A portable defense of the Procreation Asymmetry

Abstract

The Procreation Asymmetry holds that we have strong moral reasons not to create miserable people for their own sakes, but no moral reasons to create happy people for their own sakes. To defend this conjunction against an argument that it leads to inconsistency, I show how recognizing ‘creation’ as a temporally extended process allows us to revise the conjuncts in a way that preserves their intuitive force. This defense of the Procreation Asymmetry is preferable to others because it does not require us to take on controversial metaphysical or metaethical commitments – in other words, it has the theoretical virtue of portability.     

大学生弱势群体的伦理社会处境分析与思考

随着高校招生规模的不断扩大,大学生中弱势群体的绝对数量也大大增加,成为高校必须正视、重视和关注的特殊群体.从共性角度对这一特殊群体面临的两大伦理困境:挫折感强和社会认同感弱进行了深层解析;从类特性的角度对其他伦理问题进行了有益的探究和思考.     

重新构建先天性心脏病的学科新模式

现有先天性心脏病防治模式存在明显不足.为了更加有利于患者的治疗及先心病的学科发展,建议重新构建先心病学科新模式,将先心病独立成科,内外科融为一体,使先心病学科向专业化发展.     

天水“卦台山”与伏羲易学文化——从人文地理学和民俗学视角的探讨

天水市三阳川的卦台山是伏羲“仰观俯察”观物取象(则之)和创造原始易学的历史缩影.由于后人的不断附会,卦台山被人格化,周围的山、水和村庄被赋予了生命,三阳川卦台山下的十二村庄和二十四个自然村也被喻为十二生肖和二十四节气,从而构成了一幅美妙的原始天象(文)图.《周易》作为中华民族的源头文化,在天水时空上的重合,表明《周易·系辞下》所说伏羲”仰观天文,俯察地理”而画八卦的描述以及史书记载的伏羲诞生于成纪(天水)并不是空穴来风,应该是历史因子、口传史和实物的契合.     

Career decision status as a predictor of resignation behavior five years later

This paper extends earlier research exploring the relationship between career decision status and work outcomes by examining resignation behavior in a group of new graduates five years after initial appointment. On appointment various measures were collected including career decision status variables. Earlier research identified a significant relationship between a number of important work outcomes and career decision status. In the current study two variables–career decidedness and career choice importance–predicted resignation behavior. Those people who on appointment scored higher on career decidedness or lower on career choice importance were significantly more likely to stay in the organization than others. The implications of this finding for individuals and organizations are discussed.     

研究心理理论的新方法——失言识别任务

心理理论是对他人心理状态进行推论的能力。考察心理理论的经典范式是错误信念任务, 而青少年和成人在这种任务上可能出现天花板效应。为了测量青少年和成人的心理理论, Valerie E. Stone和她的合作者设计了失言识别任务。征求了Stone意见, 对失言识别任务的提出、构成、使用进行了介绍, 说明了该任务相对于经典范式的优势; 与此同时, 分析了失言识别任务范式存在的一些问题, 比如其效度指标问题, 与言语能力的分离问题, 失言识别任务与执行功能之间的分离等。未来研究可以尝试编制失言识别任务的本土化的量表, 并利用其探讨年长个体心理理论水平发展变化的规律。     

应激性抑郁样行为发生中海马5-羟色胺1A受体的作用及其对NMDA受体和AMPA受体的调节

为探讨慢性不可预见性温和应激(chronic unpredictable mild stress, CUMS)诱发抑郁样行为发生中海马5-羟色胺1A受体(5-hydroxytryptamine receptor 1A, 5-HT1AR)表达与作用, 及其对谷氨酸N-甲基-D-天冬氨酸(N-methyl-D-aspartic acid, NMDA)受体和α-氨基羟甲基异恶唑丙酸(α-amino-3-hydroxy-5- methylisoxazole-4-propionic acid, AMPA)受体的影响。通过建立CUMS动物模型, 给应激抑郁模型大鼠海马微量注射5-HT1A受体激动剂、给正常大鼠海马微量注射5-HT1A受体拮抗剂, 测量大鼠体重变化率, 并采用糖水偏爱测试、旷场实验和悬尾实验等方法对大鼠进行行为学检测, 运用Western blot和ELISA方法检测大鼠海马组织中5-HT1AR和NMDAR和AMPAR的关键亚基的表达以及磷酸化水平。结果显示, 与对照组相比, CUMS组大鼠表现出抑郁样行为, 海马5-HT1AR、AMPA受体的GluR2/3亚基表达及磷酸化明显降低, NMDA受体的NR1和NR2B亚基表达及磷酸化显著增加; 正常大鼠海马微量注射5-HT1A受体拮抗剂WAY100635, 动物行为学表现及AMPA受体、NMDA受体表达及磷酸化水平均与CUMS组相同; 注射5-HT1A受体激动剂8-OH-DPAT能逆转应激诱导的上述改变。以上结果表明, CUMS诱发抑郁样行为与海马5-HT1AR表达下降, AMPAR表达量及磷酸化水平降低, NMDAR表达量及磷酸化水平升高有关。5-HT通过5-HT1AR产生抗抑郁作用。5-HT1AR激动剂抗抑郁作用与降低NMDAR表达量及磷酸化水平, 提高AMPAR表达量及磷酸化水平密切相关。