A fresh look at an ancient receptor family: emerging roles for low density lipoprotein receptors in synaptic plasticity and memory formation

The well-known family of low-density lipoprotein receptors represents a collection of ancient membrane receptors that have been remarkably conserved throughout evolution. These multifunctional receptors, known to regulate cholesterol transport, are becoming increasingly interesting to the neuroscience community due to their ability to transduce a diversity of extracellular signals across the membrane in the adult CNS. Their roles in modulating synaptic plasticity and necessity in hippocampus-specific learning and memory have recently come to light. In addition, genetic, biochemical and behavioral studies have implicated these signaling systems in a number of human neurodegenerative and neuropsychiatric disorders involving loss of cognitive ability, such as Alzheimer's disease, schizophrenia and autism. This review describes the known functions of these receptors and discusses their potential role in processes of synaptic regulation and memory formation.     

Mood states during a successful world record underwater diving attempt

The mood states of a diver were recorded over a period of almost 10 days of submersion. Scores on the Profile of Mood States obtained on the components of Depression, Anger, and Confusion suggested that there were no signs of psychological disintegration over this period. As expected, scores on Fatigue increased whereas perceived Vigor diminished over time. High Esteem remained consistent. It is proposed that profiling of mood states can be a useful monitoring tool of an acclimatization process.     

A comparison of personality function among patients with seasonal depression, nonseasonal depression, and nonclinical participants

Although a large body of research has accumulated concerning the relationship between nonseasonal depression and personality, comparatively few studies have examined the relationship between seasonal affective disorder (SAD) and personality. This study compared dimensional aspects of personality in patients diagnosed with SAD (N = 60), nonseasonal depression (N = 273), and nonclinical controls (N = 297) using the Dimensional Assessment of Personality Pathology (DAPP-BQ; Livesley & Jackson, in press). Analysis by ANCOVA indicated that significant between-group differences occurred in several of the 18 DAPP-BQ dimensions, with patients with SAD exhibiting personality psychopathology that was intermediate between the nonclinical sample and patients with nonseasonal depression. The results demonstrated that the traits associated with seasonal and nonseasonal depression differ in degree, not kind.     

Negative self-efficacy and goal effects revisited

The authors address the verification of the functional properties of self-efficacy beliefs and document how self-efficacy beliefs operate in concert with goal systems within a sociocognitive theory of self-regulation in contrast to the focus of control theory on discrepancy reduction. Social cognitive theory posits proactive discrepancy production by adoption of goal challenges working in concert with reactive discrepancy reduction in realizing them. Converging evidence from diverse methodological and analytic strategies verifies that perceived self-efficacy and personal goals enhance motivation and performance attainments. The large body of evidence, as evaluated by 9 meta-analyses for the effect sizes of self-efficacy beliefs and by the vast body of research on goal setting, contradicts findings (J. B. Vancouver, C. M. Thompson, & A. A. Williams, 2001; J. B. Vancouver, C. M. Thompson, E. C. Tischner, & D. J. Putka 2002) that belief in one's capabilities and personal goals is self-debilitating.     

Universal sex differences in the desire for sexual variety: tests from 52 nations, 6 continents,and 13 islands

Evolutionary psychologists have hypothesized that men and women possess both long-term and short-term mating strategies, with men's short-term strategy differentially rooted in the desire for sexual variety. In this article, findings from a cross-cultural survey of 16,288 people across 10 major world regions (including North America, South America, Western Europe, Eastern Europe, Southern Europe, Middle East, Africa, Oceania, South/Southeast Asia, and East Asia) demonstrate that sex differences in the desire for sexual variety are culturally universal throughout these world regions. Sex differences were evident regardless of whether mean, median, distributional, or categorical indexes of sexual differentiation were evaluated. Sex differences were evident regardless of the measures used to evaluate them. Among contemporary theories of human mating, pluralistic approaches that hypothesize sex differences in the evolved design of short-term mating provide the most compelling account of these robust empirical findings.     

Why we need a relevant theory of conditionals

This paper presents ConR (Conditional R), a logic of conditionals based on Anderson and Belnap's system R. A Routley-Meyer-style semantics for ConR is given for the system (the completeness of ConR over this semantics is proved in E. Mares and A. Fuhrmann, A Relevant Theory of Conditionals (unpublished MS)). Moreover, it is argued that adopting a relevant theory of conditionals will improve certain theories that utilize conditionals, i.e. Lewis' theory of causation, Lewis' dyadic deontic logic, and Chellas' dyadic deontic logic.I am of course deeply indebted to André Fuhrmann, who co-wrote the paper on which the present effort is based. Perhaps I should also thank the Social Sciences and Humanities Research Council of Canada because the original research for this project was funded by them in the form of a post-doctoral fellowship.     

Goal attainment scaling: An idiosyncratic method to assess treatment effectiveness in agoraphobia

Goal attainment scaling (GAS) is an individually tailored way to measure treatment gains, using a highly standardized procedure. An advantage of the method is that it takes into account individual characteristics of the patients, and at the same time the data are suitable for quantitative analysis and comparable across patients. Despite the wide acceptance and use of the method in the evaluation of psychotherapy, data on its psychometric properties are rather scarce. In the current study, GAS was used as one of several outcome measures in a research project on the effectiveness of various treatments for panic disorder with agoraphobia. Guidelines for GAS are presented as well as data on the reliability and validity of the procedure. Results indicate that the procedure is reliable, valid, and sensitive to the improvement of patients during treatment. Comparison of GAS with standardized measures revealed considerable concordance, although the clinical end status of patients diverged somewhat dependent on the measure considered.     

Self-regulation through goal setting

The extant literature on goal setting through 1990 has been reviewed and integrated by Locke and Latham (1990a). The result was the development of a theory of goal setting with special emphasis on its practical implications for the motivation of employees in organizational settings. The purpose of the present paper is twofold. First, the theory is summarized and updated with respect to research completed since publication of the 1990 book. Second, the self-regulatory effects of goal setting are described. Emphasis is given to ways that people can use goals as a self-management technique.