Impact of recent findings on study design of future autism clinical trials

There are specific challenges to studying the design of pharmacologic trials in child/adolescent and adult autism, such as subject stratification and parallel versus crossover designs. This article describes how optimal study design is influenced by subject selection and outcome measures chosen. Lessons learned in study design from the Research Units on Pediatric Psychopharmacology Autism Network trial with risperidone, Seaver Center trials with fluoxetine and valproate, Dartmouth trials with amantadine, and National Institutes of Health secretin trials are highlighted. The Internet System for Assessing Autistic Children system for managing multicenter clinical trials in autism and statistical issues in autism research are also described.     

A parallel process seminar for use in programs of Clinical Pastoral Education (CPE)

A seminar model is developed and used for students in Clinical Pastoral Education to explore parallel process dynamics operative in their ministry. One of the key assumptions on which this seminar is designed is that students will present material from their work with patients that carry relational dynamics that parallel the students' intra-psychic dynamics. Verbatim material presented is used in the learning group to identify and respond to the presenter's intra-psychic dynamics and their implication for ministry--to provide support, clarification, and/or confrontation with the intent of facilitating personal and professional growth.     

A meta-analytic review of prospective memory and aging

A meta-analysis of prospective memory (PM) studies revealed that in laboratory settings younger participants outperform older participants on tests of both time- and event-based PM (rs=-.39 and -.34, respectively). Event-based PM tasks that impose higher levels of controlled strategic demand are associated with significantly larger age effects than event-based PM tasks that are supported by relatively more automatic processes (rs=-.40 vs. -.14, respectively). However, contrary to the prevailing view in the literature, retrospective memory as measured by free recall is associated with significantly greater age-related decline (r=-.52) than PM, and older participants perform substantially better than their younger counterparts in naturalistic PM studies (rs=.35 and.52 for event- and time-based PM, respectively).     

Neuropsychological executive functioning in children at elevated risk for alcoholism: findings in early adolescence

One component of individual risk for alcoholism may involve cognitive vulnerabilities prodromal to alcoholism onset. This prospective study of 198 boys followed between 3 and 14 years of age evaluated neurocognitive functioning across three groups who varied in familial risk for future alcoholism. Measures of intelligence, reward-response, and a battery of neuropsychological executive and cognitive inhibitory measures were used. Executive functioning weaknesses were greater in families with alcoholism but no antisocial comorbidity. IQ and reward-response weaknesses were associated with familial antisocial alcoholism. Executive function effects were clearest for response inhibition, response speed, and symbol-digit modalities. Results suggest that executive deficits are not part of the highest risk, antisocial pathway to alcoholism but that some executive function weaknesses may contribute to a secondary risk pathway.     

Minority adolescents and substance use risk/protective factors: a focus on inhalant use

Despite the fact that inhalant use is a growing problem among youth in the United States, relatively little attention has been paid to the demographic and social factors related to its use. This study used data from a household survey of adolescents in Washington state, and found that race/ethnicity was a strong predictor of lifetime prevalence of inhalant use, with Native-American youth being particularly likely to use inhalants. Comparing the age at initiation of inhalant use to other legal and illegal substances, we found that cigarettes and inhalants showed the lowest age at initiation. We conducted logistic regressions on lifetime prevalence of inhalant use, and compared these models to other substances. In general, we found that attachment to parents. parents' drug use, and school attachment were strong predictors of lifetime use of marijuana, alcohol, and inhalants. However, while peer drug use was a strong predictor of marijuana and alcohol use, it was not a significant predictor of adolescents' use of inhalants. Our final set of analyses included inhalant use in regression models predicting other problem behaviors: these analyses demonstrated that inhalant use was a strong predictor of involvement in problem behavior.     

Comparison of two creativity style measures

The purpose of this study was to examine the relation between two measures of creativity style for a sample of beginning teachers. 116 student teachers enrolled in an undergraduate teacher-education program in a medium-sized, metropolitan university completed the Kirton Adaption-Innovation Inventory and Basadur Creative Problem Solving Profile measures. A preference for an Innovator style (higher scores on Kirton's inventory) was correlated with the Generator profile on the Basadur profile (r=.36, p<.01). The KAI Efficiency scores, suggesting a preference for broad, global ideas as opposed to narrow, specific ones, was correlated with the Basadur Conceptualizer scores (r=.26, p<.01). Implications are discussed for teachers who must adapt to newer instructional and assessment methods designed to foster students' higher-level thinking skills.     

Using broad measures of maladjustment to assess psychological states of outpatients with schizophrenia

Two broad indexes of maladjustment derived from two projective tests and administered at two separate points to the same 50 outpatients with schizophrenia showed substantial convergent validity at both testings (r=.52, p<.001; r=.58, p<.001). Conversely, test-retest reliabilities for both indexes were nonsignificant. These findings suggest that broad measures of maladjustment may be more suitable for reflecting current states of adjustment for subjects known to be diagnosed with certain symptoms, the manifestations of which fluctuate over time.