Toxic "atrophie cerebelleuse". (problems associated with permanent cerebellar damage due to chronic diphenylhydantion intoxication)

The authors report two cases with roentgenomophologically established cerebellar atrophy caused by chronic diphenylhydantoin overdosing. Exact neuropsychiatric testing of epileptics treated with diphenylhydantoin for a long period of time is demanded, and it is recommended that in the case of long-time therapy a maximum daily dose of 0.3 g of diphenylhydantoin be not exceeded.     

Relative costs and statistical power in the extreme groups approach

The relationship between variables in applied and experimental research is often investigated by the use of extreme (i.e., upper and lower) groups. Recent analytical work has provided an extreme groups procedure that is more powerful than the standard correlational approach for all values of the correlation and extreme group size. The present article provides procedures to optimize power by determining the relative number of subjects to use in each of two stages of data collection given a fixed testing budget.The opinions or assertions contained herein are those of the writers and are not to be construed as official or reflecting the views of the Navy Department.Edward F. Alf, Jr. is also affiliated with the Department of Psychology, San Diego State University.     

An alternative perspective on sex differences in organizational settings: The process of legitimation

This article takes a sociological approach to a problem that has usually been considered as a psychological phenomenon. It addresses the problem of male—female interactions in work situations utilizing the organizational concepts of division of labor and legitimacy. Traditional explanations evoking sex-role socialization are reviewed and rejected for purposes of experimentation and intervention. An alternative argument, focusing on the structural arrangements of organizational settings, is presented as an explanation for behavioral effects previously attributed to inherent sex differences. The results of a pilot study are briefly described, and directions for further experimentation and possible intervention strategies are suggested.The bibliographic search and initial conceptualization of this research was supported by a grant from the Ford Foundation under the auspices of the Center for Research on Women at Stanford University. We are grateful to Miriam Rosen for much of the bibliographic work. The pilot study was supported in part by funds from the Guggenheim Foundation and by a grant from the Spencer Foundation. We also wish to thank Richard Torres and Christie Timberlake for their invaluable assistance on this project.     

Conditioned fear and startle magnitude: effects of different footshock or backshock intensities used in training

In Experiment 1 four groups of rats received 30 light-shock pairings using footshock intensities of either .2, .4, .8, or 1.6 mA. One day later all rats were tested for startle by presenting tones in the presence or absence of the light CS. Potentiated startle (the difference between startle on light-tone vs tone-alone trials) was nonmonotonically related to the shock intensity used in training, with the greatest potentiation at intermediate shock levels. Experiment 3 demonstrated a similar relationship when backshocks instead of footshocks were used. In Experiment 2 rats were trained with either a moderate or high shock and then given an extended extinction-test session 1 day later. The moderate-shock group showed a gradual decline in potentiated startle over extinction. The high-shock group showed a nonmonotonic extinction curve where potentiation progressively increased toward the middle of extinction and dissipated thereafter. The results suggest that acoustic startle bears an inverted U-shaped relationship to fear and are discussed in relation to other studies concerned with this issue.     

PLE: A high-level multiprogramming language for psychology

This paper describes a software system called PLE that is designed to turn a Data General Corporation computer system into a sophisticated infinite-channel tachistoscope. We describe hardware and software characteristics of the PLE system and evaluate its performance in comparison to a typical tachistoscope. Additionally, we describe two example experiments that have been implemented in the PLE system.     

Microprocessors in the laboratory: Dedicated computation and time-shared peripherals with REMOTE-11

This article describes a new solution to the dilemma faced by investigators who need dedicated computers but cannot afford the cost of expensive peripherals. An available software-hardware combination is described that permits users to timeshare expensive peripherals but to have a dedicated microprocessor at their disposal.