Contributions of Studies on Alcohol Use Disorders to Understanding Cerebellar Function

Neuropathological, neuropsychological, and neuroimaging studies of human alcoholism provide evidence for degradation of frontal, pontine, thalamic, and cerebellar brain sites and disturbed associated functions. Current studies using neuroimaging combined with examination of executive functions, traditionally considered the sole purview of the frontal lobes, have identified a role for the cerebellum serving as a compensatory processing adjunct to enable normal performance on challenging tasks tapping executive functions. This overview proposes that disruption of an executive frontocerebellar network is a major contributor to characteristic behaviors of alcoholism that, on the one hand, enable alcohol use disorders, and on the other hand, lead to compensation for dysfunctions in alcoholism traditionally considered frontally-based.     

Who Will Volunteer? Religiosity, Everyday Racism, and Social Participation Among African American Men

This study explores the relative importance of everyday racism, empathic concern, communalism, and religiosity as predictors of pro-social involvement (i.e., volunteerism and membership in political/social justice organizations) among a sample of African American men (N = 151). Church involvement emerged as a positive predictor of the likelihood that these men were involved in volunteer work as well as the number of hours that men dedicated to volunteer work. Communalism positively predicted the amount of time (in hours per year) that men were involved in volunteer work. Subjective religiosity and the stress of everyday racism were associated with a greater likelihood of being a member of a political–social justice organization. Implications of these findings are discussed.     

Eliciting and comparing false and recovered memories: an experimental approach

We describe an experimental paradigm designed to elicit both recovered and false memories in the laboratory. All participants saw, on a video screen, three critical categorized lists of words mixed in randomly with eighteen filler categorized lists. Those in the blocking condition then had several paper‐and‐pencil tasks that involved only the 18 non‐critical filler lists. An uncued recall test was then given, asking participants to recall all the lists they originally saw on the video screen. Finally, there was a cued recall test that provided category cues for the three critical lists. Substantial memory blocking of critical lists on the uncued test and recovery on the cued recall test was observed in all three experiments. In Experiments 2 and 3, many false and recovered memories were elicited on the cued recall test by including cues for the three critical (forgotten) lists, plus cues for three lists that had never been presented. False memories were distinguishable from truly recovered memories in cued recall by ‘know’ versus ‘remember’ judgements, and by confidence ratings; accurately recovered memories were associated with higher confidence. False and recovered memories could not be discriminated based on recall latency. The results repeatedly show powerful effects of memory blocking and recovery. We also show that recovered and false memories can be elicited within a single experimental procedure, and there may be unique characteristics of each. Although we urge caution in generalizing to false and recovered memories of trauma, we suggest that variations of our comparative memory paradigm may be useful for learning about such phenomena. Copyright © 2003 John Wiley & Sons, Ltd.     

Views of a good life and allostatic load: Physiological correlates of theories of a good life depend on the socioeconomic context

This research examines the relationship between one’s theory of a good life and allostatic load, a marker of cumulative biological risk, and how this relationship differs by socioeconomic status. Among adults with a bachelor’s degree or higher, those who saw individual characteristics (e.g. personal happiness, effort) as part of a good life had lower levels of allostatic load than those who did not. In contrast, among adults with less than a bachelor’s degree, those who saw supportive relationships as part of a good life had lower levels of allostatic load than those who did not. These findings extend past research on socioeconomic differences in the emphasis on individual or relational factors and suggest that one’s theory of a good life has health implications.     

Anosognosia for Memory Impairment in Addiction: Insights from Neuroimaging and Neuropsychological Assessment of Metamemory

In addiction, notably Alcohol Use Disorder (AUD), patients often have a tendency to fail to acknowledge the reality of the disease and to minimize the physical, psychological, and social difficulties attendant to chronic alcohol consumption. This lack of awareness can reduce the chances of initiating and maintaining sobriety. Presented here is a model focusing on compromised awareness in individuals with AUD of mild to moderate cognitive deficits, in particular, for episodic memory impairment—the ability to learn new information, such as recent personal experiences. Early in abstinence, alcoholics can be unaware of their memory deficits and overestimate their mnemonic capacities, which can be investigated with metamemory paradigms. Relevant neuropsychological and neuroimaging results considered suggest that the alcoholics’ impairment of awareness of their attenuated memory function can be a clinical manifestation explained mechanistically by neurobiological factors, including compromise of brain systems that result in a mild form of mnemonic anosognosia. Specifically, unawareness of memory impairment in AUD may result from a lack of personal knowledge updating attributable to damage in brain regions or connections supporting conscious recollection in episodic memory. Likely candidates are posterior parietal and medial frontal regions known to be integral part of the Default Mode Network (DMN) and the insula leading to an impaired switching mechanism between the DMN and the Central-Executive Control (i.e., Lateral Prefronto-Parietal) Network. The cognitive concepts and neural substrates noted for addictive disorders may also be relevant for problems in self-identification of functional impairment resulting from injury following war-related blast, sport-related concussion, and insidiously occurring dementia.     

