Concentration-dependent effects of protein phosphatase (PP) inhibitors implicate PP1 and PP2A in different stages of memory formation

Numerous studies have demonstrated roles for protein phosphorylation and for specific kinases in memory formation; however, a role for specific protein phosphatases has not been established. Previous studies using pharmacobehavioral methods to implicate protein phosphatase activity in memory formation have been unable to discriminate between protein phosphatases 1 (PP1) and 2A (PP2A), as available cell-permeable agents generally inhibit both enzyme classes. To address this difficulty the present study exploited differences in the potency of the selective phosphatase inhibitor, okadaic acid, toward PP1 and PP2A. Within the context of a temporally precise animal model of memory, developed using the day-old chick (Gallus domesticus), acute administration of various concentrations of okadaic acid was found to disrupt two temporally distinct stages of memory formation. When administered bilaterally into an area of the chick brain implicated in memory formation, concentrations of okadaic acid known to selectively inhibit PP2A in vitro disrupted memory from 50 min posttraining. Higher concentrations, reported to inhibit both PP2A and PP1 in vitro, produced significant retention deficits from 20 min posttraining. Identical temporally specific effects were also obtained by varying the concentration and time of administration of calyculin A, a phosphatase inhibitor with equal potency toward both enzyme classes. Hence, different phosphatase enzymes may contribute to different stages of the enzymatic cascade believed to underlie memory formation.     

Religion and Therapy: Religious Conversion and the Mental Health of Chronic Heroin-Addicted Persons

Eighty-six Chinese heroin-addicted men from different stages of a gospel drug rehabilitation programme, including the pre-conversion stage (N = 26), post-conversion stage (N = 20), halfway house stage (N = 19), and peer leaders stage (N = 21) were recruited. Participants responded to instruments assessing their depressive symptoms, sense of hopelessness, and purpose in life. Results showed that there was (a) a decrease of depressive symptoms, (b) a decrease of hopelessness symptoms, and (c) an increase of purpose in life through the different stages of the gospel drug rehabilitation program.     

Attributing causality and remembering events in individual- and group-acting situations: A Beijing, Hong Kong, and Wellington comparison

Previous research has shown that collectivists prefer external whereas individualists prefer internal attributions. To test the findings' generality across social situations, we compared the two attributions in situations where either an individual was acting on a group (Individual-acting) or the reverse (Group-acting). As predicted, collectivists' (Beijing and Hong Kong Chinese) greater preference for externality, and individualists' (Wellington Europeans) greater preference for internality, occurred in individual- but not group-acting situations. Collectivists' (mainly Hong Kong) memory of events was better in group- than in individual-acting situations according to prediction, but the predicted reversal was not found among individualists. The collectivist/individualist categorizations of the samples were supported by measures of self-construal. Indigenous Chinese concepts of 'unity' ( tong tian ren ) and 'combination' ( he nei wai ) were discussed to throw light on attribution processes that are not readily accessible through the concepts of collectivism and individualism.     

OHTSUKI KENJI AND THE BEGINNINGS OF LAY ANALYSIS IN JAPAN

The authors outline the major role played by Ohtsuki Kenji in the formation of the Japanese Psychoanalytic Society. Unlike the other pioneers of psychoanalysis in Japan, Ohtsuki never went abroad or met Freud. He was a literature graduate who taught himself the fundamentals of psychoanalysis. He organised the translation of Freud's complete works, formed a psychoanalytic training institute and started a journal that carried English-language editorials. These became the major means whereby foreign analysts came to know and understand the Japanese psychoanalytic scene. A number of rival groups amalgamated to form the Japanese Psychoanalytical Association in the mid-fifties, excluding Ohtsuki's group despite its pre-war prominence. The authors reconsider Ohtsuki's role in the light of his many articles, his autobiography, new information uncovered in interviews conducted with current analysts and with Ohtsuki's widow and son. They describe his championing of lay analysis, and his criticisms of medicalisation of the discipline and of the view from abroad that questioned the suitability of Japanese culture for psychoanalytic therapy, as well as his efforts to modify some of the basic tenets of psychoanalysis to accord with his own views in his later work.     

