异种器官移植及其伦理问题

目前,开展的异种移植研究主要以猪为供体源,面临的主要障碍是宿主抗移植物的免疫排斥反应(超急性排斥、急性排斥和慢性排斥)和猪内源性反转录病毒感染,并已取得一定进展.但异种移植引发的伦理问题也不容忽视,主要有跨物种感染、卫生资源分配、动物的权利和人格同一性等问题.     

陕西地区初中生心理健康素质特点调查

对陕西地区1299名城乡初中生进行分层整体取样调查,结果表明：（1）初中生心理健康素质在人际素质、动力系统、自我和归因风格方面城乡差异显著;（2）在适应、人际素质、动力系统、自我和归因风格方面初二得分高于初一和初三,年级差异显著;（3）在动力系统和归因风格方面女生得分显著高于男生,男生认知风格得分显著高于女生。     

基于多元回归的调节效应分析

在心理学和其他社科研究领域,大量实证研究建立调节模型,以分析自变量对因变量关系的影响机制,但在基于多元回归的调节效应分析实践中仍存在不足。我们回顾了均值中心化在基于多元回归的调节效应分析中的作用,均值中心化不影响乘积项(即调节效应)的检验,仅对一阶项(即主效应)的检验有影响。讨论了简单斜率的检验方法,建议在调节变量为连续变量时,使用Johnson-Neyman法进行简单斜率检验;在调节变量为类别变量或研究者对某个调节变量值感兴趣时,使用选点法。并用一个实际例子演示如何进行调节效应分析。随后展望了调节效应检验的拓展方向。     

增加卫生改革的伦理含金量——兼论卫生改革中的效率与公平

卫生改革需要有包括卫生改革伦理学理念在内的全方位改革理念的联手支撑。伦理含金量缺失或者不足,卫生改革实践就难以取得圆满成功。因此,目前展开的新一轮卫生改革,必须以“效率与公平合理兼顾”为核心准则,在完善政策、规划目标、组织实施等全过程中切实保证卫生改革伦理学理念准确到位和正常运作。     

The relationship among resilience,rumination and posttraumatic growth in hemodialysis patients in North China

Research has indicated that clinical serious disease may lead to posttraumatic growth (PTG). However, little is known about PTG among hemodialysis (HD) patients. The study examined the relationship among resilience, rumination and PTG among Chinese HD patients. 196 HD patients were recruited from a tertiary hospital in a Northern city of China between 1 June 2015 and 30 May 2016. Patients were surveyed using the Posttraumatic Growth Inventory-Chinese version, Connor-Davidson Resilience Scale, and Chinese Event Related Rumination Inventory. Correlation analyses showed that resilience was most highly positively correlated with PTG (r = .70, p < .001), deliberate rumination moderately correlated to PTG (r = .50, p < .001), and intrusive rumination was lower negatively related to PTG (r = –.26, p < .001). Regression analyses showed that age, gender, duration of dialysis, resilience and deliberate rumination had significant associations with PTG (β = ?.31, p ＜ .0001; β = –.14, p = .002; β = .10, p = .032; β = .44, p < .001; β = .20, p < .001). They together explained 65% of the total variance in PTG (F [8,195] = 46.74, p < .001). However, intrusive rumination was not associated with PTG (p > .05). The results suggested that resilience and deliberate rumination may be instrumental for PTG improvement.     

Children show limited movement repertoire when learning a novel motor skill

Examining age differences in motor learning using real‐world tasks is often problematic due to task novelty and biomechanical confounds. Here, we investigated how children and adults acquire a novel motor skill in a virtual environment. Participants of three different age groups (9‐year‐olds, 12‐year‐olds, and adults) learned to use their upper body movements to control a cursor on a computer screen. Results showed that 9‐year‐old and 12‐year‐old children showed poorer ability to control the cursor at the end of practice. Critically, when we investigated the movement coordination, we found that the lower task performance of children was associated with limited exploration of their movement repertoire. These results reveal the critical role of motor exploration in understanding developmental differences in motor learning.     

Exposure to the Chinese famine in early life and depression in adulthood

We aimed to investigate whether exposure to the Chinese famine (1959–1961) in early life was associated with depression in adulthood. We included 17,505 participants from the China health and retirement longitudinal study (CHARLS). Participants were classified into indirect and direct exposure groups. And the directly exposure groups including prenatal, childhood, adolescence/adult exposure groups. Depression was diagnosed by Center for Epidemiological Studies Depression Scale-10 (CES-D) score. Multivariate logistic regression model was used to calculate the odd ratios (ORs) and 95% confidence intervals (CIs) of depression. In women, prenatal, childhood, adolescence/adult exposure groups had higher depression risk than indirect exposure group (OR = 1.46, 1.40, and 1.67, respectively). However, there was no significant association between famine exposure and depression among men. Exposure to famine during prenatal (OR: 1.48; 95% CI: 1.07–2.06), childhood (OR: 1.47; 95% CI: 1.13–1.91), and adolescence/adult (OR: 1.63; 95% CI: 1.24–2.15) period were associated with depression among subjects living in rural, but not those living in urban. Exposure to the Chinese famine in early life had sex and area-specific associations with depression.     

Normative values for a tablet computer-based application to assess chromatic contrast sensitivity

Tablet computer displays are amenable for the development of vision tests in a portable form. Assessing color vision using an easily accessible and portable test may help in the self-monitoring of vision-related changes in ocular/systemic conditions and assist in the early detection of disease processes. Tablet computer-based games were developed with different levels of gamification as a more portable option to assess chromatic contrast sensitivity. Game 1 was designed as a clinical version with no gaming elements. Game 2 was a gamified version of game 1 (added fun elements: feedback, scores, and sounds) and game 3 was a complete game with vision task nested within. The current study aimed to determine the normative values and evaluate repeatability of the tablet computer-based games in comparison with an established test, the Cambridge Colour Test (CCT) Trivector test. Normally sighted individuals [N = 100, median (range) age 19.0 years (18–56 years)] had their chromatic contrast sensitivity evaluated binocularly using the three games and the CCT. Games 1 and 2 and the CCT showed similar absolute thresholds and tolerance intervals, and game 3 had significantly lower values than games 1, 2, and the CCT, due to visual task differences. With the exception of game 3 for blue-yellow, the CCT and tablet computer-based games showed similar repeatability with comparable 95% limits of agreement. The custom-designed games are portable, rapid, and may find application in routine clinical practice, especially for testing younger populations.     

刍议人体试验伦理审查程序的正当化

医学伦理委员会在成立之初就明确了自身的使命:确保涉及人体试验研究的"科学"、"伦理"和"监管"。但在实际操作中, 很多伦理审查委员会将程序的正义简单地理解为是不是采用了标准化的审查流程, 是否通过了国外所谓权威机构的认证, 这导致伦理审查并没有遵循一个正当的程序进行, 使其在公平性、公正性等诸多方面受到质疑。因此, 为维护受试者的核心权益, 确保涉及人体试验的医学研究有序进行, 建立正当的程序并在伦理审查过程中实现程序正义有着极为重要的意义。