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81.
de Oliveira AR Reimer AE de Macedo CE de Carvalho MC Silva MA Brandão ML 《Neurobiology of learning and memory》2011,95(1):37-45
Excitation of the mesocorticolimbic pathway, originating from dopaminergic neurons in the ventral tegmental area (VTA), may be important for the development of exaggerated fear responding. Among the forebrain regions innervated by this pathway, the amygdala is an essential component of the neural circuitry of conditioned fear. The functional role of the dopaminergic pathway connecting the VTA to the basolateral amygdala (BLA) in fear and anxiety has received little attention. In vivo microdialysis was performed to measure dopamine levels in the BLA of Wistar rats that received the dopamine D(2) agonist quinpirole (1 μg/0.2 μl) into the VTA and were subjected to a fear conditioning test using a light as the conditioned stimulus (CS). The effects of intra-BLA injections of the D(1) antagonist SCH 23390 (1 and 2 μg/0.2 μl) and D(2) antagonist sulpiride (1 and 2 μg/0.2 μl) on fear-potentiated startle (FPS) to a light-CS were also assessed. Locomotor performance was evaluated by use of open-field and rotarod tests. Freezing and increased dopamine levels in the BLA in response to the CS were both inhibited by intra-VTA quinpirole. Whereas intra-BLA SCH 23390 did not affect FPS, intra-BLA sulpiride (2 μg) inhibited FPS. Sulpiride's ability to decrease FPS cannot be attributed to nonspecific effects because this drug did not affect motor performance. These findings indicate that the dopamine D(2) receptor pathway connecting the ventral tegmental area and the basolateral amygdala modulates fear and anxiety and may be a novel pharmacological target for the treatment of anxiety. 相似文献
82.
Daniel M. Bernstein Michael E. Rudd Edgar Erdfelder Ryan Godfrey Elizabeth F. Loftus 《Psychonomic bulletin & review》2009,16(3):463-468
Participants provided information about their childhood by rating their confidence about whether they had experienced various
events (e.g., “broke a window playing ball”). On some trials, participants unscrambled a key word from the event phrase (e.g.,
wdinwo—window) or an unrelated word (e.g., gnutge—nugget) before seeing the event and giving their confidence ratings. The act of unscrambling led participants to increase their
confidence that the event occurred in their childhood, but only when the confidence rating immediately followed the act of
unscrambling. This increase in confidence mirrors the “revelation effect” observed in word recognition experiments. In the
present article, we analyzed our data using a new signal detection mixture distribution model that does not require the researcher
to know the veracity of memory judgments a priori. Our analysis reveals that unscrambling a key word or an unrelated word
affects response bias and discriminability in autobiographical memory tests in ways that are very similar to those that have
been previously found for word recognition tasks. 相似文献
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85.
Bayen UJ Erdfelder E Bearden JN Lozito JP 《Journal of experimental psychology. Learning, memory, and cognition》2006,32(5):1003-1018
Hindsight bias is the phenomenon that after people are presented with the correct answer to a question, their judgment regarding their own past answer to this question is biased toward the correct answer. In three experiments, younger and older adults gave numerical responses to general-knowledge questions and later attempted to recall their responses. For some questions, the correct answer was provided during recall (Experiment 1) or before recall (Experiments 2 and 3). Multinomial model-based analyses show age differences in both recollection bias and reconstruction bias when the correct judgment was in working memory during the recall phase. The authors discuss implications for theories of cognitive aging and theories of hindsight bias. 相似文献
86.
Frederick M. E. Grouzet Robert J. Vallerand Edgar E. Thill Pierre J. Provencher 《Motivation and emotion》2004,28(4):331-346
Research based on self-determination theory (SDT; E. L. Deci & R. M. Ryan, 1985, 2000) has shown that motivation is influenced by the social environment and also leads to outcomes. Based on such research, R. J. Vallerand (1997) has posited the existence at different levels of generality of an integrated motivational sequence where environmental factors (e.g., success/failure) influence perceptions of competence, autonomy, and relatedness (psychological mediators), which in turn determine to what extent one exhibits self-determined motivation. Motivation then leads to outcomes. The present study tested the validity of this integrated sequence at the situational level using an experimental design. Participants (N = 359) were randomly assigned to conditions of success or failure on a leisure task and elements of the integrated sequence were assessed. Structural equation modeling analyses provided support for the postulated motivational sequence. Results are discussed in light of SDT.This research was supported by grants and fellowships from the Fonds pour la formation de chercheurs et laide à la recherche (FCAR) and the Social Sciences Humanities Research Council of Canada (SSHRC) to Robert J. Vallerand. We would like to thank Sandrine Passelaigue for her help in collecting the data. 相似文献
87.
Smith BR Piel AK Candland DK 《Journal of comparative psychology (Washington, D.C. : 1983)》2003,117(2):217-225
To extend a study conducted by E. M. Brannon and H. S. Terrace (1998, 2000), the authors trained 1 hamadryas baboon (Papio hamadryas) and 1 squirrel monkey (Saimiri sciureus) to respond to stimuli representing the numerosities 1-4 in ascending order. When tested with novel stimuli of the same numerosities, both subjects' performance appeared to be based on the numerical attributes of stimuli. Subjects were then tested on their ability to order pairs of numerosities derived from the values 1-9. Both subjects successfully ordered pairs that included the untrained numerosities 5-9 regardless of the total surface area of numerosities. Accuracy and latency of responding also showed numerical distance and magnitude effects. Numerosity was a salient cue to both subjects, suggesting that these 2 families of primates perceive ordinal relations. The outcome shows that cognitive studies of this type can be effectively conducted with socially housed animals. 相似文献
88.
Light energy displaced along the retinal photoreceptor array leads to a perception of visual motion. In audition, displacement of mechanical energy along the cochlear hair cell array is conceptually similar but leads to a perception of 'movement' in frequency space (spectral motion)--a rising or falling pitch. In vision there are other types of stimuli that also evoke a percept of motion but do not involve a displacement of energy across the photoreceptors (second-order stimuli). In this study, we used psychophysical methods to determine if such second-order stimuli also exist in audition, and if the resulting percept would rival that of first-order spectral motion. First-order auditory stimuli consisted of a frequency sweep of sixteen non-harmonic tones between 297 and 12123 Hz. Second-order stimuli consisted of the same tones, but with a random subset turned on at the beginning of a trial. During the trial, each tone in sequence randomly changed state (ON-to-OFF, or OFF-to-ON). Thus, state transitions created a 'sweep' having no net energy displacement correlated to the sweep direction. At relatively slow sweep speeds, subjects readily identified the sweep direction for both first-order and second-order stimuli, though accuracy decreased for second-order stimuli as the sweep speed increased. This latter characteristic is also true of some second-order visual stimuli. These results suggest a stronger parallelism between auditory and visual processing than previously appreciated. 相似文献
89.
Maria M. Piñango Edgar Zurif Ray Jackendoff 《Journal of psycholinguistic research》1999,28(4):395-414
This study reports results on the real-time consequences of aspectual coercion. We define aspectual coercion as a combinatorial semantic operation requiring computation over and above that provided by combining lexical items through expected syntactic processes. An experiment is described assessing whether or not parsing of a string requiring coercion—in addition to syntactic composition—is more computationally costly than parsing a syntactically transparent counterpart, a string that provides for an interpretable representation via syntactic composition alone. The prediction of a higher computational cost for this process is borne out by the results. 相似文献
90.