Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes

The administration of the ryanodine receptor (RyR) agonist 4-Cmc (0.003-9 nmol per mouse intracerebroventricularly [i.c.v.]) ameliorated memory functions, whereas the RyR antagonist ryanodine (0.0001-1 nmol per mouse i.c.v.) induced amnesia in the mouse passive avoidance test. The role of the type 1, 2, and 3 RyR isoforms in memory processes was then evaluated by inhibiting the expression of the three RyR proteins in the mouse brain. A selective knockdown of the RyR isoforms was obtained by the i.c.v. administration of antisense oligonucleotides (aODNs) complementary to the sequence of RyR1, RyR2 and RyR3 proteins, as demonstrated by immunoblotting experiments. RyR1 (5-9 nmol per mouse i.c.v.) knockdown mice did not show any memory dysfunction. Conversely, RyR2 (1-7 nmol per mouse i.c.v.) and RyR3 (1-7 nmol per mouse i.c.v.) knockdown animals showed an impairment of memory processes. This detrimental effect was temporary and reversible, disappearing 7 d after the end of the aODN treatment. At the highest effective doses, none of the compounds used impaired motor coordination, as revealed by the rota rod test, nor modified spontaneous mobility and inspection activity, as revealed by the hole-board test. In conclusion, the lack of any involvement of cerebral RyR1 was demonstrated. These findings also showed the involvement of type 2 and type 3 RyR in the modulation of memory functions identifying these cerebral RyR isoforms as critical targets underlying memory processes.     

The cost of thinking about false beliefs: evidence from adults' performance on a non-inferential theory of mind task

Much of what we know about other people's beliefs comes non-inferentially from what people tell us. Developmental research suggests that 3-year-olds have difficulty processing such information: they suffer interference from their own knowledge of reality when told about someone's false belief (e.g., [Wellman, H. M., & Bartsch, K. (1988). Young children's reasoning about beliefs. Cognition, 30, 239-277.]). The current studies examined for the first time whether similar interference occurs in adult participants. In two experiments participants read sentences describing the real colour of an object and a man's false belief about the colour of the object, then judged the accuracy of a picture probe depicting either reality or the man's belief. Processing costs for picture probes depicting reality were consistently greater in this false belief condition than in a matched control condition in which the sentences described the real colour of one object and a man's unrelated belief about the colour of another object. A similar pattern was observed for picture probes depicting the man's belief in most cases. Processing costs were not sensitive to the time available for encoding the information presented in the sentences: costs were observed when participants read the sentences at their own pace (Experiment 1) or at a faster or a slower pace (Experiment 2). This suggests that adults' difficulty was not with encoding information about reality and a conflicting false belief, but with holding this information in mind and using it to inform a subsequent judgement.     

Reducing Disparities in Cancer Screening and Prevention through Community‐Based Participatory Research Partnerships with Local Libraries: A Comprehensive Dynamic Trial

Reduction of cancer‐related disparities requires strategies that link medically underserved communities to preventive care. In this community‐based participatory research project, a public library system brought together stakeholders to plan and undertake programs to address cancer screening and risk behavior. This study was implemented over 48 months in 20 large urban neighborhoods, selected to reach diverse communities disconnected from care. In each neighborhood, Cancer Action Councils were organized to conduct a comprehensive dynamic trial, an iterative process of program planning, implementation and evaluation. This process was phased into neighborhoods in random, stepped‐wedge sequence. Population‐level outcomes included self‐reported screening adherence and smoking cessation, based on street intercept interviews. Event‐history regressions (n = 9374) demonstrated that adherence outcomes were associated with program implementation, as were mediators such as awareness of screening programs and cancer information seeking. Findings varied by ethnicity, and were strongest among respondents born outside the U.S. or least engaged in care. This intervention impacted health behavior in diverse, underserved and vulnerable neighborhoods. It has been sustained as a routine library system program for several years after conclusion of grant support. In sum, participatory research with the public library system offers a flexible, scalable approach to reduce cancer health disparities.     

