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Ignazio Puzzo Kiran Seunarine Kate Sully Angela Darekar Chris Clark Edmund J. S. Sonuga-Barke Graeme Fairchild 《Journal of abnormal child psychology》2018,46(7):1451-1466
Adolescents with conduct disorder (CD) and elevated callous-unemotional (CU) traits have been reported to present with a more severe and persistent pattern of antisocial behaviour than those with low levels of CU traits. However, relatively few studies have investigated whether there are differences in brain structure between these subgroups.We acquired diffusion tensor imaging data and used tract-based spatial statistics (TBSS) to compare adolescents with CD and high levels of CU traits (CD/CU+; n?=?18, CD and low levels of CU traits (CD/CU-; n?=?17) and healthy controls (HC; n?=?32) on measures of fractional anisotropy (FA), axial (AD), radial (RD) and mean (MD) diffusivity. Compared to CD/CU- adolescents, those with CD/CU+ presented increased FA and reduced RD and MD (lower diffusivity) in several tracts including: body and splenium of the corpus callosum, right inferior longitudinal fasciculus, ILF; right inferior fronto-occipital fasciculus, IFOF; left superior longitudinal fasciculus, SLF; left cerebral peduncle, bilateral internal capsule, left superior and posterior corona radiata, bilateral thalamic radiation and left external capsule. In addition, relative to CD/CU- individuals, adolescents with CD/CU+ showed lower diffusivity (indexed by reduced RD and MD) in left uncinate fasciculus and bilateral fornix. Finally, relative to healthy controls, CD/CU+ individuals showed lower diffusivity (reduced RD) in the genu and body of the corpus callosum and left anterior corona radiata. These results suggest that CD/CU+ individuals present with white-matter microstructural abnormalities compared to both CD/CU- individuals and age-matched healthy controls. This finding is consistent with emerging evidence suggesting that CD/CU+ represents a distinct subtype of CD, and illustrates the importance of accounting for heterogeneity within CD populations. 相似文献
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Theoretical Medicine and Bioethics - 相似文献
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H. Edmund Pigott John W. Fantuzzo Paul W. Clement 《Journal of applied behavior analysis》1986,19(1):93-98
We evaluated the effects of reciprocal peer tutoring combined with group reinforcement contingencies on the arithmetic performance of 12 underachieving fifth-grade students. Results indicated that the intervention increased the students' arithmetic performance to a level indistinguishable from their classmates during treatment and 12-week follow-up phases. Pre-, post-, and follow-up sociometric data indicated that the students who participated in the treatment groups increased their amount of peer affiliation with other treatment group members. 相似文献
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Journal for General Philosophy of Science - While the logical reconstruction of empirical theories is, in principle, no longer a matter of dispute, the possibility and, furthermore, the procedure... 相似文献
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Recovering substance abuse therapists had a higher sense of personal accomplishment than nonrecovering therapists. Therapists who had more social support had a greater sense of personal accomplishment. Length of service was related to greater depersonalization and greater personal accomplishment. Burnout was strongly associated with occupational stress. Personal stress was associated with depersonalization. 相似文献
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Edmund Fantino 《Journal of the experimental analysis of behavior》1968,11(1):15-22
Pigeons' responses in the presence of two concurrently available (initial-link) stimuli produced one of two different (terminal-link) stimuli according to identical but independent variable-interval schedules. Responses in the presence of each terminal-link stimulus produced equal frequencies of food reinforcement, but in the presence of one of the stimuli, food depended upon the emission of a response rate either higher or lower than a specified value (differential reinforcement of rates). The measure of preference, the dependent variable, was the distribution of responses in the presence of the concurrently available stimuli of the initial links. Each pigeon, the responding of which was appropriately controlled by the response-rate requirements in the two terminal-link stimuli, consistently preferred the stimulus not associated with a response-rate requirement. 相似文献