Interaction of genetics and separation in canine hyperkinesis and in differential responses to amphetamine

A model of childhood hyperkinesis, using the Telomian-beagle hybrid dog, is described, demonstrating the interactions of genetics and separation in the development of this syndrome and in the favorable responses of some of these dogs to amphetamine. This work represents the collaboration of three laboratories, utilizing chiefly methods of inhibitory training. Inducing separation distress enhanced the resistance to inhibitory training and the favorable responses to amphetamine.     

Intracranial cannulation of small animals

Special difficulties are encountered when attempting to provide intracranial cannulation of small animals that have floating or fragile skull bones. The technique described was developed for mice but seems applicable to other species. The cannula system is inexpensive and easy to use. A wound clip anchor seems superior to either skull screws or bonded acrylic, producing less damage to the brain and no necrosis of bone or tissue on the wound margin. Patency data up to 25 days is presented, and the system is as efficacious as other techniques.     

Hand differences in the rate and variability of rapid tapping

Hand differences in the rate and variability of rapid tapping were evaluated for the intertap interval and its constituents-the key depression and key release phases of each tap. To accentuate potential hand differences, only subjects with a clear manual superiority in one hand were included. Relative manual proficiency on Fitts' reciprocal tapping task was used to exclude individuals with less-defined hand superiority or dominance, and to categorize subjects as having a dominant left (n=13) or right (n=11) hand. Analysis of variance indicated the dominant hand to have a shorter average intertap interval and thus a faster tapping rate. This hand difference in rate was found to be significant for the key-depression phase, but not the key-release.phase, of the tap. In each handedness group the dominant hand exhibited less variability in the intertap interval and both constituents. Potential associations of these findings with hemispheric asymmetries in sequential ability are discussed.     

The development of sexual identity

The development of sexual identity was studied in 686 individuals, using a fantasy measure of sexual identity that does not depend on learned sex-role stereotypes. The results showed a marked differentiation between the sexes at pre-adolescence, a loss of differentiation during the freshman year of college that most closely resembled the lack of differentiation in sexual identity of preschool children, and a reemergence of a clear sexual identity during the last years of college. Possible biological, social context, and psychodynamic-maturational explanations for this pattern of development are discussed.     

Assessment of personality and demographic aspects of cohabitation and marital success

The outcomes of 68 marriages of four-year duration were compared on the basis of whether the partners had or had not cohabited premaritally. Background characteristics and personality data were assessed on those couples when there were newly married, and they were followed-up four years later to determine their current marital status, level of satisfaction, difficulty with various problem areas and the number of children born to them. No reliable differences on marital satisfaction or divorce rates between premarital cohabitors and noncohabitors were found. Cohabitors who divorced did so while reporting less marital distress than noncohabitors who divorced. Premarital cohabitors had significantly fewer children than noncohabitors. Degree of difficulty experienced on various problem areas differed between the groups. Certain personality and background variables predicted marital success differently for the two groups. Using the same selected set of six predictor variables, multiple regression equations were generated for cohabitors and noncohabitors. The cohabitors equation (R2 = .56) predicted marital success significantly more effectively than the noncohabitors equation (R2 = .28), When comparing the tri-weight vectors for these two equations, none of the predictor variables had the same influence in both groups. Theoretical implications of the findings were discussed.     

Delayed alternation in the rat: Effect of contextual stimuli on proactive interference

The effect of contextual stimuli on proactive interference in the rat was investigated in three experiments. The task was a modified delayed alternation procedure in which the rat was initially forced to one side of a T maze (the interfering forcing) followed by a forcing to the opposite side (the target forcing). A free choice run followed the target forcing in which a turn in either direction could be made. In order to obtain reinforcement on the free choice run, the rat was required to turn in the direction opposite that of the target forcing (i.e., in the same direction as the interfering forcing). Manipulation of the context prevailing during the interfering forcing, target forcing, and free choice runs revealed that free choice accuracy was (a) greater when the interfering and target forcings were conducted in different contexts than when they were conducted in the same context and (b) influenced only slightly, if at all, by whether the free choice context coincided with that prevailing during the interfering forcing or with that prevailing during the target forcing.     

Alternative fixed-ratio fixed-interval schedules of reinforcement

Five rats were trained under alternative fixed-ratio fixed-interval schedules, in which food reinforcement was provided for the completion of either a fixed-ratio or a fixed-interval requirement, whichever was met first. Overall response rate and running rate (the rate of responding after the postreinforcement pause) decreased for all subjects as the fixed-ratio value increased. As the proportion of reinforcements obtained from the fixed-ratio component increased and the alternative schedule approached a simple fixed ratio, overall response rate and running rate both increased; conversely, as the proportion of reinforcements obtained from the fixed-interval component increased and the alternative schedule approached a simple fixed interval, response rates decreased. Postreinforcement pause length increased linearly as the average time between reinforcements increased, regardless of the schedule parameters. A break-run pattern of responding was predominant at low- and medium-valued fixed ratios. All subjects displayed at least occasional positively accelerated responding within interreinforcement intervals at higher fixed-ratio values.     

Test for effects of visual and position cues on T-maze learning in toads

This research was concerned with the effects of different classes of cues on the ability of toads (Bufo marinus) to learn an escape task, discrimination learning, in a T-maze. The cues were either a black or white brightness cue, a right or left position cue, or combinations of brightness and position cues. The toads were given a .6-A shock until they made the correct response. Results suggested that toads are capable of learning a discrimination task based on either a position or brightness cue. However, the rate of learning was influenced by strong aversion to the white arm when escaping from an aversive stimulus. No particular preference for either brightness or position cues was found independent of this aversion.     

Assessment of the relative importance of S+ and S− in rats using differential training on intercurrent discriminations

The present studies assessed the degree of stimulus control exerted by S+ and S? without confoundings of stimulus novelty and stimulus ambiguity. In Experiment 1, rats were trained on two intercurrent simultaneous discrimination problems with nine times more training given on one than the other. Then the animals were given transfer tests with re-paired stimuli. The results showed that S? exerts greater stimulus control than S+ in a two-choice simultaneous discrimination. Experiment 2 provided a test of the possibility that the relative degree of control by S? varies with different amounts of training. Three groups were trained on two intercurrent simultaneous discrimination problems; each group was given 7, 11, or 15 times more training on one problem than the other. Then transfer tests were given with re-paired stimuli. Again the results showed that S? exerts greater stimulus control than S+ in a two-choice simultaneous discrimination.