Modelling Beyond Application: Epistemic and Non-epistemic Values in Modern Science

In recent years, philosophers of science have begun to realize that the clear separation of the creation of models in academia and the application of models outside science is not possible. When these philosophers address hybrid contexts in which science is entwined with policy, business, and other realms of society, these often practically oriented realms no longer represent ‘the surroundings’ of science but rather are considered an essential part of it. I argue—and demonstrate empirically—that the judgement of a theory or model conducted by scientists in such hybrid contexts may contain two parts: one is truth supportive and the other is utility oriented. In relation to the debate on science and values, the article seeks to reinforce the argument in modern philosophy of science that the boundaries between epistemic and non-epistemic values are blurred. The article stresses that non-epistemic values may be also understood as values that contribute to the instrumental success of a theory or model and—in this way—influence scientific practice in the hybrid contexts.     

Sex differences in the response to emotional distraction: an event-related fMRI investigation

Evidence has suggested that women have greater emotional reactivity than men. However, it is unclear whether these differences in basic emotional responses are also associated with differences in emotional distractibility, and what the neural mechanisms that implement differences in emotional distractibility between women and men are. Functional MRI recording was used in conjunction with a working memory (WM) task, with emotional distraction (angry faces) presented during the interval between the memoranda and the probes. First, we found an increased impact of emotional distraction among women in trials associated with high-confidence responses, in the context of overall similar WM performance in women and men. Second, women showed increased sensitivity to emotional distraction in brain areas associated with “hot” emotional processing, whereas men showed increased sensitivity in areas associated with “cold” executive processing, in the context of overall similar patterns of response to emotional distraction in women and men. Third, a sex-related dorsal–ventral hemispheric dissociation emerged in the lateral PFC related to coping with emotional distraction, with women showing a positive correlation with WM performance in left ventral PFC, and men showing similar effects in the right dorsal PFC. In addition to extending to men results that have previously been reported in women, by showing that both sexes engage mechanisms that are similar overall in response to emotional distraction, the present study identifies sex differences in both the response to and coping with emotional distraction. These results have implications for understanding sex differences in the susceptibility to affective disorders, in which basic emotional responses, emotional distractibility, and coping abilities are altered.     

Basal ganglia engagement during feedback processing after a substantial delay

The striatum has been shown to play an important role in learning from performance-related feedback that is presented shortly after each response. However, less is known about the neural mechanisms supporting learning from feedback that is substantially delayed from the original response. Since the consequences of one’s actions often do not become known until after a delay, it is important to understand whether delayed feedback can produce neural responses similar to those elicited by immediate-feedback presentation. We investigated this issue by using functional magnetic resonance imaging (fMRI) as participants performed a paired-associate learning task with 180 distinct trials. Feedback indicating response accuracy was presented immediately, after a delay of 25 min, or not at all. Both immediate and delayed feedback led to significant gains in accuracy on a posttest, relative to no feedback. Replicating previous work, we found that the caudate nuclei showed greater activation for positive feedback than for negative feedback when the feedback was presented immediately. In addition, delayed feedback also led to differential caudate activity to positive versus negative feedback. Delayed negative feedback also produced significant activation of the putamen and globus pallidus (the lentiform nucleus), relative to no feedback and delayed positive feedback. This suggests that the caudate nucleus is sensitive to the affective nature of feedback, across different time scales, while the lentiform nucleus may be particularly involved in processing the information carried by negative feedback after a substantial delay.     

De-idealization by commentary: the case of financial valuation models

Is there a unique way to de-idealize models? If not, how might the possible ways of reducing the distortion between models and reality differ from each other? Based on an empirical case study conducted in financial markets, this paper discusses how a popular valuation model (the Discounted Cash Flow model) idealizes reality and how the market participants de-idealize it in concrete market situations. In contrast to Cartwright’s view that economic models are generally over-constrained, this paper suggests that valuation models are under-constrained. This serves as the reason why the relaxation of simplifying assumptions and concretization do not work as methods of de-idealization. The paper finds that financial market participants de-idealize models using commentary that takes the form of judgment. As a conclusion, a hypothesis is formulated that proposes that the more underdetermined the model is the bigger role narrative and other pragmatic elements play in the process of model application.     

Relationship of purported measures of pathological and nonpathological dissociation to self-reported psychological distress and fantasy immersion

In order to investigate both the psychometric structure of the Dissociative Experiences Survey (DES) and the discriminant validity of the DES-Taxon (Waller, Putnam, & Carlson, 1996) as a specific marker of pathological dissociation, 376 non-clinical community based respondents completed the DES and a battery of psychopathology and imaginative involvement self-report measures. The DES was scored for both the Taxon and the DES-Absorption subscale. A DES subscale purported to tap normative dissociative processes. The two DES subscales demonstrated substantial overlap, both with each other (r = .80) and with the self-report measures with both DES scales comparably associated with high levels of psychological distress. Both DES subscales were also associated with elevated levels of "normative" imaginative involvement (fantasy proneness, absorption, daydreaming immersion). We conclude that both DES scales are largely indistinguishable from each other in relation to other self-report measures of psychopathology and fantasy access.     

