Placebo in the investigation of psychotropic drugs,especially antidepressants

The paper presents major ethical, legal and methodological problems related to the use of placebo in mental disorders, especially in depression. It is pointed out that although authoritative groups of experts and numerous publications in the field of psychopharmacology indicate advisability of the double blind design with placebo in clinical trials of antidepressants, in recent years there have been more and more voices questioning legitimacy of this method. Objections of an ethical nature are raised, and reliability of this approach is put into doubt from the methodological viewpoint. These issues are discussed in more detail in the paper. Available alternative solutions should be implemented in psychotropic drug studies. The author shares these objections and doubts of an ethical nature, and believes that the placebo procedure is not a necessity in clinical trials of antidepressants. An earlier version of this paper was presented at an international conference, “Placebo: Its Action and Place in Health Research Today,” held in Warsaw, Poland on 12–13 April, 2003.     

Counterfactual thinking and posttraumatic stress reactions

Preoccupation with alternative outcomes (counterfactual thinking) is a central component of the ruminations of trauma victims. The questions investigated were whether such thinking should be distinguished from general rumination and whether elements of counterfactual thinking might relate to the process of adjustment. A sample of assault victims was interviewed. They completed a battery of self-report scales and thought-listing procedures. Frequency of counterfactual thinking was closely associated with continuing levels of posttraumatic distress. However, high availability of counterfactuals (as indexed by verbal fluency) was related to potentially adaptive outcomes, such as the generation of behavioral plans. In addition, as expected, levels of different aspects of counterfactual thinking were moderated by metacognitive control strategies as a function of time since the trauma.     

The Intersection of Perceptions and Experiences of Bullying by Race and Ethnicity among Middle School Students in the United States

Little is known about how ethnic identity influences bullying. Using a racially diverse sample, we examine how within-race perceptions match experiences. We utilize bivariate probit regression to examine the correlation between actual and perceived victimization and bullying experiences. Results suggest no differences in victimization by ethnicity but perceived victimization differed across groups. Perceived and actual bullying differed across all groups. School climate acted as a protective factor against bullying and victimization, but school diversity increased the likelihood of bullying by whites and Latinos. These findings shed light on the importance of ethnic identity in understanding the etiology of bullying.     

Marked referential communicative behaviours,but no differentiation of the “knowledge state” of humans in untrained pet dogs versus 1-year-old infants

The study examines whether untrained dogs and infants take their caregiver’s visual experience into account when communicating with them. Fifteen adult dogs and 15 one-year-old infants were brought into play with their caregivers with one of their own toys. The caregiver gave the toy to the experimenter, who, in different conditions, placed it either above or under one of two containers, with both the infant or dog and the caregiver witnessing the positioning; in a third condition, the caregiver left the room before the toy was placed under one of the two containers and later returned. Afterwards, for each condition, the caregiver asked the participant to indicate the location of the toy. Neither dogs nor infants—untrained to the use of the partner’s knowledge state—showed much difference of behaviour between the three conditions. However, dogs showed more persistence for most behaviours (gaze at the owner, gaze at the toy and gaze alternation) and conditions, suggesting that the situation made more demands on dogs’ communicative behaviours than on those of infants. When all deictic behaviours of infants (arm points towards the toy and gaze at the toy) were taken into account, dogs and infants did not differ. Phylogeny, early experience and ontogeny may all play a role in the ways that both species communicate with adult humans.     

Józef M. Bocheński and the categorial reconstruction of concepts in the Lvov–Warsaw School

Studies in East European Thought - In this article, Józef M. Bocheński is presented as a representative of the methodological tendencies of the Lvov–Warsaw School (LWS). Special...     

Attentional bias in post-traumatic stress disorder diminishes after symptom amelioration

Background

Avoidance and hypervigilance to reminders of a traumatic event are among the main characteristics of post-traumatic stress disorder (PTSD). Attentional bias toward aversive cues in PTSD has been hypothesized as being part of the dysfunction causing etiology and maintenance of PTSD. The aim of the present study was to investigate the cognitive strategy underlying attentional bias in PTSD and whether normal cognitive processing is restored after a treatment suppressing core PTSD symptoms.

Methods

Nineteen healthy controls were matched for age, sex and education to 19 PTSD patients. We used the emotional stroop and detection of target tasks, before and after an average of 4.1 sessions of eye movement desensitization and reprocessing (EMDR) therapy.

Results

We found that on both tasks, patients were slower than controls in responding in the presence of emotionally negative words compared to neutral ones. After symptoms removal, patients no longer had attentional bias, and responded similarly to controls.

Conclusion

These results support the existence of an attentional bias in PTSD patients due to a disengagement difficulty. There was also preliminary evidence that the disengagement was linked to PTSD symptomatology. It should be further explored whether attentional bias and PTSD involve common brain mechanisms.     

Développement de la précision temporo-motrice et cadences spontanées de jeunes enfants

Fifty children (six to ten years old) were asked to tap a flat surface as regularly as possible with their finger at different semi-spontaneous tempi. Their chosen tapping speed was estimated by each sequence's mean inter-tap interval. The range of chosen speeds widens with age. The just tenable difference (JTD) between inter-tap intervals is proportional to their reference, the mean. The motor-timing precision, estimated through the standard-deviation/mean ratio, clearly improves with age. Children are more precise at faster tempi, not around their “normal” tempo as adults. Our simple semi-spontaneous finger-tapping task could be applied to the clinical evaluation of age-dependent explicit and implicit timing components in motor performance.     

Finding words in a language that allows words without vowels

Across many languages from unrelated families, spoken-word recognition is subject to a constraint whereby potential word candidates must contain a vowel. This constraint minimizes competition from embedded words (e.g., in English, disfavoring win in twin because t cannot be a word). However, the constraint would be counter-productive in certain languages that allow stand-alone vowelless open-class words. One such language is Berber (where t is indeed a word). Berber listeners here detected words affixed to nonsense contexts with or without vowels. Length effects seen in other languages replicated in Berber, but in contrast to prior findings, word detection was not hindered by vowelless contexts. When words can be vowelless, otherwise universal constraints disfavoring vowelless words do not feature in spoken-word recognition.