Organization-based self-esteem and well-being: empirical examination of a spillover effect

Global self-esteem is believed to be a major determinant of both subjective and eudaimonic (psychological) well-being (Diener, E. (1984). Subjective well-being. Psychological Bulletin, 95, 542–575. doi:10.1037/0033-2909.95.3.542; Ryff, C. D. (1989). Happiness is everything, or is it? Explorations on the meaning of psychological well-being. Journal of Personality and Social Psychology, 57, 1069–1081. doi:10.1037/0022-3514.57.6.1069). This relationship is termed a spillover effect because it is believed that self-esteem “spills over” onto general well-being. In light of the dominant role that work plays in the lives of many people, we asked whether there is also a spillover effect of self-esteem formed around one’s work and organizational experiences (viz., organization-based self-esteem) on general well-being. Building from disposition theory we posited a positive relationship between organization-based self-esteem and well-being. Drawing upon evidence from two field studies, involving focal participant and co-worker reports, we present evidence in support of the hypothesized relationships. In addition, we observe evidence suggesting that work engagement may play a role by influencing the extent to which this spillover effect might occur. Implications of this research are discussed.     

Positive and negative affectivity,stress, and well-being in African-Americans: Initial demonstration of a polynomial regression and response surface methodology approach

Objective: The extent to which positive (PA) and negative (NA) affect conjointly impact well-being is not yet well understood. Additionally, research investigating the role of affectivity in maintaining well-being among ethnic and racial minorities is scant. The current research demonstrates how polynomial regression and response surface methodology (PR and RSM) may be used to better understand how PA and NA jointly influence stress and well-being.

Design: In Study 1, 291 African-American undergraduates (M_age = 22.91, SD = 6.91; 67% female) completed measures of affectivity and psychological well-being. In Study 2, a community sample of 117 African-Americans (M_age = 31.87, SD = 13.83; 69% female) completed affectivity measures and a laboratory-based social stressor task to assess links between affectivity and salivary cortisol reactivity.

Main outcome measures: Study 1 included life satisfaction, perceived stress and self-reported depressive symptoms. Study 2 included salivary cortisol reactivity.

Results: Across both studies, PA ascendency (i.e. high PA combined with low NA) was associated with better well-being, while NA ascendancy (i.e. high NA combined with low PA) was associated with poorer outcomes.

Conclusion: PR and RSM may provide new insight into the conjoint influence of PA and NA on health and well-being. We discuss potential implications for affectivity research, including race-related explorations.     

Fatigue following Paediatric Acquired Brain Injury and its Impact on Functional Outcomes: A Systematic Review

Fatigue is a commonly reported sequela following an acquired brain injury (ABI), and can have a negative impact on many areas of a child’s life. However, there is minimal research that focuses on fatigue specifically, and so factors such as its occurrence, duration, and impact on functioning remain uncertain. This systematic review aims to provide a comprehensive summary of the research to date, bringing together a number of studies with a focus on paediatric ABI and fatigue. Terms were searched in relevant databases (PsycInfo, Medline, CINAHL), and articles were included or excluded based on specified criteria. Of the 1177 papers identified in the original search, a total of 9 papers met inclusion criteria, and were categorised as traumatic brain injury (TBI; n?=?4), meningitis and meningococcal disease (n?=?2), brain tumours (n?=?2), and mixed ABI group (n?=?1). Key findings suggest that fatigue is a problem encountered by a significant proportion of patients in all the studies reviewed, and often occurred regardless of the cause; fatigue was also associated with poor academic achievement, limited physical activity, and social and emotional problems. Injuries of greater severity were associated with higher levels of fatigue and worse outcomes. Several management options were suggested, though their efficacy was not reported. Future research is required with a suggested focus on using multiple time points to better understand the trajectories of fatigue following childhood ABI, and to build an evidence base to determine which management options are most suitable.     

Socioeconomic differences in children's health: how and why do these relationships change with age?

The effects of socioeconomic status (SES) on health are well documented in adulthood, but far less is known about its effects in childhood. The authors reviewed the literature and found support for a childhood SES effect, whereby each decrease in SES was associated with an increased health risk. The authors explored how this relationship changed as children underwent normal developmental changes and proposed 3 models to describe the temporal patterns. The authors found that a model's capacity to explain SES-health relationships varied across health outcomes. Childhood injury showed stronger relationships with SES at younger ages, whereas smoking showed stronger relationships with SES in adolescence. Finally, the authors proposed a developmental approach to exploring mechanisms that link SES and child health.