Engineering Values Into Genetic Engineering: A Proposed Analytic Framework for Scientific Social Responsibility

Recent experiments have been used to “edit” genomes of various plant, animal and other species, including humans, with unprecedented precision. Furthermore, editing the Cas9 endonuclease gene with a gene encoding the desired guide RNA into an organism, adjacent to an altered gene, could create a “gene drive” that could spread a trait through an entire population of organisms. These experiments represent advances along a spectrum of technological abilities that genetic engineers have been working on since the advent of recombinant DNA techniques. The scientific and bioethics communities have built substantial literatures about the ethical and policy implications of genetic engineering, especially in the age of bioterrorism. However, recent CRISPr/Cas experiments have triggered a rehashing of previous policy discussions, suggesting that the scientific community requires guidance on how to think about social responsibility. We propose a framework to enable analysis of social responsibility, using two examples of genetic engineering experiments.     

JOB CHARACTERISTICS AND WELL-BEING AT MIDLIFE Ethnic and Gender Comparisons

Lacking in the research on work and well-being is a focus on the characteristics of the employment role that contribute to well-being and their differential relations across ethnicity and gender. White and Black women and men at midlife (ages 40-64) were studied. The samples were drawn from two national surveys and included 186 White women, 202 White men, 254 Black women, and 169 Black men. Multiple regression analyses were conducted to assess the relation of work commitment, job satisfaction, role stress, occupational status and personal income to perceived control, life satisfaction, and happiness. Marital status, age, and hours worked were included as control variables. Results indicate that job satisfaction is positively related to life satisfaction for all four groups, and to happiness for White women and Black men. Personal income is positively related to perceived control for Black women and White men, and to life satisfaction for White women. Occupational status is positively related to perceived control for White and Black women; role stress is negatively related to life satisfaction among White men, and to happiness among Black women. Among the control variable, being married positively related to well-being for all four race-sex groups.     

Research on Women of Color

Evidence that women of color are dealt with as anomalies in psychological research is discussed in order to: (a) inform researchers about the omissions, (b) stimulate interest in increased inclusion of women of color among research populations, and (c) demonstrate the need for increased diversity in research paradigms. It is noted that research paradigms directed at the study of the universal woman have in actuality focused on White middle class populations. This article examines the methodological and theoretical transformations that have occurred in the literature, and evaluates the extent to which researchers have successfully incorporated ethnicity into the study of gender issues. This is a call for an examination of women's experiences relative to ethnicity and a paradigmatic shift in the assumptions about what is worthy or appropriate for investigation.     

FEMINIST RESEARCH METHODS A Content Analysis of Psychology and Social Science Textbooks

This research examined the extent to which research methods textbooks in psychology and general social science discuss feminist challenges and approaches to social science (N = 40 textbooks). Two dimensions were examined. First, within the nonsexist dimensions, textbooks were analyzed to determine if they used nonsexist language and if they discussed ways to avoid sexist bias in research. The second dimension was profeminist. Within this dimension four subdomains receiving considerable attention from feminist researchers were explored: (a) epistemology (or ways of knowing); (b) objectivity and subjectivity; (c) the relationship between the researcher and the researched; and (d) qualitative versus quantitative methodologies. Results demonstrated that although the majority of the textbooks did not use sexist language, they did not move much beyond this standard. There was little discussion of feminist challenges to these research issues. When the textbook authors did mention these topics, their analyses were most often inconsistent with feminist approaches.     

Some correlates of health locus of control among multicultural individuals

The relationship of locus of control to depression, anxiety, hostility, and physical health was assessed in a sample of multicultural college students (N = 162). Powerful Others Health Locus of Control was correlated with depression, anxiety, hostility, and recent physical symptoms while Chance Health Locus of Control (CHLC) was correlated with all of the above as well as chronic physical symptoms and major health problems. When controlling for a variety of health risk factors (viz., age, sex, body mass, exercise, smoking, salt, alcohol, and caffeine), only CHLC remained significant in the physical health models. Results support the cognitive model of mental health which emphasize the importance of adaptive beliefs. Specifically, they suggest that issues about control are related to negative affect and indicate that the often-cited relationship of an external locus of control to depression and anxiety also holds for hostility. The findings do not, however, support the view that anxiety and depression are associated with different types of external locus of control but rather suggest a unified set of locus of control beliefs underlying the three types of negative affect. In addition, evidence is provided for the external validity of the Multidimensional Health Locus of Control (MHLC) Scales with respect to mental health. Further, the results indicate that belief about one’s health may play a significant role in one’s physical health and that the health behavior model of the relationship between locus of control and physical health is insufficient to explain the relationship. As the Chance and Powerful Others MHLC scales were not related to health habits in this sample but were related to mental health (viz., depression, anxiety, and hostility), locus of control beliefs may be related to physical health via their relationship with mental health.     

The short-form Buss-Perry Aggression Questionnaire (BPAQ-SF): a validation study with federal offenders

The 12-item short form of the Buss-Perry Aggression Questionnaire (BPAQ-SF) was originally developed by Bryant and Smith (2001) and modified and confirmed using confirmatory factor analysis with mentally ill offenders by Diamond, Wang, and Buffington-Vollum (2005). In the current study, construct validity of the BPAQ-SF was assessed with a sample of 1,181 male and 435 female general population federal offenders. Confirmatory factor analysis supported the four-factor structure. Tests confirmed factorial invariance across gender for all loadings and covariances. Reliabilities were found to be adequate and comparable to those found in the studies cited above. Concurrent validity was supported by high correlations between the subscales of the BPAQ-SF and several relevant subscales on the Personality Assessment Inventory (PAI). In addition, those offenders with prior history of violence, head injuries, childhood abuse, residential treatment, custody, or foster care as a child had higher scores on the BPAQ subscales.     

Interactive effects of APOE and CHRNA4 on attention and white matter volume in healthy middle-aged and older adults

In the present study, we investigated age-related changes in interactions between efficiency of neuronal repair mechanisms and efficiency of cholinergic neurotransmission in the context of attentional orienting. In addition, we explored white matter volume changes as possible neuronal underpinnings. A sample of 230 healthy middle-aged (53–64 years) and older (65–75 years) adults was genotyped for polymorphisms of APOE and CHRNA4, a nicotinic receptor subunit gene. Participants were administered a visuospatial attention task involving letter discrimination with location cues of varying validity. Genotype effects on white matter volume were also investigated in a subset of participants who received MRI scans. APOE interacted with CHRNA4, such that APOE-ε4 carriers who were also CHRNA4 TT homozygotes showed disproportionately slowed reaction time (RT) following invalid location cues. The interaction was stronger in the middle-aged participants than in the older participants. There was also a trend for individuals with combined APOE-ε4/CHRNA4 TT genotypes to show both lower white matter volume and slower overall RT on the attention task. The interaction of a neurotransmission gene (CHRNA4) and a susceptibility gene (APOE) suggests that the efficiency of neuronal repair mechanisms may modulate the cholinergic system to influence attentional function.     

Regarding time-sharing with convergent operations

This study contrasts the structural bottleneck and the resource view of attentional limits in time-sharing performance. The research incorporated features of the psychological refractory period (PRP) and the relative priority paradigm designed to maximize joint performance. A main distinction between the two attention views was their prediction on the extent that graded performance tradeoff was possible with graded priority changes. Detailed analysis of the performance and time-sharing strategies called into question the conclusions based exclusively on the PRP paradigm.