Obstructive Sleep Apnea Syndrome in Prader-Willi Syndrome: An Unrecognized and Untreated Cause of Cognitive and Behavioral Deficits?

Prader-Willi Syndrome (PWS) is a rare genetic disorder characterized by a range of physical, psychological, and physiological abnormalities. It is also distinguished by the high prevalence of obstructive sleep apnea syndrome (OSAS), i.e., repetitive upper airway collapse during sleep resulting in hypoxia and sleep fragmentation. In non-PWS populations, OSAS is associated with a range of neurocognitive and psychosocial deficits. Importantly, these deficits are at least partly reversible following treatment. Given the findings in non-PWS populations, it is possible that OSAS may contribute to neurocognitive and psychosocial deficits in PWS. The present review examines this possibility. While acknowledging a primary contribution from the primary genetic abnormality to central neural dysfunction in PWS, we conclude that OSAS may be an important secondary contributing factor to reduced neurocognitive and psychosocial performance. Treatment of OSAS may have potential benefits in improving neurocognitive performance and behavior in PWS, but this awaits confirmatory investigation.     

Sociotropy-autonomy and situation-specific anxiety

Sociotropy and autonomy are conceptualized as two personality dimensions that relate to individuals' vulnerability to anxiety and depression. Sociotropy is characterized as an excessive investment in interpersonal relationships, and autonomy is characterized as an excessive concern with independence as well as a lack of concern for others. The present study investigated the relationships between sociotropy-autonomy and trait anxiety associated with four types of situations, i.e., Social Evaluation, Physical Danger, Ambiguous Situation, and Daily Routine. 255 undergraduate students completed the Sociotropy-Autonomy Scale, the Endler Multidimensional Anxiety Scale, and the Beck Depression Inventory. Analyses indicated that scores on Sociotropy were positively correlated with rated trait anxiety in situations of Social Evaluation, Physical Danger, and Ambiguous Situations, whereas scores on Autonomy were positively correlated with rated trait anxiety in Daily Routines. These findings are discussed in the context of the diathesis-stress model of anxiety and depression.     

Complexity factors in visuo-spatial working memory

Three experiments are presented that use a technique of selective interference--irrelevant pictures--to develop our understanding of visuo-spatial working memory. Visual noise fields are used as the irrelevant pictures. Using two related measures of simple visual complexity, the experiments demonstrate that the greater the complexity the greater the degree of interference, even within a paradigm where subjects are instructed to look at but otherwise ignore the irrelevant pictures. Both the number of dots and the density of the dots comprising the visual noise fields affect the degree of interference in a concurrent memory task. In addition, increasing the size of the field increases the amount of interference. It is argued that the results give insight into the properties of visual working memory and contribute to its theoretical development. For example, it is argued that the store is directly accessible by externally presented interference and that particular aspects of the noise displays cause interference with visual memory.     

The natural appearance of unnatural incline speed

In three experiments, college students provided judgments about a marble's speed along a nonlinear incline. Each experiment revealed widespread support for the slope-speed belief, a mistaken belief holding that an object's speed at any point depends on the slope at that point. In truth, an object's incline speed varies with its elevation. In Experiment 1, participants relied solely on a diagram. In Experiments 2 and 3, participants observed computer animations depicting the descent of a marble at speeds conforming to either the slope-speed belief or Newtonian theory, and they rated the slope-speed version as more "natural" than the correct version. The task in Experiment 1 gauged participants' consciously available knowledge, but the perceptual realism of the slope-speed animations suggests that the slope-speed belief is also held outside awareness. By contrast, virtually all previously identified false beliefs about motion appear unnatural once animated.     

Concurrent task effects on memory retrieval

Previous studies combining continuous free recall with a concurrent task have generally shown that concurrent tasks impose fairly negligible effects on memory retrieval. By contrast, dual-task studies employing either cued recall or semantic retrieval reveal gross memory impairment and suggest that retrieval is delayed by the centrally demanding phase of the concurrent tasks (i.e., response selection). To explore this conflict, subjects performed continuous free recall while carrying out a serial-choice#x2014; response time (RT) task, as in the previous free recall studies. Unlike these previous studies, however, the choice#x2014;RT task utilized arbitrary stimulus#x2014;response mappings in order to increase the proportion of time devoted to the centrally demanding response selection phase. Recall total was reduced significantly, and recall latency was slowed substantially.     

Adjustment to parental divorce: An examination of the differences between counselled and non-counselled children

To evaluate an innovative counselling service, two groups of children of divorce were studied: one that was receiving counselling and a non-counselled group. The differences between the two groups were examined in relation to such areas as self-esteem and their relationships with their parents prior and subsequent to separation.     

Long-term positive and negative identity priming: Evidence for episodic retrieval

An episodic retrieval account of negative priming (Neill, 1997; Neill & Valdes, 1992) was evaluated in three experiments. Duringpractice, regular word pairs were presented to subjects differing numbers of times. The subjects named specific target words while they ignored specific distractor words. Following a 5-min retention interval, memory for practice was revealed:Test responses for target words exhibited positive priming that increased with increases in the number of times that the words had been attended. Test responses for distractor words exhibited either positive priming (Experiment 1) or negative priming (Experiments 2–3) that also increased with increases in the number of times that the words had been ignored. The type of priming that abstractors exhibited was determined by several contextual similarities between the practice environment, in which distractors were ignored initially, and the test environments, in which they were processed subsequently. Negative priming that spanned a 5-min interval, increased with increases in the number of times that a distractor was ignored, and was sensitive to contextual changes indicated that the direction of the effect was temporally backward because the test probe cued memory for earlier processing of the priming stimulus when the distractor had been ignored.     

When two memories can and cannot be retrieved concurrently

We examined whether two memories can be retrieved concurrently from long-term memory. In Experiment 1, the subjects recalled words, either from two categories—alternating between the two—or from just one category. In Experiment 2, the subjects recalled two words belonging to either the same category or different categories, and the category prompts for these two responses appeared either simultaneously or successively. The results of both studies are consistent with the view that two items from different categories must be retrieved serially, whereas two items from the same category can be retrieved in parallel.     

The “EA brief”: A single session of parent feedback and coaching to improve emotional attachment and emotional availability (EA)

The goal of this study was to determine the extent to which a brief parenting intervention provided the context for helping families to support positive mother–child interactions as well as more optimal mother and child outcomes. Participants in this study were middle income mothers and their children were between 0–3 years of age (N = 25 dyads). Participants were filmed via Skype during a 20-minute mother–child free play and completed questionnaires (Time 1) before attending the brief intervention (involving: a single session of one-on-one parent feedback and coaching, and information via group meeting, texts, and reading) followed by a repeat of the 20-minute Skype interaction and the completion of the same questionnaires (Time 2). Paired samples t-tests were performed, revealing that mothers reported improvements in their personal well-being (using the Flourishing Scale), reports about the mother-child relationship (using the Emotional Availability Self Report), and observed interactions, particularly the child's side of the relationship (using the Emotional Availability System), from pretest to posttest. Results are discussed in terms of a single session of parent feedback and coaching (in conjunction with an informational group session and texts) potentially having a role in “planting a seed” for observed and self-reported parenting enhancement and child development.