Latent memory for sensitization in Aplysia

In the analysis of memory it is commonly observed that, even after a memory is apparently forgotten, its latent presence can still be revealed in a subsequent learning task. Although well established on a behavioral level, the mechanisms underlying latent memory are not well understood. To begin to explore these mechanisms, we have used Aplysia, a model system that permits the simultaneous study of memory at the behavioral, cellular, and molecular levels. We first demonstrate that robust latent memory is induced by long-term sensitization training of the tail-elicited siphon withdrawal reflex. It is revealed by its ability to facilitate the subsequent induction of three mechanistically distinct temporal domains of sensitization memory: short-term, intermediate-term, and long-term memory. Under our training conditions, the latent memory persists for at least 2 d following the decay of original memory expression but appears to be gone by 4 d. Interestingly, we also find that latent memory is induced even in the absence of overt memory for the original training. These findings now permit the analysis of the cellular and molecular architecture of a common feature of learning and memory.     

Suppression mediates the effect of 5‐HTTLPR by stress interaction on depression

A number of studies have shown that the presence of short (S), as opposed to long (L), allele of the serotonin transporter‐linked polymorphic region (5‐HTTLPR) is associated with a higher risk for depression following exposure to stressful life events. However, many other studies failed to confirm this association. One reason for this inconsistency might be the fact that the interaction of the 5‐HTTLPR polymorphism with stress may relate not to depression per se, but rather to adaptive or maladaptive emotion regulation strategies. Here we show that individuals homozygous for the long allele respond to stressful events by reappraising their emotional meaning, which may hamper the harmful effect of stress on mental health. In S genotype carriers, on the other hand, stress triggers the appearance of intrusive thoughts and vain attempts to suppress them, which in this group acts as a mediator between stress and depressive symptoms. These findings are in line with neuroimaging studies showing that 5‐HTTLPR polymorphism has an effect on the connectivity among key areas involved in emotion regulation.     

Examination of a multi-factorial model of body-related experiences during pregnancy: the relationships among physical symptoms, sleep quality, depression, self-esteem, and negative body attitudes

The aim of this cross-sectional study was to investigate relationships among women's body attitudes, physical symptoms, self-esteem, depression, and sleep quality during pregnancy. Pregnant women (N = 215) at 15–25 weeks gestation completed a questionnaire including four body image subscales assessing self-reported feeling fat, attractiveness, strength/fitness, and salience of weight and shape. Women reported on 29 pregnancy-related physical complaints, and completed the Beck Depression Inventory, Rosenberg Self-esteem Scale, and Pittsburgh Sleep Quality Index. In regressions, controlling for retrospective reports of body image, more frequent and intense physical symptoms were related to viewing the self as less strong/fit, and to poorer sleep quality and more depressive symptoms. In a multi-factorial model extending previous research, paths were found from sleep quality to depressive symptoms to self-esteem; self-esteem was found to be a mediator associated with lower scores on feeling fat and salience of weight and shape, and on higher perceived attractiveness.     

Selection of gender‐incongruent applicants: No gender bias with structured interviews

Research suggests that the use of structured interviews can reduce gender bias in hiring. However, studies have been limited to gender‐neutral professions or laboratory simulations. The current study evaluated two components of the structured interview in a field sample of 691 applicants interviewing for a male‐dominated position of public transit operator. Multilevel modeling results show no significant differences in ratings across applicant gender with this highly structured interview. This relation was found in individual interviewer ratings and consensus panel ratings, as well as irrespective of interviewer gender and interviewer participation in comprehensive versus minimal training in structured interviewing. This study provided a conservative test in a male‐dominated profession to further validate the value of the structured interview for promoting equal hiring practices.     

Experiencing past and future personal events: functional neuroimaging evidence on the neural bases of mental time travel

Functional MRI was used in healthy subjects to investigate the existence of common neural structures supporting re-experiencing the past and pre-experiencing the future. Past and future events evocation appears to involve highly similar patterns of brain activation including, in particular, the medial prefrontal cortex, posterior regions and the medial temporal lobes. This result seems to support the view of a common neurocognitive system, which would allow humans to mentally travel through time. Past events recollection was associated with greater amplitude of hippocampal and anterior medial prefrontal hemodynamic responses. This result is discussed in terms of the involvement of the self in the conscious experience of past and future events representations. More generally, our data provide new evidence in favour of the idea that re- and pre-experiencing past and future events may rely on similar cognitive capacities.