration (Ouimet, 2009). RTEs that exceed expectations, based on Miller's race model of inequality (RMI), are referred to as "enhanced RTEs" and imply neural coactivation. Paradoxically, enhanced RTEs are observed in cases of corpus callosum disruption. The Hemispheric Coactivation Hypothesis accounts for this paradox by positing that bihemispheric processing occurs to both unilateral and bilateral stimuli in the normal brain, but occurs only with bilateral stimuli in the disconnected brain. Neuroimaging has revealed decreases in the microstructural integrity of the corpus callosum with age (Ota et al., 2006), but research investigating the bilateral RTE in healthy older individuals is lacking. The present study investigated the bilateral RTE in healthy younger and healthy older adults using simple RT and choice RT tasks. Our prediction that older individuals would show significantly larger RTEs than younger individuals was found to be true for both tasks. Tests of the RMI produced little evidence for coactivation. The crossed-uncrossed difference, generally used as a means of testing visuomotor interhemispheric transfer, was also investigated, but no age effects were found. The observation of greater RTE in age is congruent with the Hemispheric Coactivation hypothesis (Miller, 2004) in which callosal disconnection is associated with increased RTE.