Enhancing theory of mind in behavioural variant frontotemporal dementia with transcranial direct current stimulation

Behavioural variant frontotemporal dementia (bvFTD) is a form of frontotemporal degeneration characterized by early changes in personality, emotional blunting, and/or loss of empathy. Recent research has highlighted that these features may be at least partially explained by impairments in the theory of mind (ToM; i.e., the ability to understand and predict other people’s behaviour by attributing independent mental states to them). The aim of this randomized, double-blind, placebo-controlled study was to test the hypothesis that transcranial direct current stimulation (tDCS) over the medial frontal cortex (MFC) selectively enhances communicative intention processing, a specific ToM ability. Using a single-session online design, we administered a ToM task that measures the ability to represent other people’s private and communicative intentions during active or sham tDCS to 16 bvFTD patients. To assess the impact of dementia on performance on the ToM task, we included 16 age-matched healthy volunteers who were asked to perform the entire experimental ToM task. BvFTD is characterized by an impairment in the comprehension of both communicative and private intentions relative to a healthy control group and by a disproportional impairment in communicative intention compared with private intention processing. Significant and selective accuracy improvement in the comprehension of communicative intentions after active stimulation was observed in patients with bvFTD. This is the first study that analyses ToM ability in patients with bvFTD using tDCS stimulation. Our findings could potentially contribute to the development of an effective, noninvasive brain stimulation treatment of ToM impairments in patients with bvFTD.     

Family Allocentrism and Adolescent Depressive Symptoms: The Role of Self-Identity Style

Recent research has found that a strong family allocentrism relates to reduced adolescent depressive symptoms. Besides providing continuous support for this relation, this research extended the scope by exploring whether there was a U-shaped association between family allocentrism and depressive symptoms and testing the mediation effect of identity style among Italian adolescents (N?=?387, 183 boys, 204 girls, M_age?=?16.38 years). Result of hierarchical regression model showed that the association between family allocentrism and depressive symptoms was linear rather than U-shaped. More importantly, this linear relation was mediated by normative and diffuse-avoidant style. In sum, the current findings suggest that adolescents who are allocentric toward family tend to follow family members’ expectations to establish self-identity and deal with identity issues more proactively, and thus they are less likely to experience depressive symptoms. Moreover, there is no significant evidence that too much family allocentrism would lead to elevated depressive symptoms.     

Giving Voice to Patients: Developing a Discussion Method to Involve Patients in Translational Research

Biomedical research policy in recent years has often tried to make such research more ‘translational’, aiming to facilitate the transfer of insights from research and development (R&D) to health care for the benefit of future users. Involving patients in deliberations about and design of biomedical research may increase the quality of R&D and of resulting innovations and thus contribute to translation. However, patient involvement in biomedical research is not an easy feat. This paper discusses the development of a method for involving patients in (translational) biomedical research aiming to address its main challenges.After reviewing the potential challenges of patient involvement, we formulate three requirements for any method to meaningfully involve patients in (translational) biomedical research. It should enable patients (1) to put forward their experiential knowledge, (2) to develop a rich view of what an envisioned innovation might look like and do, and (3) to connect their experiential knowledge with the envisioned innovation. We then describe how we developed the card-based discussion method ‘Voice of patients’, and discuss to what extent the method, when used in four focus groups, satisfied these requirements. We conclude that the method is quite successful in mobilising patients’ experiential knowledge, in stimulating their imaginaries of the innovation under discussion and to some extent also in connecting these two. More work is needed to translate patients’ considerations into recommendations relevant to researchers’ activities. It also seems wise to broaden the audience for patients’ considerations to other actors working on a specific innovation.     

Changes in research on Judaism in the Hellenistic and early Roman periods

This article offers an overview of what every theologian and scholar of religion should know about changes in biblical studies that have taken place concerning the past depreciation of Second Temple Judaism, the use of newly discovered sources and their implications, as well as integrative approaches to top-down (reflected beliefs, prescribed practices, textual sources) and bottom-up (intuitive beliefs, lived practices, material culture) processes. Changes in the field lead to the re-writing of the history of the Bible and of Judaean society in the Greco-Roman context. By means of this co-authored research article, we wish to demonstrate the benefit of, as well as the need for, interdisciplinary work in the study of antiquity.     