The world of competitive Scrabble: Novice and expert differences in visuopatial and verbal abilities

Competitive Scrabble players spend a mean of 4.5 hr a week memorizing words from the official Scrabble dictionary. When asked if they learn word meanings when studying word lists, only 6.4% replied "always," with the rest split between "sometimes" and "rarely or never." Number of years of play correlated positively with expertise ratings, suggesting that expertise develops with practice. To determine the effect of hours of practice (M = 1,904), the authors compared experts with high-achieving college students on a battery of cognitive tests. Despite reporting that they usually memorize word lists without learning meanings, experts defined more words correctly. Reaction times on a lexical decision task (controlling for age) correlated with expertise ratings, suggesting that experts develop faster access to word identification. Experts' superiority on visuospatial processing was found for reaction time on 1 of 3 visuospatial tests. In a study of memory for altered Scrabble boards, experts outperformed novices, with differences between high and low expertise on memory for boards with structure-deforming transformations. Expert Scrabble players showed superior performance on selected verbal and visuospatial tasks that correspond to abilities that are implicated in competitive play.     

Causal attribution for interfirm contract violation: a comparative study of Chinese and American commercial arbitrators

In this study, the authors examined differences between Chinese and American commercial arbitrators. They predicted and found that Chinese arbitrators make higher awards for interfirm contract violations than Americans. This difference is partially explained by differences in attributions. Prior theory suggests, and the authors found, that the Chinese tend to have more internal attributions for events when observing group actions. When evidence provided to arbitrators is mixed (evidence is provided for both internal and external attributions), Chinese-American differences in awards become even stronger.     

Unique pathways to resilience across cultures

An international mixed methods study of resilience of 14 sites in eleven countries identified seven tensions that youth resolve in culturally specific ways. Resolution of these tensions is foundational to experiences of resilience. This paper reports on the qualitative findings from interviews with 89 youth. Results support a culturally embedded understanding of positive youth development that better accounts for young people's resilience in western and non-western countries. Specifically, the seven tensions identified include: access to material resources, relationships, identity, cohesion, power and control, social justice, and cultural adherence. Findings show that no one pattern in the resolution of these tensions predicts resilience better than another. A case study of a Palestinian boy demonstrates the intersection of the seven tensions and the uniqueness of their resolution. The implications of this work for interventions is discussed.     

青少年自尊与攻击的关系：中介变量和调节变量的作用

以705名初、高中生为被试,采用量表法和同伴提名法收集数据,探讨了自尊与攻击的关系以及对二者关系可能有影响的中介变量和调节变量的作用。结果表明：（1）自尊与攻击的相关系数为-0.21,这说明低自尊与高攻击有关;（2）回归方程纳入自控后,自尊对攻击的预测在统计意义上不明显,表明自尊通过自控对攻击产生影响,自控在自尊与攻击的关系中起着中介的作用;（3）社会地位对自尊与攻击之间的关系具有调节作用,它调节着两者关系的强度;（4）社会影响对自控的中介作用具有调节作用     

Responses of dairy heifers to the visual cliff formed by a herringbone milking pit: evidence of fear of heights in cows (Bos taurus)

The ability of cows (Bos taurus) to perceive depth has never been experimentally investigated. If cows can perceive depth, the milking pit in commercial milking facilities may be fear provoking for dairy cows, as past research has shown that most land-dwelling species possess an instinctive fear of heights. In the current study, 12 dairy heifers (1-year-old cows) were exposed to a milking pit (depth-exposed group) and 13 heifers (control group) were exposed to a standard change in the environment while they moved through a milking facility over a 5-day treatment period. Heifers in the depth-exposed group showed a higher heart rate (p < .05) and stopped more often (p < .05) than did those in the control group; persistence of heart rate but not of behavioral responses on repeated exposures indicated that some habituation to the depth stimulus had occurred. Depth exposure had no effect on cortisol concentrations or on ease of handling. These results indicate that heifers responded differently to a change in depth than they did to a standard change in the environment and provide evidence of both depth perception and acute fear of heights in cows.