Hippocampal PKA/CREB pathway is involved in the improvement of memory induced by spermidine in rats

Spermidine (SPD) is an endogenous polyamine that modulates N-methyl-D-aspartate (NMDA) receptor function, and has been reported to facilitate memory formation. In the current study we determined whether or not the PKA/CREB signaling pathway is involved in SPD-induced facilitation of memory of inhibitory avoidance task in adult rats. The post-training administration of the cAMP-dependent protein kinase (PKA) inhibitor, N-[2-bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide [H-89, 0.5 ρmol intrahippocampal (ih)] or the antagonist of the NMDA receptor polyamine-binding site (arcaine, 0.02 nmol ih) with SPD (0.2 nmol ih) prevented memory improvement induced by SPD. Intrahippocampal administration of SPD (0.2 nmol) facilitated PKA and cAMP response element-binding protein (CREB) phosphorylation in the hippocampus 180 min, but not 30 min, after administration, and increased translocation of the catalytic subunit of PKA into the nucleus. Arcaine (0.02 nmol) and H-89 (0.5 ρmol) prevented the stimulatory effect of SPD on PKA and CREB phosphorylation. These results suggest that memory enhancement induced by the ih administration of SPD involves the PKA/CREB pathways in rats.     

Exogenous influences on task set activation in task switching

To explore the effect of exogenous processes on cognitive control, we used a cueing task-switching paradigm with two spatial judgement tasks and added an irrelevant colour attribute to the task-relevant spatial attribute of the target. The colour was not related to any specific Stimulus–Response relation in the tasks. A correlation was created between stimulus colour and task identity. This correlation was strong but imperfect in Experiment 1 and perfect in Experiment 2. As a result of the colour–task correlation, stimuli contained redundant information about task identity. By changing the correlation pattern every few blocks we caused this information to be sometimes invalid. In both experiments, performance was worse when the information carried by the target was invalid than when it was valid. However, this effect was exclusive to conditions with short task preparation time. By comparing performance with a control group, which had no colour–task correlation (in Experiment 2) we established that the colour manipulation did not cause a qualitative change in preparation strategy, and that the exogenous effect was stronger in switch trials than in repetition trials. We conclude that exogenous processes that are related to task set affect performance primarily if they are presented before endogenous processes of task set preparation have been launched.     

Reviews of current books

Pastoral Psychology -     

Contrasts and correlations in effect-size estimation

This article describes procedures for presenting standardized measures of effect size when contrasts are used to ask focused questions of data. The simplest contrasts consist of comparisons of two samples (e.g., based on the independent t statistic). Useful effect-size indices in this situation are members of the g family (e.g., Hedges's g and Cohen's d ) and the Pearson r . We review expressions for calculating these measures and for transforming them back and forth, and describe how to adjust formulas for obtaining g or d from t , or r from g , when the sample sizes are unequal. The real-life implications of d or g calculated from t become problematic when there are more than two groups, but the correlational approach is adaptable and interpretable, although more complex than in the case of two groups. We describe a family of four conceptually related correlation indices: the alerting correlation, the contrast correlation, the effect-size correlation, and the BESD (binomial effect-size display) correlation. These last three correlations are identical in the simple setting of only two groups, but differ when there are more than two groups.     

The interplay of memory and judgment processes in effects of aging on hindsight bias

Hindsight bias is the phenomenon that after people are presented with the correct answer to a question, their judgment regarding their own past answer to this question is biased toward the correct answer. In three experiments, younger and older adults gave numerical responses to general-knowledge questions and later attempted to recall their responses. For some questions, the correct answer was provided during recall (Experiment 1) or before recall (Experiments 2 and 3). Multinomial model-based analyses show age differences in both recollection bias and reconstruction bias when the correct judgment was in working memory during the recall phase. The authors discuss implications for theories of cognitive aging and theories of hindsight bias.     

On the origins of the task mixing cost in the cuing task-switching paradigm

Poorer performance in conditions involving task repetition within blocks of mixed tasks relative to task repetition within blocks of single task is called mixing cost (MC). In 2 experiments exploring 2 hypotheses regarding the origins of MC, participants either switched between cued shape and color tasks, or they performed them as single tasks. Experiment 1 supported the hypothesis that mixed-tasks trials require the resolution of task ambiguity by showing that MC existed only with ambiguous stimuli that afforded both tasks and not with unambiguous stimuli affording only 1 task. Experiment 2 failed to support the hypothesis that holding multiple task sets in working memory (WM) generates MC by showing that systematic manipulation of the number of stimulus-response rules in WM did not affect MC. The results emphasize the role of competition management between task sets during task control.     

From Environmental Factors to Outcomes: A Test of an Integrated Motivational Sequence

Research based on self-determination theory (SDT; E. L. Deci & R. M. Ryan, 1985, 2000) has shown that motivation is influenced by the social environment and also leads to outcomes. Based on such research, R. J. Vallerand (1997) has posited the existence at different levels of generality of an integrated motivational sequence where environmental factors (e.g., success/failure) influence perceptions of competence, autonomy, and relatedness (psychological mediators), which in turn determine to what extent one exhibits self-determined motivation. Motivation then leads to outcomes. The present study tested the validity of this integrated sequence at the situational level using an experimental design. Participants (N = 359) were randomly assigned to conditions of success or failure on a leisure task and elements of the integrated sequence were assessed. Structural equation modeling analyses provided support for the postulated motivational sequence. Results are discussed in light of SDT.This research was supported by grants and fellowships from the Fonds pour la formation de chercheurs et laide à la recherche (FCAR) and the Social Sciences Humanities Research Council of Canada (SSHRC) to Robert J. Vallerand. We would like to thank Sandrine Passelaigue for her help in collecting the data.