Ethical Issues Raised by Epigenetic Testing for Alcohol,Tobacco, and Cannabis

Epigenetic testing is one of the most significant new technologies to provide insight into the behavioral and environmental factors that influence the development and reconfiguration of the human genetic code. This technology allows us to identify structural changes in the genome that occur due to exposure to a wide variety of substances including alcohol, tobacco, and cannabis. The information gained can be used to promote health but it also raises a variety of ethical, legal, and social issues. As society progresses in understanding the epigenetic mechanisms of substance use and addiction, there is an opportunity to use these use this knowledge to enable medical, behavioral, and environmental interventions to alleviate the burden of addiction. This article describes the ethical issues associated with use of epigenetic testing for alcohol, tobacco, and cannabis and the implications of this technology. A further review of the scientific basis for the relevance of epigenetics is found in the accompanying article by Philibert and Erwin in this issue. Copyright © 2015 John Wiley & Sons, Ltd.     

Visual attention in infants with perinatal brain damage: Evidence of the importance of anterior lesions

Shifts of visual attention can be studied in adults and infants by cueing responses to a particular spatial location. Earlier studies have shown that by seven months of age normal infants show a similar pattern of facilitation and inhibition to a cued spatial location as adults. In this study we report data from infants with perinatal lesions that include or exclude the left anterior quadrant. Results indicate that infants with left anterior lesions do not show facilitation to a cued spatial location in this task. In contrast, infants with posterior lesions showed the same pattern of performance as healthy subjects. While these findings differ from those obtained with adults, they are consistent with previous studies of children with perinatal lesions, and with findings from ERP studies with normal infants.     

Stimulus factors and listening strategies in auditory memory: A theoretical analysis

A theory for the temporal course of perceptual coding during auditory short-term memory tasks is described. A low-level “sensor” and a high-level “identifier” process item and order information from stimulus word-strings. Both word durations and interword pauses are needed for this processing, and if adequate processing time is unavailable, perceptual delays will lead to degraded recall performance. Stimulus parameters and subject strategies interact to determine the quality and the order in which stimulus items are coded. These hypotheses are supported both by experiments using grammatical sentences and those using lists of unrelated words.     

Perception and immediate recall of normal and “compressed” auditory sequences

For a fixed presentation rate, the ratio of speech-to-pause time was varied in three experiments. Ss recalled seven-digit sequences or monitored for item or order information in addition to recall. Removing 33% of the speech and substituting pause time improved recall accuracy and monitoring reaction times. The data suggest that loss of order information in recall may result from cumulative perceptual delays when adequate pause time is unavailable.