Brightness for different surround conditions: the effect of transient glare

We measured the effect of a transient glare source on t heperceived brightness of astandard luminance (L(STD)) patch (0.5 cd/m2) as a function of the surround luminance (Ls). In the experiment, both increment and decrement stimuli were dependent on the value of the Ls (0.01, 0.2, 0.4, 0.6, 0.8, 1.0, 1.5, or 2.0 cd/m2). We adopted a magnitude comparison paradigm using constant stimuli to determine the test matching luminance (L(M)). When L(S) was lower than the luminance of the patch, which corresponds to increments, LM was lower than L(STD), and this effect was highest for the lowest L(S). There was a small but noticeable cusp as increments shifted to decrements. As L(S) increased further (i.e., as the decrement grew), L(M) flattened out below L(STF). The overall pattern of results could be interpreted in terms of the concept of contrast brightness, with consideration of the intrinsic differences in brightness evaluations between decrements and increments.     

Working Memory Capacity and the Development of Quantitative Central Conceptual Structures

Abstract

This article reconsiders Case’s theory of central conceptual structures (CCS), examining the relation between working memory and the acquisition of quantitative CCS. The lead hypothesis is that the development of working memory capacity shapes the development of quantitative concepts (whole and rational numbers). Study I, with 779 children from preschool to grade 5, validated a measure of the whole number CCS and found that children’s understanding of whole number advances by one developmental level per additional unit of working memory capacity. Study II, with 92 sixth- and seventh-graders, found that a test of the rational number CCS was predicted by working memory capacity and, to a lesser extent, by intrusion errors in the listening span. We also identified 2 subsets of items that demand a capacity of 4 or 5 units, respectively. Overall, the results support Case’s CCS theory and clarify the role of working memory in the acquisition of numerical concepts. The relevance of these results in relation to the current debate is discussed, with extensive connections to other current theories of whole or rational number comprehension.     

The recognition of mental states from dynamic and static facial expressions

The ability to recognize mental states from facial expressions is essential for effective social interaction. However, previous investigations of mental state recognition have used only static faces so the benefit of dynamic information for recognizing mental states remains to be determined. Experiment 1 found that dynamic faces produced higher levels of recognition accuracy than static faces, suggesting that the additional information contained within dynamic faces can facilitate mental state recognition. Experiment 2 explored the facial regions that are important for providing dynamic information in mental state displays. This involved using a new technique to freeze motion in a particular facial region (eyes, nose, mouth) so that this region was static while the remainder of the face was naturally moving. Findings showed that dynamic information in the eyes and the mouth was important and the region of influence depended on the mental state. Processes involved in mental state recognition are discussed.     

Task dependent modulation of exogenous attention: Effects of target duration and intervening events

Inhibition of return (IOR) consists of slower reaction times in response to stimuli appearing at previously attended or inspected locations. The exact mechanisms underlying the effect have not yet been determined. In the present work, we manipulated two variables, target duration and intervening event (fixation cue between cue and target), through which we modulated the IOR effect as a function of task. When the target was presented until response, the presence of an intervening event made the cueing effect more negative in all tasks, although facilitation in the absence of an intervening event was only observed in discrimination and go–no-go tasks. When the target duration was 50 ms, the effect of the intervening event on cueing was also only observed for the discrimination and go–no-go tasks. Target duration had no effect at all in the discrimination task. Possible mechanisms for these modulations (detection cost and spatial selection benefit, both of which are based on cue–target integration processes) are discussed.     

Potential Projective Material on the Rorschach: Comparing Comprehensive System Protocols to Their Modeled R-Optimized Administration Counterparts

Exner (1989 Exner, J. E. (1989). Searching for projection in the Rorschach. Journal of Personality Assessment, 53, 520–536.[Taylor &; Francis Online], [Web of Science ®] , [Google Scholar]) and Weiner (2003 Weiner, I. B. (2003). Principles of Rorschach interpretation (2nd ed.). Mahwah, NJ: Erlbaum. [Google Scholar]) identified 3 types of Rorschach codes that are most likely to contain personally relevant projective material: Distortions, Movement, and Embellishments. We examine how often these types of codes occur in normative data and whether their frequency changes for the 1st, 2nd, 3rd, 4th, or last response to a card. We also examine the impact on these variables of the Rorschach Performance Assessment System's (R–PAS) statistical modeling procedures that convert the distribution of responses (R) from Comprehensive System (CS) administered protocols to match the distribution of R found in protocols obtained using R-optimized administration guidelines. In 2 normative reference databases, the results indicated that about 40% of responses (M = 39.25) have 1 type of code, 15% have 2 types, and 1.5% have all 3 types, with frequencies not changing by response number. In addition, there were no mean differences in the original CS and R-optimized modeled records (M Cohen's d = –0.04 in both databases). When considered alongside findings showing minimal differences between the protocols of people randomly assigned to CS or R-optimized administration, the data suggest R-optimized administration should not alter the extent to which potential projective material is present in a Rorschach protocol.