Parenting Assessed by Observation versus Parent-report: Moderation by Parent Distress and Family Socioeconomic Status

Assessment of parenting frequently relies on parent self-report despite well-documented discrepancies between this methodology and observational measures. In the current study, we investigated patterns of disagreement between self-reported and observational measures of positive parenting and negative parenting with 102 dyads of parents and 4–6 year-old children. Specifically, we tested whether differences in parent distress and family socioeconomic status (SES) moderated the association between self-reported and observed parenting. Results showed significant interactions with less agreement between self-report and observational measures among parents reporting higher levels of distress and among families from lower SES backgrounds. Effects were more pronounced in models of negative parenting than those of positive parenting. Findings suggest that two factors relevant to parenting quality, emotional distress and SES, predict meaningful differences in manner of parent-report relative to observational measures. We discuss implications for the extant literature and for future efforts regarding effective and efficient parenting measurement.     

Working memory in healthy aging and in Parkinson’s disease: evidence of interference effects

Focusing on relevant information while suppressing the irrelevant one are critical abilities for different cognitive processes. However, their functioning has been scarcely investigated in the working memory (WM) domain, in both healthy and pathological conditions. The present research aimed to study these abilities in aging and Parkinson’s disease (PD), testing three groups of healthy participants (young, older and elderly) and one of PD patients, employing a new experimental paradigm. Results showed that the transient storing of irrelevant information in WM causes substantial interference effects, which were remarkable in elderly individuals on both response latency and accuracy. Interestingly, PD patients responded faster and were equally accurate compared to a matched control group. Taken together, findings confirm the existence of similar mechanisms for orienting attention inwards to WM contents or outwards to perceptual stimuli, and suggest the suitability of our task to assess WM functioning in both healthy aging and PD.     

Conceptions of Plagiarism and Problems in Academic Writing in a Changing Landscape of External Regulation

The aim of this study was to investigate the consequences of the use of text-matching software on teachers’ and students’ conceptions of plagiarism and problems in academic writing. An electronic questionnaire included scale items, structured questions, and open-ended questions. The respondents were 85 teachers and 506 students in a large Finnish university. Methods of analysis included exploratory factor analysis, t-test, and inductive content analysis. Both teachers and students reported increased awareness of plagiarism and improvements in writing habits, as well as concerns and limitations related to the system. The results suggest that teachers are inclined to think of plagiarism as part of a learning process rather an issue of morality, which may have consequences for how they understand the role of text matching. The introduction of text-matching software has supported teachers’ work, but at the same time teachers emphasized their own responsibility in detecting problems in student writing. The survey provides a limited sample of “Case Finland,” where implementation of text-matching software nationwide has been remarkably rapid; it offers a glimpse into one institution’s implementation of a newly introduced policy for mandatory plagiarism detection.     

A Developmental–Behavioral Approach to Outpatient Psychotherapy with Children with Autism Spectrum Disorders

Over the course of development, children with autism spectrum disorders (ASDs) may present with an array of behavioral symptoms in addition to the primary impairments in language, socialization, and repetitive/restricted interests. These developmental challenges allow outpatient psychotherapists the opportunity to provide helpful clinical services to children and adolescents with ASDs. This can be best accomplished by combining behavioral strategies that are typically effective with children with ASDs with evidence-based approaches helpful for other psychiatric conditions. Four case examples are provided that review how to use both ASDs and general child clinical interventions with children with ASDs and their families.     

A Grounded Theory Study of Spirituality: Using Personal Narratives Suggested by Spiritual Images

This study expanded on traditional concepts of spirituality through an analysis of narratives derived from images with spiritual content. Twenty-five participants were selected based on their being actively involved in spiritual practices. They were requested to tell TAT-type stories to a series of twelve images that revolved around spiritual themes. The resulting 300 stories were coded according to Grounded Theory procedures. A theory of spirituality emerged that centered upon the expression of suffering and the expectation of it being relieved. Results suggest that the personal spiritual process is one that expects and seeks transformation of the suffering through a connection with another, a connection with the transcendent, acquiring wisdom, or transforming the internal state.