Stimulus aspects of aversive controls: the effects of response contingent shock

A tone ending with electrical shock was periodically presented to pigeons while they pecked a key for food. Pairs of birds were run simultaneously under a yoked program which insured that both birds received the same number and temporal distribution of shocks. For one of the birds, shock was always initiated by a peck; for the other, shock was unavoidable. Both procedures led to reduced rates of pecking in the presence of the tone, and gradients of stimulus generalization were obtained. But the effects of response contingent shock extinguished more rapidly than the effects of unavoidable shock. In general, birds exposed to unavoidable shock tended to respond at intermediate rates throughout tone, whereas those exposed to response contingent shock ceased to peck for part or all of the tone period.     

Stress-induced breakdown of an appetitive discrimination

Rats trained to discriminate between S^D and S^Δ for food reinforcement showed marked impairments in this discrimination when strong, unavoidable shocks occurred at the termination of a third stimulus. The predominant feature of this impairment was a supernormal rate of unreinforced (S^Δ) behavior. Shocks delivered without exteroceptive warning also led to a discriminative breakdown. The effect was a direct function of shock intensity. When behavior was strongly suppressed in the third stimulus by response-correlated shock (“punishment”), instead of unavoidable shock, breakdowns were only temporary; as soon as responding recovered from its overall suppression, discriminative performance returned to normal. The discriminative deterioration may be interpreted as an emotional by-product of frequent aversive stimulation, but accidental contingencies could also have played a role.     

Development of behavioral compensation to the effects of scopolamine during fixed-interval reinforcement

Rats were injected with scopolamine before every daily session of water reinforcement on a fixed-interval (FI) schedule. Initially the drug decreased the rate of responding. Control injections of scopolamine following each session did not. Over 119 sessions, the typical FI performance developed more slowly in the animals drugged before the sessions. Their rates of responding increased from session to session, to a level slightly greater than that of the animals drugged after the sessions. Their rates did not increase. The effects of injections before the session were not duplicated by increasing the deprivation of animals drugged after the session.     

STUDIES IN THE PSYCHOLOGICAL EFFECTS OF A NEW DRUG (DIETHYLPROPION): Subjective effects in the natural environment

Two doses diethylpropion, one dose pipradrol, one dose amobarbital and placebo were administered to 116 subjects, who rated their state on twenty variables. The variables were intercorrelated under pipradrol and pentymal. The correlation matrices were subjected to factor analysis. Four factors were found in both studies: Happiness, Alertness, Relaxation, and Flight of thoughts. There is some agreement between the two factor analyses. There were few significant effects of the drugs on factor scores, but the structure is quite unambiguous: pipradrol and diethylpropion are stimulating, and amobarbital tranquilizing.