The role of the central nervous system in sudden cardiac death: Heartbeat dynamics in conscious pigs during coronary occlusion,psychologic stress and intracerebral propranolol

Electrocardiograms were recorded in conscious pigs during psychological stress (touching), left anterior descending coronary artery occlusion, intracerebral levo-propranolol (0.05 mg/kg), and their respective controls. The R-R intervals were evaluated with both a deterministic measure (point correlation dimension) and a stochastic one (mean). Only the deterministic measure was sensitive to between-subject responses (P<.01), whereas both measures were sensitive to within-subject changes. The results are explained by a deterministic model of heartbeat generation. Supported by the National Institute of Health Grant NS 27745.     

Frequency ratios and the discrimination of pure tone sequences

We examined the effect of frequency ratios on the discrimination of patterns of alternating pure tones (ABABA). Listeners heard a repeating pattern presented in transposition (same frequency ratios between successive tones, different absolute frequencies) and were required to indicate when the pattern changed (different frequency ratios and absolute frequencies). Changes from patterns with simple frequency ratios to those with more complex ratios were more readily detected than were changes from complex ratios to simpler ratios.     

Measuring and predicting the effects of alcohol consumption on contrast sensitivity for stationary and moving gratings

Contrast sensitivity was measured for 12 healthy young males while sober, after ingestion of an alcohol placebo, and after ingestion of alcohol (95% grain alcohol; mean estimated blood alcohol level = .088%). Observations were made for both stationary gratings and gratings that traveled through a circular path and required pursuit eye movements. The significant alcohol-related reduction in contrast sensitivity was 2.6 times greater for moving (.29-log-unit reduction) than for stationary gratings (.11-log-unit reduction). The loss in contrast sensitivity for the moving gratings of high spatial frequency (12 cpd) was particularly severe (.37 log unit). Estimated blood alcohol level was correlated with the loss in contrast sensitivity for moving gratings (r = .61), but not with the loss for stationary gratings. Estimated blood alcohol level was strongly correlated with the difference between the loss in contrast sensitivity to moving and stationary gratings (r = .75). These results are consistent with reports that alcohol consumption degrades the ability to make pursuit eye movements. Subjects’ perceived intoxication level was not a reliable predictor of any index of visual performance.     

Visual slow brain potentials in children with attention deficit disorder

Using a two-stimulus reaction time paradigm, with two separate reward conditions (contingent and noncontingent), we compared slow wave brain potentials (ERPs) in 144 children with attention deficit disorder (ADD) and 30 normal control children. This article reviews the findings during the 900 msec visual warning stimulus. As we had expected, based on ERP work of Forth and Hare (1989) and Raine, Venables and Williams (1990), and on previous work from our own laboratory, the group differences were found in the negative slow wave portions of the ERP complex during the contingent reward condition but not during the noncontingent condition. Aggressive hyperactive subjects with attention deficit disorder (ADDHA) were discriminated from nonaggressive subjects (including control subjects) during the contingent reward condition in the following ways: (1) greater fronto-central negativity (640–900 msec slow wave) and (2) greater right parietal than left parietal negativity (430–750 msec slow wave). All ADD subgroups, when compared to control (CONTR) subjects, showed greater slow wave negativity (700–900 msec) at the midline occipital electrode site during the contingent reward condition. This could be explained in part as an IQ effect on ERPs reflecting the IQ difference between the ADD subgroups and the controls. These slow wave findings seem to relate to attentional problems of these children. They are discussed in terms of a psychobiological model of inhibition/disinhibition and appetitive activation.     

Contemporary views of man in psychology

Summary Contemporary views of man in psychology are in flux. The American tradition of experimental materialism is being modified by serious attention to personality theory. The existential movement in Europe is beginning to have a serious influence on both theory and therapy. The development of psychosomatic medicine is part of a vital reconsideration of the problems of mind-body. And within the psychotherapeutic disciplines, serious attention is being given to the role of patient-therapist values and the therapeutic concept of man. The relevance of spiritual concepts is being given serious consideration, and potential modifications of theology and psychology are being entertained by both disciplines. Hopefully, out of this interchange will develop more adequate concepts of man and God.Presented at Eastern Mennonite College and Seminary, January, 15, 1965, as one of the 1964–65 lecture series on Contemporary Views of Man.