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Eva M. Müller-Oehring Rosemary Fama Taylor F. Levine Cheshire Hardcastle Ryan Goodcase Talora Martin Varsha Prabhakar Helen M. Brontë-Stewart Kathleen L. Poston Edith V. Sullivan Tilman Schulte 《Journal of Neuropsychology》2021,15(2):253-273
Despite the life-extending success of antiretroviral pharmacotherapy in HIV infection (HIV), the prevalence of mild cognitive impairment in HIV remains high. Near-normal life expectancy invokes an emerging role for age–infection interaction and a potential synergy between immunosenescence and HIV-related health factors, increasing risk of cognitive and motor impairment associated with degradation in corticostriatal circuits. These neural systems are also compromised in Parkinson’s disease (PD), which could help model the cognitive deficit pattern in HIV. This cross-sectional study examined three groups, age 45–79 years: 42 HIV, 41 PD, and 37 control (CTRL) participants, tested at Stanford University Medical School and SRI International. Neuropsychological tests assessed executive function (EF), information processing speed (IPS), episodic memory (MEM), visuospatial processing (VSP), and upper motor (MOT) speed and dexterity. The HIV and PD deficit profiles were similar for EF, MEM, and VSP. Although only the PD group was impaired on MOT compared with CTRL, MOT scores were related to cognitive scores in HIV but not PD. Performance was not related to depressive symptoms, socioeconomic status, or CD4+ T-cell counts. The overlap of HIV-PD cognitive deficits implicates frontostriatal disruption in both conditions. The motor-cognitive score relation in HIV provides further support for the hypothesis that these processes share similar underlying mechanisms in HIV infection possibly expressed with or exacerbated by ageing. 相似文献
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The Battle of the Screens: Unraveling Attention Allocation and Memory Effects When Multiscreening
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Multiscreening, the simultaneous usage of multiple screens, is a relatively understudied phenomenon that may have a large impact on media effects. First, we explored people's viewing behavior while multiscreening by means of an eye‐tracker. Second, we examined people's reporting of attention, by comparing eye‐tracker and self‐reported attention measures. Third, we assessed the effects of multiscreening on people's memory, by comparing people's memory for editorial and advertising content when multiscreening (television–tablet) versus single screening. The results of the experiment (N = 177) show that (a) people switched between screens 2.5 times per minute, (b) people were capable of reporting their own attention, and (c) multiscreeners remembered content just as well as single screeners, when they devoted sufficient attention to the content. 相似文献
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