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251.
Fragile X speech phonology in Finnish 总被引:1,自引:0,他引:1
Fragile X syndrome is a recently discovered relatively common syndrome linked with an anomaly of the X chromosome and causing handicaps of cognitive development especially in males. In the present phonological analysis we will discuss the sound patterns of two Finnish fragile X speakers, a five (borderline intelligence)- and an eight (mildly mentally retarded)-year-old boy. The fragile X syndrome is not necessarily linked with any anomalies of speech organs. The subjects could produce all Finnish speech sounds in isolated test words. However, in the present samples of connected speech they exhibited general dysphonology. What is noteworthy is that their phonological error patterns resembled each other to a great extent. Among the common features were the tendencies to substitute and omit phonemes. As for vowels, our results showed about one-half of the errors to be omissions. Labiality and quantity oppositions were quite resistant to substitution. Most substitution errors of place of consonants occurred in dentals. As for the feature of manner, /r/ and /s/ were the phonemes most prone for substitution. A tendency toward spirantization or /h/ sation was common for both patients. The number of additions was clearly lower than has been reported for English-speaking developmentally dyspraxic children and also for Finnish Broca's aphasics. The speech problems of our patients seemed to indicate higher level motor encoding problems of linguistic information rather than peripheral articulatory deficits. 相似文献
252.
Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats 总被引:1,自引:0,他引:1
E D Levin 《Behavioral and neural biology》1988,50(2):240-245
Recent evidence indicates that acetylcholine and dopamine play complementary roles in cognitive as well as motor functions. In our previous study, the dopamine receptor blocker, haloperidol, was found to attenuate the radial-arm maze choice accuracy deficit caused by the muscarinic acetylcholine receptor blocker, scopolamine. Haloperidol has activity in blocking both D1 and D2 dopamine receptor subtypes. The current study was conducted to determine whether this dopamine-acetylcholine interaction specifically involved D1 or D2 dopamine receptors. The D1 antagonist, SCH 23390, and the D2 antagonist, raclopride, were administered with a dose of scopolamine which caused choice accuracy deficits in the radial-arm maze. The scopolamine-induced deficit was reversed by SCH 23390, the D1 antagonist, indicating that D1 blockade alone is sufficient to reverse the amnestic effects of muscarinic blockade. There was no indication in this study that the D2 blocker, raclopride, had a similar effect. However, this does not mean that such an effect may not be present at other doses of raclopride or with other D2 antagonists. The present finding that D1 blockade counteracts scopolamine-induced cognitive dysfunction not only furthers the understanding of dopamine-acetylcholine relationships in cognitive function, it also suggests a promising direction for the development of treatments for cognitive dysfunction due to cholinergic loss. 相似文献
253.
Fighting pairs of isolated DBA/2 mice showed a significant increase in tail-flick response latencies independent of whether opponents were losing or winning the combat. The effect lasted less than 10 min in both animals. Elevated pain thresholds were also found in isolates that attacked a nonaggressive conspecific, and were prevented by naltrexone (0.2 mg/kg), while a larger dose (1.0 mg/kg) inhibited the attack behavior. A small increase in pain threshold was observed after exposure of isolates to the test box alone, while isolation per se had no effect on baseline tail-flick latencies. The data demonstrate that endogenous pain suppressing systems are activated during attack and suggest that this opioid-mediated antinociception is a correlate of the isolation syndrome, reflecting enhanced arousal of the attacking animal. 相似文献
254.
Summary Network models of semantic memory assume implicitly or explicitly that the degree of activation of a node is a monotonic function of the total amount of excitation reaching that node from all sources. For example, the activation level of the node representing apple should be greater if it is receiving excitation due to the activation of the nodes for fruit and pear than if only one of these neighboring nodes is activated. This notion was tested by presenting semantic primes 80 ms or 320 ms before a letter string (e.g., apple or ipple) requiring a lexical decision. The prime stimuli consisted of a pair of simultaneous items that were identical in the single prime condition (e.g., fruit/fruit or pear/pear) or different in the double prime condition (e.g., fruit/pear or pear/fruit), and were either related (target = apple) or unrelated (target = copper) to the target, or neutral. As predicted by the summation of semantic activation assumption of network models there was a larger priming effect (in the 320 ms SOA condition) following the simultaneous activation of two related nodes than following the activation of only one node.This research was supported by grants to the first author from the Natural Sciences and Engineering Research Council of Canada. 相似文献
255.
Summary The interactive-activation model postulates (a) that activation at the letter level leads automatically to activation at the word level, (b) that the word-superiority effect reflects reactivation of letters by the word they spell, and (c) that subjects identify words on the basis of information obtained from separate letter-position channels. In the first two experiments, we showed words in upper, lower, or mixed case: the word-superiority effect was reduced when words were presented in mixed-case letters, presumably because extra-letter information is lost with mixed-case presentation; i.e., postulate (c) is wrong. The third experiment showed that when the letters of a word are rotated 180° subjects can identify the letters without producing a word-superiority effect; i.e., one of postulates (a) and (b) is wrong. In Experiments 4 and 5, we trained subjects to name words presented in inverted letters; training was more effective when subjects could exploit bigram information in addition to letter-channel information; i.e., reading inverted text is based on extra-letter-feature information, not on a general skill in rotating letters. Taken together, our data deny three of the interactive-activation model's major postulates. We offer some suggestions for future versions of the model.
Electronic mail: Userid: MEWHORTD; Nodeid: QUCDN; Domain: BITNET 相似文献
256.
257.
James B. Wade Ph.D. Robert P. Hart Ph.D. Donald F. Kirby M.D. Peter R. Mills M.D. 《Group》1988,12(3):172-178
This study evaluated the efficacy of the Garren-Edwards Behavior Modification Program, which uses the Garren-Edwards Gastric Bubble as an adjunct to treatment. Group therapy sessions were conducted with 23 morbidly obese subjects for 6 months on a biweekly basis. Each therapy session used a five-stage problem-solving sequence designed to facilitate adaptive behavioral alternatives. In evaluating weight change, a multivariate analysis of variance was conducted along with two preplanned orthogonal comparisons. Patients lost significant amounts of weight between initial to 3-month (p<.0001) and 3- to 6-month intervals (p<0001). A similar treatment effect was noted in an additional sample of 24 morbidly obese subjects following 3 months of treatment (p<0005). The findings support the value of longer goal-oriented programs in promoting continued weight loss. Implications for treatment process and therapist interventions prompted by this new format are discussed. 相似文献
258.
Bernard E. Whitley Jr. 《Sex roles》1988,19(9-10):619-638
This study examined the relations of gender and three aspects of gender roles — self concept, behavior, and sexual attitudes — to three aspects of sexual behavior — sexual experience, reasons for intercourse, and contraceptive use. Gender was strongly related to all three aspects of sexual behavior. For both men and women, sex role behaviors were related to sexual experience and to reasons for intercourse, but not to contraceptive use, and sex role self-concept was unrelated to any of the aspects of sexual behavior. The results indicate that sexual behavior is influenced both by societal gender role norms and by individual differences in the acceptance of those norms. 相似文献
259.
J L Gariépy K E Hood R B Cairns 《Journal of comparative psychology (Washington, D.C. : 1983)》1988,102(4):392-399
This research was designed to investigate development and behavioral mediation in lines of ICR mice that have been selectively bred for aggressive behavior. General behavioral reactivity and behavioral immobility have been implicated as potential mediators by prior analyses of preattack interactions. To evaluate the separate roles of these dispositions, the emergence of attacks in genetically selected lines was tracked for 11 years by three levels of analysis: over successive generations, over development, and over dyadic interactions. Convergent outcomes were observed in all three levels with respect to two findings: (a) Robust line differences were obtained in attack behaviors, and (b) strong associations were found between line differences in attacks and line differences in behavioral immobility. Conversely, all three levels of analysis indicated a weak and inconsistent association between line differences in attacks and measures of social and nonsocial reactivity. 相似文献
260.
U W Huck R D Lisk E J Parente 《Journal of comparative psychology (Washington, D.C. : 1983)》1988,102(4):388-391
After 12-15 ejaculatory series, each consisting of several short intromissions (2- to 3-s vaginal penetration) and an ejaculation, male golden hamsters adopt an altered copulatory pattern consisting of long intromissions (5- to 25-s penetration with intravaginal thrusting). Receptivity declines and the tendency for the female to attack the male increases at about the time of this shift in copulatory pattern. Because the mean interintromission interval (III) between short intromissions is about 8 s compared to 100 s between long intromissions, it is possible that females detect this difference and adjust their mating accordingly. When the III between short intromissions from a rested male was experimentally increased to 100 s by use of a halter and lead device, the duration of lordosis was significantly less than that displayed by females paired with control males (8-s III) and virtually the same as that displayed by females paired with males that produced only long intromissions. This suggests that the female uses the temporal patterning of intravaginal stimulation as one criterion for terminating mating with a particular male. 相似文献